Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Suresh Ramanathan"'
Autor:
Joseph R. Testa, Siddharth Balachandran, Raja M. Flores, Suresh C. Jhanwar, Suresh Ramanathan, Eric A. Ross, Lauren A. Fox, Vladimir Khazak, Ting Zhang, Anna-Mariya Kukuyan, Craig W. Menges, Suraj Peri, Mitchell Cheung, Eleonora Sementino, Yinfei Tan
Expression of RIPK3 induced activation of MLKL and cell death, which was rescued by treatment with GSK'872. Transduction of M12 cells (C) and M22 cells (D) with lentivirus expressing shMLKL or shGFP and then selected for 72 h with puromycin. Stable c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540a97431a764e12de33ff19d33b53ac
https://doi.org/10.1158/1078-0432.22473981.v1
https://doi.org/10.1158/1078-0432.22473981.v1
Autor:
Joseph R. Testa, Siddharth Balachandran, Raja M. Flores, Suresh C. Jhanwar, Suresh Ramanathan, Eric A. Ross, Lauren A. Fox, Vladimir Khazak, Ting Zhang, Anna-Mariya Kukuyan, Craig W. Menges, Suraj Peri, Mitchell Cheung, Eleonora Sementino, Yinfei Tan
Drug sensitivity differences between 12 RIPK3-negative and 3 RIPK3-positive human MM cell lines as assessed by MTS assay. Treatment of MM cell lines with three different doses of doxorubicin. First three bars in each bar graph represent viability of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180be1fc59a050efb09c29d30fe92446
https://doi.org/10.1158/1078-0432.22473972
https://doi.org/10.1158/1078-0432.22473972
Autor:
Joseph R. Testa, Siddharth Balachandran, Raja M. Flores, Suresh C. Jhanwar, Suresh Ramanathan, Eric A. Ross, Lauren A. Fox, Vladimir Khazak, Ting Zhang, Anna-Mariya Kukuyan, Craig W. Menges, Suraj Peri, Mitchell Cheung, Eleonora Sementino, Yinfei Tan
Re-expression of RIPK3 expression triggers necroptosis in RIPK3-negative MM cell lines, and RIPK3 inhibition rescues the cell death caused by necroptosis. A, RIPK3-negative MM cell lines M12 and M22 were transduced with WPI lentivirus expressing RIPK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317b842c6666ebef0fa2d87347aada90
https://doi.org/10.1158/1078-0432.22473987
https://doi.org/10.1158/1078-0432.22473987
Autor:
Joseph R. Testa, Siddharth Balachandran, Raja M. Flores, Suresh C. Jhanwar, Suresh Ramanathan, Eric A. Ross, Lauren A. Fox, Vladimir Khazak, Ting Zhang, Anna-Mariya Kukuyan, Craig W. Menges, Suraj Peri, Mitchell Cheung, Eleonora Sementino, Yinfei Tan
Efficiency of infection of MM cell lines infected with a pWPI lentivirus that expresses GFP marker alone (pWPI, control) or with a pWPI lentivirus that expresses both GFP and either RIPK3 WT or RIPK3-KD. Representative images indicate efficiency of i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9e0edd54884d572354a11018cea775
https://doi.org/10.1158/1078-0432.22474002
https://doi.org/10.1158/1078-0432.22474002
Autor:
Joseph R. Testa, Siddharth Balachandran, Raja M. Flores, Suresh C. Jhanwar, Suresh Ramanathan, Eric A. Ross, Lauren A. Fox, Vladimir Khazak, Ting Zhang, Anna-Mariya Kukuyan, Craig W. Menges, Suraj Peri, Mitchell Cheung, Eleonora Sementino, Yinfei Tan
Human malignant mesothelioma (MM) cell lines frequently show down regulated expression of RIPK3 protein. Western blotting illustrating RIPK3 protein expression in 20 human MM cell lines. Normal mesothelial cell line NM311A was used as a control.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1515f9d1e03a9e787a5fc1b6f456a445
