Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Suriyan Ponnusamy"'
Autor:
Sarah Asemota, Wendy Effah, Kirsten L. Young, Jeremiah Holt, Linnea Cripe, Suriyan Ponnusamy, Thirumagal Thiyagarajan, Dong-Jin Hwang, Yali He, Keely Mcnamara, Daniel Johnson, Yinan Wang, Brandy Grimes, Yekta Khosrosereshki, T.J. Hollingsworth, Martin D. Fleming, Frances E. Pritchard, Ashley Hendrix, Farhan Khan, Meiyun Fan, Liza Makowski, Zheng Yin, Hironobu Sasano, D. Neil Hayes, Lawrence M. Pfeffer, Duane D. Miller, Ramesh Narayanan
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113461- (2023)
Summary: Triple-negative breast cancer (TNBC) is an aggressive subtype with no targeted therapeutics. The luminal androgen receptor (LAR) subtype constitutes 15% of TNBC and is enriched for androgen receptor (AR) and AR target genes. Here, we show th
Externí odkaz:
https://doaj.org/article/ac241ea52bf347e5b56f2020cc95e398
Autor:
Sydney C. Joseph, Samson Eugin Simon, Margaret S. Bohm, Minjeong Kim, Madeline E. Pye, Boston W. Simmons, Dillon G. Graves, Stacey M. Thomas-Gooch, Ubaid A. Tanveer, Jeremiah R. Holt, Suriyan Ponnusamy, Laura M. Sipe, D. Neil Hayes, Katherine L. Cook, Ramesh Narayanan, Joseph F. Pierre, Liza Makowski
Publikováno v:
Cancers, Vol 16, Iss 7, p 1368 (2024)
Bariatric surgery is associated with improved outcomes for several cancers, including breast cancer (BC), although the mechanisms mediating this protection are unknown. We hypothesized that elevated bile acid pools detected after bariatric surgery ma
Externí odkaz:
https://doaj.org/article/ad4335c849194130bb94e4446773aa43
Autor:
Farhan Khan, Obianuju Mercy Anelo, Qandeel Sadiq, Wendy Effah, Gary Price, Daniel L. Johnson, Suriyan Ponnusamy, Brandy Grimes, Michelle L. Morrison, Jay H. Fowke, D. Neil Hayes, Ramesh Narayanan
Publikováno v:
Biomedicines, Vol 11, Iss 3, p 648 (2023)
Androgen receptor splice variants (AR-SVs) contribute to the aggressive growth of castration-resistant prostate cancer (CRPC). AR-SVs, including AR-V7, are expressed in ~30% of CRPC, but minimally in treatment-naïve primary prostate cancer (PCa). Co
Externí odkaz:
https://doaj.org/article/6bcc6af54d354d46beb55bb163520772
Autor:
Wei Wang, Mingqi Li, Suriyan Ponnusamy, Yayun Chi, Jingyan Xue, Beshoy Fahmy, Meiyun Fan, Gustavo A. Miranda-Carboni, Ramesh Narayanan, Jiong Wu, Zhao-Hui Wu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Genotoxic agents have been shown to activate the Wnt/β-catenin signaling but the underlying mechanism remains unclear. Here, the authors show that upon DNA damage, the deubiquitinase OTULIN activates Wnt/β-catenin signaling by inhibiting linear ubi
Externí odkaz:
https://doaj.org/article/b4496d310ec64236a21571f5bea2d9bf
Autor:
Suriyan Ponnusamy, Sarah Asemota, Lee S. Schwartzberg, Fouzia Guestini, Keely M. McNamara, Mariaelena Pierobon, Alba Font-Tello, Xintao Qiu, Yingtian Xie, Prakash K. Rao, Thirumagal Thiyagarajan, Brandy Grimes, Daniel L. Johnson, Martin D. Fleming, Frances E. Pritchard, Michael P. Berry, Roy Oswaks, Richard E. Fine, Myles Brown, Hironobu Sasano, Emanuel F. Petricoin, Henry W. Long, Ramesh Narayanan
Publikováno v:
iScience, Vol 21, Iss , Pp 341-358 (2019)
Summary: Sustained treatment of estrogen receptor (ER)-positive breast cancer with ER-targeting drugs results in ER mutations and refractory unresponsive cancers. Androgen receptor (AR), which is expressed in 80%–95% of ER-positive breast cancers,
Externí odkaz:
https://doaj.org/article/dff52cda825c431a910313dacdb4bf32
Autor:
Michael Ulm, Arvind V Ramesh, Keely M McNamara, Suriyan Ponnusamy, Hironobu Sasano, Ramesh Narayanan
Publikováno v:
Endocrine Connections, Vol 8, Iss 2, Pp R10-R26 (2019)
Hormonal cancers affect over 400,000 men and women and contribute collectively to over 100,000 deaths in the United States alone. Thanks to advances in the understanding of these cancers at the molecular level and to the discovery of several disease-
Externí odkaz:
https://doaj.org/article/7d0aac4c1e994aafb0e02f6435b03e06
Autor:
Michael L. Mohler, Arunima Sikdar, Suriyan Ponnusamy, Dong-Jin Hwang, Yali He, Duane D. Miller, Ramesh Narayanan
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 2124 (2021)
Traditional endocrine therapy for prostate cancer (PCa) has been directed at suppression of the androgen receptor (AR) signaling axis since Huggins et al. discovered that diethylstilbestrol (DES; an estrogen) produced chemical castration and PCa tumo
Externí odkaz:
https://doaj.org/article/e34675d13eda4419935a324e78a0a1c0
Autor:
Michael A. Ulm, Tiffany M. Redfern, Ben R. Wilson, Suriyan Ponnusamy, Sarah Asemota, Patrick W. Blackburn, Yinan Wang, Adam C. ElNaggar, Ramesh Narayanan
Publikováno v:
Journal of Personalized Medicine, Vol 10, Iss 4, p 246 (2020)
Objective: The objective of this study is to identify and validate novel therapeutic target(s) in ovarian cancer. Background: Development of targeted therapeutics in ovarian cancer has been limited by molecular heterogeneity. Although gene expression
Externí odkaz:
https://doaj.org/article/fa0d6901fac44ded8f2f505488797dc5
Supplementary Tables S1-S4 from Neutral Sphingomyelinase-3 Is a DNA Damage and Nongenotoxic Stress-Regulated Gene That Is Deregulated in Human Malignancies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b239ae76575c819f39ce831056cd87c3
https://doi.org/10.1158/1541-7786.22521711.v1
https://doi.org/10.1158/1541-7786.22521711.v1
Autor:
Ramesh Narayanan, Duane D. Miller, James T. Dalton, Tudor Moldoveanu, Wayne D. Tilley, Christopher Ledbetter, Robert W. Wake, Geetika Singh, Jayaprakash Pagadala, Charles B. Duke, Iain J. McEwan, Luke A. Selth, Yali He, Dong-Jin Hwang, Kate Watts, Thirumagal Thiyagarajan, Christopher C. Coss, Suriyan Ponnusamy
Androgen receptor (AR) mediates the growth of prostate cancer throughout its course of development, including in abnormal splice variants (AR-SV)-driven advanced stage castration-resistant disease. AR stabilization by androgens makes it distinct from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4eabed8b39f4c2e494de62021040cfc
https://doi.org/10.1158/0008-5472.c.6509612.v1
https://doi.org/10.1158/0008-5472.c.6509612.v1