Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Suresh R. Babu"'
Publikováno v:
Pharmaceutical Development and Technology. 10:451-460
Micronization is a commonly used enabling technology to improve the bioavailability of compounds where absorption is dissolution rate limited. However, decreasing particle size often results in increased Van der Waals' interactions and electrostatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b3d550f87b9f6d0dcbae54e6c61c3f
https://doi.org/10.1080/10837450500299636
https://doi.org/10.1080/10837450500299636
Autor:
James A. Wesley, Bienvenido Ruiz, Suresh R. Babu, Shobha N. Bhattachar, Korey Bahash, Chen Linna R
Publikováno v:
Pharmaceutical Research. 20:797-801
Purpose. To investigate the mechanism by which Tween 80 impedes the dissolution of CI-1041, a poorly water-soluble compound in its free form. Methods. Bulk powder and intrinsic dissolution (ID) of CI-1041 in 0.1 N HCl with various concentrations of T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a0e1b5f3e780a8949e6d6701a5433e1
https://doi.org/10.1023/a:1023493821302
https://doi.org/10.1023/a:1023493821302
Publikováno v:
International Journal of Pharmaceutics. 128:29-44
CI-976 (2,2-dimethyl-N-[2,4,6-trimethoxyphenyl]dodecanamide) was used as a model compound to study the interaction of surfactant solutions with a drug surface because of its high degree of hydrophobicity and low solubility. The advancing contact angl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1600aaaa4b02d75a6d1284d944850d95
https://doi.org/10.1016/0378-5173(95)04208-3
https://doi.org/10.1016/0378-5173(95)04208-3
Publikováno v:
Pharmaceutical Research. 11:1755-1760
Physicochemical effects caused by intestinal fluids on drugs in the gastrointestinal (GI) tract can be a contributing factor in food induced changes in bioavailability. To identify physicochemical properties of gemfibrozil that may be altered by endo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91176929565dfb46b25733ce0c8038a1
https://doi.org/10.1023/a:1018967401000
https://doi.org/10.1023/a:1018967401000
Autor:
Linna R, Chen, James A, Wesley, Shobha, Bhattachar, Bienvenido, Ruiz, Korey, Bahash, Suresh R, Babu
Publikováno v:
Pharmaceutical research. 20(5)
To investigate the mechanism by which Tween 80 impedes the dissolution of CI-1041, a poorly water-soluble compound in its free form.Bulk powder and intrinsic dissolution (ID) of CI-1041 in 0.1 N HCl with various concentrations of Tween 80 were conduc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::48d55e052b0b453107c15c5f1eb807f9
https://pubmed.ncbi.nlm.nih.gov/12751636
https://pubmed.ncbi.nlm.nih.gov/12751636
Publikováno v:
International journal of pharmaceutics. 236(1-2)
Dissolution of Pfizer Compound PD198306, a poorly soluble compound, was studied in 25 mM pH 9 sodium phosphate solution with 0.5% SLS using the flow-through cell dissolution apparatus. Unmicronized and micronized drug powders were tested. Several met
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e1f256f834f0c592d92b045a7f85c6
https://pubmed.ncbi.nlm.nih.gov/11891077
https://pubmed.ncbi.nlm.nih.gov/11891077
Publikováno v:
International Journal of Pharmaceutics. 57:95-105
The mechanical properties of a compact are typically measured by destructive tests that examine the mechanical failure properties of compacts. These tests result in irreversible damage to the mechanical structure of the compact and consequently provi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81bc1ca1e2049b075a7858ff8bacd86a
https://doi.org/10.1016/0378-5173(89)90297-4
https://doi.org/10.1016/0378-5173(89)90297-4
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