Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Suresh Selvaraj Palaniyandi"'
Autor:
Insha Zahoor, Guodong Pan, Mirela Cerghet, Tamer Elbayoumi, Yang Mao-Draayer, Shailendra Giri, Suresh Selvaraj Palaniyandi
Publikováno v:
Heliyon, Vol 10, Iss 15, Pp e35753- (2024)
Autoimmune diseases, including multiple sclerosis (MS), are proven to increase the likelihood of developing cardiovascular disease (CVD) due to a robust systemic immune response and inflammation. MS can lead to cardiovascular abnormalities that are r
Externí odkaz:
https://doaj.org/article/77c93c8d1b9744ea81108dc5f38ad409
Autor:
Rahul Neupane, Katarzyna A. Cieslik, Keith Youker, Suresh Selvaraj Palaniyandi, Ashrith Guha, Rajarajan A. Thandavarayan
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 9, Pp n/a-n/a (2022)
Externí odkaz:
https://doaj.org/article/f32b05aa869747ec8b68abce06c74948
Publikováno v:
Cell & Bioscience, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract According to the World Health Organization, metabolic syndrome (MetS) can be defined as a pathological condition characterized by abdominal obesity, insulin resistance, hypertension, and hyperlipidemia. The incidence of MetS keeps rising, as
Externí odkaz:
https://doaj.org/article/fb5d92da8935401ab654391f091fd311
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 18 (2021)
Background Aldehyde dehydrogenase‐2 (ALDH2), a mitochondrial enzyme, detoxifies reactive aldehydes such as 4‐hydroxy‐2‐nonenal (4HNE). A highly prevalent E487K mutation in ALDH2 (ALDH2*2) in East Asian people with intrinsic low ALDH2 activity
Externí odkaz:
https://doaj.org/article/6d08815a1b214cd8b9cf068fc03d0cf9
Autor:
Guodong Pan, Bipradas Roy, Shailendra Giri, David E. Lanfear, Rajarajan A. Thandavarayan, Ashrith Guha, Pablo A. Ortiz, Suresh Selvaraj Palaniyandi
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 18, p 10439 (2022)
To ameliorate diabetes mellitus-associated heart failure with preserved ejection fraction (HFpEF), we plan to lower diabetes-mediated oxidative stress-induced 4-hydroxy-2-nonenal (4HNE) accumulation by pharmacological agents that either decrease 4HNE
Externí odkaz:
https://doaj.org/article/1643a93fb76d4eecaf0366c5b1d9771b
Autor:
Bipradas Roy, Zhao Yang, Guodong Pan, Katherine Roth, Manisha Agarwal, Rahul Sharma, Michael C. Petriello, Suresh Selvaraj Palaniyandi
Publikováno v:
Toxics, Vol 10, Iss 6, p 328 (2022)
Exposure to environmental pollutants, including dioxin-like polychlorinated biphenyls (PCBs), play an important role in vascular inflammation and cardiometabolic diseases (CMDs) by inducing oxidative stress. Earlier, we demonstrated that oxidative st
Externí odkaz:
https://doaj.org/article/db869558e8bb49788bb2e3c8ffeb43cc
Autor:
Guodong Pan, Srikar Munukutla, Ananya Kar, Joseph Gardinier, Rajarajan A Thandavarayan, Suresh Selvaraj Palaniyandi
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195796 (2018)
E487K point mutation of aldehyde dehydrogenase (ALDH) 2 (ALDH2*2) in East Asians intrinsically lowers ALDH2 activity. ALDH2*2 is associated with diabetic cardiomyopathy. Diabetic patients exhibit heart failure of preserved ejection fraction (HFpEF) i
Externí odkaz:
https://doaj.org/article/edb4fed6f5dd490ab69992be4c2be93a
Autor:
Guodong Pan, Srikar Munukutla, Ananya Kar, Joseph Gardinier, Rajarajan A Thandavarayan, Suresh Selvaraj Palaniyandi
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0203581 (2018)
[This corrects the article DOI: 10.1371/journal.pone.0195796.].
Externí odkaz:
https://doaj.org/article/8696c9796dfa4f469317138dde1fedd4
Publikováno v:
Journal of Diabetes Research, Vol 2016 (2016)
Aldehyde dehydrogenase (ALDH) gene superfamily consists of 19 isozymes. They are present in various organs and involved in metabolizing aldehydes that are biologically generated. For instance, ALDH2, a cardiac mitochondrial ALDH isozyme, is known to
Externí odkaz:
https://doaj.org/article/1b0790a4d7bf4d44a49b82adc06aa9d5
Autor:
Bipradas Roy, Guodong Pan, Shailendra Giri, Rajarajan A. Thandavarayan, Suresh Selvaraj Palaniyandi
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 36(8)
4-hydroxy-2-nonenal (4HNE), an oxidative stress byproduct, is elevated in diabetes which decreases coronary angiogenesis, and this was rescued by the 4HNE detoxifying enzyme, aldehyde dehydrogenase 2 (ALDH2). Adiponectin (APN), an adipocytokine, has