The potential clinical value of plasma biomarkers in Alzheimer's disease.

Autor: Blennow K; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Galasko D; Department of Neurosciences, University of California, San Diego, La Jolla, California, USA., Perneczky R; Department of Psychiatry and Psychotherapy, University Hospital of Munich, Munich, Germany.; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Broomhall, Sheffield, UK.; Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College London, London, UK., Quevenco FC; Roche Diagnostics International Ltd, Rotkreuz, Switzerland., van der Flier WM; Department of Neurology, Alzheimer Centre Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.; Amsterdam Neuroscience, Neurodegeneration, Amsterdam UMC, Amsterdam, The Netherlands.; Department of Epidemiology and Data Science, Amsterdam UMC, Amsterdam, The Netherlands., Akinwonmi A; Roche Diagnostics International Ltd, Rotkreuz, Switzerland., Carboni M; Roche Diagnostics International Ltd, Rotkreuz, Switzerland., Jethwa A; Roche Diagnostics GmbH, Penzberg, Germany., Suridjan I; Roche Diagnostics International Ltd, Rotkreuz, Switzerland., Zetterberg H; Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; UK Dementia Research Institute, UCL, London, UK.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong Special Administrative Region, Hong Kong, China.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2023 Dec; Vol. 19 (12), pp. 5805-5816. Date of Electronic Publication: 2023 Sep 11.

Large-scale proteome and metabolome analysis of CSF implicates altered glucose and carbon metabolism and succinylcarnitine in Alzheimer's disease.

Autor: Panyard DJ; Department of Population Health Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., McKetney J; National Center for Quantitative Biology of Complex Systems, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA., Deming YK; Department of Population Health Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Morrow AR; Department of Population Health Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA., Ennis GE; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Jonaitis EM; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison, Madison, Wisconsin, USA., Van Hulle CA; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA., Yang C; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, USA., Sung YJ; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, USA., Ali M; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, USA., Kollmorgen G; Roche Diagnostics GmbH, Penzberg, Germany., Suridjan I; Roche Diagnostics International Ltd, Rotkreuz, Switzerland., Bayfield A; Roche Diagnostics GmbH, Penzberg, Germany., Bendlin BB; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison, Madison, Wisconsin, USA.; William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; UK Dementia Research Institute at UCL, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Cruchaga C; Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.; NeuroGenomics and Informatics Center, Washington University School of Medicine, St. Louis, Missouri, USA.; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, Missouri, USA., Carlsson CM; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison, Madison, Wisconsin, USA.; William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA., Johnson SC; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison, Madison, Wisconsin, USA.; William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA., Asthana S; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Medicine, University of Wisconsin-Madison, Madison, Wisconsin, USA.; William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin, USA., Coon JJ; National Center for Quantitative Biology of Complex Systems, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Biomolecular Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Morgridge Institute for Research, Madison, Wisconsin, USA.; Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin, USA., Engelman CD; Department of Population Health Sciences, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2023 Dec; Vol. 19 (12), pp. 5447-5470. Date of Electronic Publication: 2023 May 22.

Neuroimaging of tissue microstructure as a marker of neurodegeneration in the AT(N) framework: defining abnormal neurodegeneration and improving prediction of clinical status.

Autor: Gallagher RL; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; Medical Scientist Training Program, University of Wisconsin-Madison, Madison, WI, USA.; Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA., Koscik RL; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA.; Wisconsin Alzheimer's Institute, Madison, WI, USA., Moody JF; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA.; Wisconsin Alzheimer's Institute, Madison, WI, USA., Vogt NM; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; Medical Scientist Training Program, University of Wisconsin-Madison, Madison, WI, USA.; Neuroscience Training Program, University of Wisconsin-Madison, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA., Adluru N; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA.; Waisman Research Center, Madison, WI, USA., Kecskemeti SR; Waisman Research Center, Madison, WI, USA., Van Hulle CA; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA., Chin NA; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA., Asthana S; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA.; Veterans Administration, Madison, WI, USA., Kollmorgen G; Roche Diagnostics GmbH, Penzberg, Germany., Suridjan I; Roche Diagnostics International Ltd, Rotkreuz, Switzerland., Carlsson CM; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA.; Wisconsin Alzheimer's Institute, Madison, WI, USA.; Veterans Administration, Madison, WI, USA., Johnson SC; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA.; Wisconsin Alzheimer's Institute, Madison, WI, USA.; Veterans Administration, Madison, WI, USA., Dean DC 3rd; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; Waisman Research Center, Madison, WI, USA., Zetterberg H; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA.; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.; UK Dementia Research Institute at UCL, London, UK., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Alexander AL; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.; Waisman Research Center, Madison, WI, USA., Bendlin BB; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. bbb@medicine.wisc.edu.; Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA. bbb@medicine.wisc.edu.; Wisconsin Alzheimer's Institute, Madison, WI, USA. bbb@medicine.wisc.edu.

Publikováno v: Alzheimer's research & therapy [Alzheimers Res Ther] 2023 Oct 17; Vol. 15 (1), pp. 180. Date of Electronic Publication: 2023 Oct 17.

Neuropathology-based APOE genetic risk score better quantifies Alzheimer's risk.

Autor: Deming Y; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Vasiljevic E; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, Wisconsin, USA., Morrow A; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Miao J; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Van Hulle C; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Jonaitis E; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Institute, University of Wisconsin-Madison, Madison, Wisconsin, USA., Ma Y; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Whitenack V; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Kollmorgen G; Roche Diagnostics GmbH, Penzberg, Germany., Wild N; Roche Diagnostics GmbH, Penzberg, Germany., Suridjan I; Roche Diagnostics International Ltd, Rotkreuz, Switzerland., Shaw LM; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA., Asthana S; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; William S. Middleton Memorial Veterans Hospital, Geriatric Research Education and Clinical Center, Madison, Wisconsin, USA., Carlsson CM; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; William S. Middleton Memorial Veterans Hospital, Geriatric Research Education and Clinical Center, Madison, Wisconsin, USA., Johnson SC; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; William S. Middleton Memorial Veterans Hospital, Geriatric Research Education and Clinical Center, Madison, Wisconsin, USA., Zetterberg H; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.; UK Dementia Research Institute at UCL, London, UK.; Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.; Hong Kong Center for Neurodegenerative Diseases, Hong Kong, China., Blennow K; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.; Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden., Bendlin BB; Department of Medicine, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA., Lu Q; Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA., Engelman CD; Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Wisconsin Alzheimer's Disease Research Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.; Center for Demography of Health and Aging, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2023 Aug; Vol. 19 (8), pp. 3406-3416. Date of Electronic Publication: 2023 Feb 16.

Current Diagnostic Pathways for Alzheimer's Disease: A Cross-Sectional Real-World Study Across Six Countries.

Autor: Roth S; Roche Diagnostics International Ltd, Rotkreuz, Switzerland., Burnie N; General Practice, South West London CCG, London, UK., Suridjan I; Roche Diagnostics International Ltd, Rotkreuz, Switzerland., Yan JT; Roche Diagnostics, Santa Clara, CA, USA., Carboni M; Roche Diagnostics International Ltd, Rotkreuz, Switzerland.

Publikováno v: Journal of Alzheimer's disease reports [J Alzheimers Dis Rep] 2023 Jun 29; Vol. 7 (1), pp. 659-674. Date of Electronic Publication: 2023 Jun 29 (Print Publication: 2023).