https://doi.org/10.1158/1078-0432.22473993
https://doi.org/10.1158/1078-0432.22473993
Autor:
Joseph R. Testa, Siddharth Balachandran, Raja M. Flores, Suresh C. Jhanwar, Suresh Ramanathan, Eric A. Ross, Lauren A. Fox, Vladimir Khazak, Ting Zhang, Anna-Mariya Kukuyan, Craig W. Menges, Suraj Peri, Mitchell Cheung, Eleonora Sementino, Yinfei Tan
Lentivirus plasmids expressing shMLKL.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c152e6f686b7519e3d25c76c8d0a356
https://doi.org/10.1158/1078-0432.22473960.v1
https://doi.org/10.1158/1078-0432.22473960.v1
Autor:
Joseph R. Testa, Siddharth Balachandran, Raja M. Flores, Suresh C. Jhanwar, Suresh Ramanathan, Eric A. Ross, Lauren A. Fox, Vladimir Khazak, Ting Zhang, Anna-Mariya Kukuyan, Craig W. Menges, Suraj Peri, Mitchell Cheung, Eleonora Sementino, Yinfei Tan
Re-expression of RIPK3 induces necrosis of RIPK3-negative MM cells. M8, M12, M17 and MSTO211H cells were transduced with control WPI lentivirus or WPI lentivirus expressing RIPK3 cDNA for 24 hours before seeding in 96-well plates and assaying for cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2b741abe6800b4b247bfaacaee2fcb
https://doi.org/10.1158/1078-0432.22473978
https://doi.org/10.1158/1078-0432.22473978
Autor:
Joseph R. Testa, Siddharth Balachandran, Raja M. Flores, Suresh C. Jhanwar, Suresh Ramanathan, Eric A. Ross, Lauren A. Fox, Vladimir Khazak, Ting Zhang, Anna-Mariya Kukuyan, Craig W. Menges, Suraj Peri, Mitchell Cheung, Eleonora Sementino, Yinfei Tan
DNA methyltransferase DNMT1 suppresses RIPK3 transcription. A, Immunoblot analysis of MM cells with knockdown of DNMT1 protein (184 kDa) expression. RIPK3-negative cells were transfected with two siRNAs against DNMT1 or an siControl (siCon), and DNMT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e75c99eb3cf83519324807c6257fdf8
https://doi.org/10.1158/1078-0432.22474011.v1
https://doi.org/10.1158/1078-0432.22474011.v1
Autor:
Joseph R. Testa, Siddharth Balachandran, Raja M. Flores, Suresh C. Jhanwar, Suresh Ramanathan, Eric A. Ross, Lauren A. Fox, Vladimir Khazak, Ting Zhang, Anna-Mariya Kukuyan, Craig W. Menges, Suraj Peri, Mitchell Cheung, Eleonora Sementino, Yinfei Tan
Purpose:Receptor-interacting protein kinase 3 (RIPK3) phosphorylates effector molecule MLKL to trigger necroptosis. Although RIPK3 loss is seen in several human cancers, its role in malignant mesothelioma is unknown. This study aimed to determine whe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663c4bcc302fb64fbca4097e28ff7bd1
https://doi.org/10.1158/1078-0432.c.6528651.v1
https://doi.org/10.1158/1078-0432.c.6528651.v1
Autor:
Joseph R. Testa, Siddharth Balachandran, Raja M. Flores, Suresh C. Jhanwar, Suresh Ramanathan, Eric A. Ross, Lauren A. Fox, Vladimir Khazak, Ting Zhang, Anna-Mariya Kukuyan, Craig W. Menges, Suraj Peri, Mitchell Cheung, Eleonora Sementino, Yinfei Tan
Patient background information for 27 primary pleural malignant mesothelioma (MM) samples used in this investigation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4be54f29b87e3b7d546ca97fb76862
https://doi.org/10.1158/1078-0432.22473966
https://doi.org/10.1158/1078-0432.22473966