Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Surinder M Soond"'
Autor:
Paul A. Townsend, Maria V. Kozhevnikova, Olivier N. F. Cexus, Andrey A. Zamyatnin, Surinder M. Soond
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-33 (2021)
Abstract The hopeful outcomes from 30 years of research in BH3-mimetics have indeed served a number of solid paradigms for targeting intermediates from the apoptosis pathway in a variety of diseased states. Not only have such rational approaches in d
Externí odkaz:
https://doaj.org/article/8ca444f31899451e9516bb1912adb4ea
Publikováno v:
Zamyatnin, A A, Gregory, L C, Townsend, P A & Soond, S M 2023, ' Beyond basic research : the contribution of cathepsin B to cancer development, diagnosis and therapy ', Expert Opinion on Therapeutic Targets, vol. 26, no. 11, pp. 963-977 . https://doi.org/10.1080/14728222.2022.2161888
INTRODUCTION: In view of other candidate proteins from the cathepsin family of proteases holding great potential in being targeted during cancer therapy, the importance of Cathepsin B (CtsB) stands out as being truly exceptional. Based on its contrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e41d8c53135014f8a9f7a4f37ddd81d4
https://doi.org/10.1080/14728222.2022.2161888
https://doi.org/10.1080/14728222.2022.2161888
Autor:
Anton S Antishin, Svetlana I Erdes, Lyudmila V Savvateeva, Surinder M Soond, Andrey A Zamyatnin
Publikováno v:
Journal of Paediatrics and Child Health. 58:1803-1810
Coeliac disease (CD) is a chronic digestive disorder which presents in diverse ways and is under-diagnosed. The purpose of this study was to provide insights into suspected CD among Russian schoolchildren, through defining the percentage of participa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7161b7fee8d07e24b2e274d99c84881c
https://doi.org/10.1111/jpc.16109
https://doi.org/10.1111/jpc.16109
Autor:
Surinder M. Soond, Maria V. Kozhevnikova, Lyudmila V. Savvateeva, Paul A. Townsend, Andrey A. Zamyatnin
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4669 (2021)
Taken with the growing importance of cathepsin-mediated substrate proteolysis in tumor biology and progression, the focus and emphasis placed on therapeutic design and development is coming into fruition. Underpinning this approach is the invariable
Externí odkaz:
https://doaj.org/article/1fff06b4367f4c2c82fbd2934376486a
Autor:
Surinder M. Soond, Lyudmila V. Savvateeva, Vladimir A. Makarov, Neonila V. Gorokhovets, Paul A. Townsend, Andrey A. Zamyatnin
Publikováno v:
Pharmaceutics, Vol 13, Iss 3, p 339 (2021)
Certain lysosomal cathepsin proteins have come into focus as being good candidates for therapeutic targeting, based on them being over-expressed in a variety of cancers and based on their regulation of the apoptotic pathway. Here, we report novel fin
Externí odkaz:
https://doaj.org/article/e14d638db2e841efae981533fbbe4f24
Autor:
Anastasia S. Frolova, Anastasiia I. Petushkova, Vladimir A. Makarov, Surinder M. Soond, Andrey A. Zamyatnin
Publikováno v:
Biology, Vol 9, Iss 12, p 480 (2020)
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are responsible for the degradation of a wide range of extracellular matrix proteins, which are involved in many cellular processes to ensure the normal development of tissues an
Externí odkaz:
https://doaj.org/article/f663a989c83a4edeaec1fe6c9a1099bb
Publikováno v:
Antibiotics, Vol 8, Iss 4, p 230 (2019)
In the context of a post-antibiotic era, the phenomenon of microbial allolysis, which is defined as the partial killing of bacterial population induced by other cells of the same species, may take on greater significance. This phenomenon was revealed
Externí odkaz:
https://doaj.org/article/1a5ab303121247b29ba55cfcb4cc6413
Autor:
Lloyd C. Wahl, Jessica E. Watt, Hiu T. T. Yim, Danielle De Bourcier, James Tolchard, Surinder M. Soond, Tharin M. A. Blumenschein, Andrew Chantry
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 19, p 4682 (2019)
WWP2 is an E3 ubiquitin ligase that differentially regulates the contextual tumour suppressor/progressor TGFβ signalling pathway by alternate isoform expression. WWP2 isoforms select signal transducer Smad2/3 or inhibitor Smad7 substrates for degrad
Externí odkaz:
https://doaj.org/article/68069bc79ffa4f51917ce66ebb46a0d6
Autor:
Magdalena Rudzińska, Alessandro Parodi, Surinder M. Soond, Andrey Z. Vinarov, Dmitry O. Korolev, Andrey O. Morozov, Cenk Daglioglu, Yusuf Tutar, Andrey A. Zamyatnin
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3602 (2019)
Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of d
Externí odkaz:
https://doaj.org/article/dac1428bd469407597e79598fb4ada34
Publikováno v:
Pharmaceuticals, Vol 12, Iss 2, p 87 (2019)
In keeping with recent developments in basic research; the importance of the Cathepsins as targets in cancer therapy have taken on increasing importance and given rise to a number of key areas of interest in the clinical setting. In keeping with driv
Externí odkaz:
https://doaj.org/article/f91b671e52694308a71bb684b1017732