Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Surinder S. Narula"'
Autor:
Selvi Pradeepan, Chet Metcalf, Brendan F. Boyce, Shuangying Liu, Manfred Weigele, Surinder S. Narula, Regine S. Bohacek, Lianping Xing, Raji Sundaramoorthi, Jeff Keats, Julie Bogus, Jennifer Saltmarsh, Yihan Wang, Scott Wardwell, Mary K. Ram, David C. Dalgarno, John Iuliucci, Susan Adams, Guru Paramanathan, Shuenn Liou, Marie Rose van Schravendijk, Anne Dilauro, Sonya Roeloffzen, T. Keenan, William C. Shakespeare, Tomi K. Sawyer
Publikováno v:
Chemical Biology & Drug Design. 71:97-105
Targeted disruption of the pp60(src) (Src) gene has implicated this tyrosine kinase in osteoclast-mediated bone resorption and as a therapeutic target for the treatment of osteoporosis and other bone-related diseases. Here, we describe structure acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dcdeae0a92758c4ad04f2c1f5760a13
https://doi.org/10.1111/j.1747-0285.2007.00615.x
https://doi.org/10.1111/j.1747-0285.2007.00615.x
Autor:
David C. Dalgarno, Surinder S. Narula, Terence P. Keenan, Tomi K. Sawyer, Regine S. Bohacek, William C. Shakespeare, Chester A. Metcalf, Raji Sundaramoorthi, Yihan Wang, Manfred Weigele
Publikováno v:
BioTechniques. 34:S2-S15
In retrospect, the emergence of protein kinase drug discovery dates to the identification of the first oncogenic protein kinase, Src, about 25 years ago. This work has led to worldwide research efforts to investigate the genomic and proteomic relatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6db91a14d17fed30378777b30369b8d2
https://doi.org/10.2144/sawyerjun03revised
https://doi.org/10.2144/sawyerjun03revised
Autor:
Regine S. Bohacek, Karina J. Macek, Manfred Weigele, Marcos Hatada, Tomi K. Sawyer, William C. Shakespeare, Chester A. Metcalf, David C. Dalgarno, Berkley A. Lynch, Surinder S. Narula, Taylor Merry, Shelia Violette, Virginia A. Jacobsen
Publikováno v:
Journal of Medicinal Chemistry. 44:660-663
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b98587a3d11d3c4fde1d366bbe4bc3c
https://doi.org/10.1021/jm0002681
https://doi.org/10.1021/jm0002681
Autor:
M. R. Van Schravendijk, Wu Yang, Surinder S. Narula, Tim Clackson, Ruth W. Yuan, David C. Dalgarno, Mary K. Ram, Carl T. Rollins, Lawrence J. Andrade, Dennis A. Holt, T. B. Phillips, Leonard W. Rozamus
Publikováno v:
Journal of Medicinal Chemistry. 43:1135-1142
Using structure-based design and protein mutagenesis we have remodeled the FKBP12 ligand binding site to include a sizable, hydrophobic specificity pocket. This mutant (F36V-FKBP) is capable of binding, with low or subnanomolar affinities, novel synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0ddf757a46bcc27838837a8e01d01b
https://doi.org/10.1021/jm9904396
https://doi.org/10.1021/jm9904396
Autor:
Ruth W. Yuan, Mihai Azimioara, William C. Shakespeare, Regine S. Bohacek, David C. Dalgarno, Laura Madden, Surinder S. Narula, Martyn C. Botfield, Dennis A. Holt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:3109-3112
A CuBr-mediated, regioselective cross-coupling between methyl 2,5-diiodobenzoate (4) and [(diethoxyphosphinyl)difluoromethyl]zinc bromide is reported. Palladium-catalyzed incorporation of an amino acid side chain, followed by subsequent modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c20e35200b2ea4814641b6139a093a81
https://doi.org/10.1016/s0960-894x(99)00545-4
https://doi.org/10.1016/s0960-894x(99)00545-4
Autor:
Jennifer L. Karas, O. M. Green, Surinder S. Narula, Martyn C. Botfield, TB Philips, Ruth W. Yuan, Ellen R. Laird, Marcos Hatada, David C. Dalgarno, Susan Adams, Mark J. Zoller, Lynne D. Zydowsky, Jeremy Green
Publikováno v:
Structure. 3:1061-1073
Background: Recruitment of the intracellular tyrosine kinase Syk to activated immune-response receptors is a critical early step in intracellular signaling. In mast cells, Syk specifically associates with doubly phosphorylated immunoreceptor tyrosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd462cdc1eb7aa6b8d73ed28b5415890
https://doi.org/10.1016/s0969-2126(01)00242-8
https://doi.org/10.1016/s0969-2126(01)00242-8
Publikováno v:
Biochemistry. 34:620-631
Metallothionein is a cysteine-rich metal-binding protein whose biosynthesis is closely regulated by the level of exposure of an organism to zinc, copper, cadmium, and other metal salts. The metallothionein from Callinectes sapidus is known to bind si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98375bfe48d8cd9af81008797868ab43
https://doi.org/10.1021/bi00002a029
https://doi.org/10.1021/bi00002a029
Publikováno v:
Biochemistry. 32:6773-6787
Complete 1H NMR sequential assignments have been made for copper(I)- and silver (I)-substituted metallothionein (MT) from Saccharomyces cerevisiae using standard 2D 1H NMR methods. The fingerprint region of the COSY spectrum of both metalloproteins s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bded927424b59609931a3ebca2bc2026
https://doi.org/10.1021/bi00077a032
https://doi.org/10.1021/bi00077a032
Autor:
Regine S. Bohacek, Xiaode Lu, John L. Buchanan, George P. Luke, Ruth W. Yuan, Marcos Hatada, David C. Dalgarno, Surinder S. Narula, Dennis A. Holt
Publikováno v:
ChemInform. 30
The structure-based design and synthesis of a novel class of 2,4-disubstituted thiazoles as Src SH2 inhibitors is described. Initial results are presented, including the X-ray and NMR analysis of one thiazole inhibitor bound to Lck and Src SH2.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c19a65203a2112e2a1292cdb6d8f5fdc
https://doi.org/10.1002/chin.199945235
https://doi.org/10.1002/chin.199945235
Autor:
Martyn C. Botfield, Laura Madden, Ruth W. Yuan, David C. Dalgarno, Surinder S. Narula, Regine S. Bohacek, Mihai Azimioara, Dennis A. Holt, William C. Shakespeare
Publikováno v:
ChemInform. 31
A CuBr-mediated, regioselective cross-coupling between methyl 2,5-diiodobenzoate (4) and [(diethoxyphosphinyl)difluoromethyl]zinc bromide is reported. Palladium-catalyzed incorporation of an amino acid side chain, followed by subsequent modifications
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fb4c439fb85b3ed111fc93b0a487884
https://doi.org/10.1002/chin.200008220
https://doi.org/10.1002/chin.200008220