Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Surin K. Mong"'
Autor:
Bradley L. Pentelute, Obadiah Joseph Plante, Hamid Tissire, Guillaume Lautrette, Zachary Shriver, Faycal Touti, Surin K. Mong, Alexander J. Mijalis, Andrew M. Wollacott, James C. Delaney, Kenneth D. Johnson, Karthik Viswanathan
Publikováno v:
ChemBioChem. 19:2039-2044
To combat antimicrobial infections, new active molecules are needed. Antimicrobial peptides, ever abundant in nature, are a fertile starting point to develop new antimicrobial agents but suffer from low stability, low specificity, and off-target toxi
Autor:
Frank V. Cochran, Hongtao Yu, Bradley L. Pentelute, Yu-Shan Lin, Surin K. Mong, Zachary Graziano, Jennifer R. Cochran
Publikováno v:
Biochemistry. 56:5720-5725
Homochirality is a general feature of biological macromolecules, and Nature includes few examples of heterochiral proteins. Herein, we report on the design, chemical synthesis, and structural characterization of heterochiral proteins possessing loops
Autor:
Mark D. Simon, Alexander A. Vinogradov, Eric A. Standley, Zi-Ning Choo, Zachary P. Gates, Sarah Z. Tasker, Anthony J. Quartararo, Evan D. Styduhar, Faycal Touti, Kathryn H. Halloran, Jessica Laura Wilson, Surin K. Mong, Alexander J. Mijalis, Anupam Bandyopadhyay, Jessica M. Weber, Timothy F. Jamison, Ethan D. Evans, Bradley L. Pentelute
Publikováno v:
Proceedings of the National Academy of Sciences. 115
Significance Combinatorial protein libraries—prepared via molecular biology-based approaches—are invaluable tools for protein engineering. The inclusion of noncanonical amino acids in such libraries is of considerable interest. However, at presen
Autor:
Rocco L. Policarpo, Surin K. Mong, Alexander A. Vinogradov, Andrea Adamo, Xiaoli Liao, Chi Zhang, Yekui Zou, Xiyuan Li, Klavs F. Jensen, Tatiana Berger, Alexander M. Spokoyny, Bradley L. Pentelute, Patrick L. Heider, Mark D. Simon
Publikováno v:
PMC
A flow-based solid-phase peptide synthesis methodology that enables the incorporation of an amino acid residue every 1.8 min under automatic control or every 3 min under manual control is described. This is accomplished by passing a stream of reagent
Publikováno v:
ChemBioChem. 15:721-733
We report the convergent total synthesis of two proteins: DARPin pE59 and Bacillus amyloliquefaciens RNase (Barnase). Leveraging our recently developed fast-flow peptide-synthesis platform, we rapidly explored numerous conditions for the assembly of
Publikováno v:
Organicbiomolecular chemistry. 14(13)
H2 relaxin is a pleiotropic peptide hormone with clinical potential. Here we report on the reaction and use of hexafluorobenzene as an intramolecular disulfide replacement between Cys10 and Cys15 in the A-chain of H2 relaxin. Using flow-based Fmoc so