Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Sureshbabu Nagarajan"'
Autor:
Courtney Sutton, Kaori Nozawa, Katarzyna Kent, Alexander Saltzman, Mei Leng, Sureshbabu Nagarajan, Anna Malovannaya, Masahito Ikawa, Thomas X. Garcia, Martin M. Matzuk
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The quest for a non-hormonal male contraceptive pill for men still exists. Serine protease 37 (PRSS37) is a sperm-specific protein that when ablated in mice renders them sterile. In this study we sought to examine the molecular sequelae of P
Externí odkaz:
https://doaj.org/article/5650f341af6d45c5a09035bc01695750
Autor:
Senthilkumar Muthusamy, Sripriya Ramasamy, Jayanthi Jayaprakash, Jayaraj Santiyagu Savarimuthu, Asha V Nath, Sureshbabu Nagarajan, Ragunathan Manikavali Gurunadhan
Publikováno v:
Journal of Biomedical Materials Research Part B: Applied Biomaterials. 110:535-546
Bacterial infection remains a great challenge in wound healing, especially in chronic wounds. Multidrug-resistant organisms are increasing in acute and chronic wound infections, which compromise the chance of therapeutics. Resistance to conventional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ba41f2b388a9f72d3f7239308d9922
https://doi.org/10.1002/jbm.b.34933
https://doi.org/10.1002/jbm.b.34933
Autor:
Ram K. Modukuri, Zhifeng Yu, Zhi Tan, Hai Minh Ta, Melek Nihan Ucisik, Zhuang Jin, Justin L. Anglin, Kiran L. Sharma, Pranavanand Nyshadham, Feng Li, Kevin Riehle, John C. Faver, Kevin Duong, Sureshbabu Nagarajan, Nicholas Simmons, Stephen S. Palmer, Mingxing Teng, Damian W. Young, Joanna S. Yi, Choel Kim, Martin M. Matzuk
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(22)
BRDT, BRD2, BRD3, and BRD4 comprise the bromodomain and extraterminal (BET) subfamily which contain two similar tandem bromodomains (BD1 and BD2). Selective BD1 inhibition phenocopies effects of tandem BET BD inhibition both in cancer models and, as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a851d4e692ff7c8340bbbd30abba30
https://pubmed.ncbi.nlm.nih.gov/35622893
https://pubmed.ncbi.nlm.nih.gov/35622893
Autor:
Justin L. Anglin, Kevin Riehle, John C. Faver, Marta Storl-Desmond, Rajesh Sharma, Damian W. Young, Melek N. Ucisik, Gundeep Kaur, Feng Li, Choel Kim, Kiran L. Sharma, Nicholas Simmons, Zhifeng Yu, Sureshbabu Nagarajan, Martin M. Matzuk, Pranavanand Nyshadham, Stephen Palmer, Banumathi Sankaran, Angela F. Ku
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 9
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America
Significance There is no nonhormonal contraceptive pill for men, although hundreds of genes have been identified to play roles during spermatogenesis and fertilization in the male reproductive tract. To address the absence of contraceptive drugs for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a47b29b36c4d8ecbdaff9fff6156c7c
https://escholarship.org/uc/item/9t49g9fr
https://escholarship.org/uc/item/9t49g9fr
Autor:
Vladimir N. Uversky, Guy A. Caldwell, Runhua Shi, Wayne O Hemphill, Dhaval Patel, Sureshbabu Nagarajan, Stephan N. Witt, Zhengchang Liu, Kim A. Caldwell, Chuan Xu
Publikováno v:
Human Molecular Genetics. 27:1514-1532
We probed the role of alpha-synuclein (α-syn) in modulating sorting nexin 3 (Snx3)-retromer-mediated recycling of iron transporters in Saccharomyces cerevisiae and Caenorhabditis elegans. In yeast, the membrane-bound heterodimer Fet3/Ftr1 is the hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37881d5b6e7428cc79bb5f3677912fce
https://doi.org/10.1093/hmg/ddy059
https://doi.org/10.1093/hmg/ddy059
Publikováno v:
ChemPhysChem. 17:3470-3479
The rate of reconfiguration-or intramolecular diffusion-of monomeric Alzheimer (Aβ) peptides is measured and, under conditions that aggregation is more likely, peptide diffusion slows down significantly, which allows bimolecular associations to be i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68b8cd9a1aa1f87e265f464c1b93f96
https://doi.org/10.1002/cphc.201600706
https://doi.org/10.1002/cphc.201600706
Publikováno v:
The Journal of Physical Chemistry Letters. 7:3365-3370
The mechanism of protein insertion into a lipid bilayer is poorly understood because the kinetics of this process is difficult to measure. We developed a new approach to study insertion of the antimicrobial peptide Mastoparan X into zwitterionic lipi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891461571d2eb642f00e075b5711aab6
https://doi.org/10.1021/acs.jpclett.6b01512
https://doi.org/10.1021/acs.jpclett.6b01512
Publikováno v:
The journal of physical chemistry. B, vol 122, iss 49
Small single domain proteins that fold on the microsecond time scale have been the subject of intense interest as models for probing the complexity of folding energy landscapes. The villin headpiece subdomain (HP36) has been extensively studied becau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::825d49c968c0bd83e153457f9d1b5691
https://europepmc.org/articles/PMC6395539/
https://europepmc.org/articles/PMC6395539/
Publikováno v:
Journal of Applied Pharmaceutical Science. :153-158
Over the past 3 decades, despite enormous scientific advancements and developments in the field of vaccine development and drugs, HIV-1 is still posing a major challenge to human health. While development of vaccines is still clearly many years ahead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70bc793fb263483679519e0e71a1edff
https://doi.org/10.7324/japs.2015.50928
https://doi.org/10.7324/japs.2015.50928
Autor:
Lisa J. Lapidus, Sureshbabu Nagarajan
The aggregation of intrinsically disordered and misfolded proteins in the form of oligomers and fibrils plays a crucial role in a number of neurological and neurodegenerative diseases. Currently, most probes and biophysical techniques that detect and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa23ea37c5901a4cd3164a7a38ec3694
https://europepmc.org/articles/PMC5806135/
https://europepmc.org/articles/PMC5806135/