Zobrazeno 1 - 10
of 104
pro vyhledávání: '"Suresh K. Joseph"'
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101119- (2022)
Summary: This protocol describes how to visualize, detect, and analyze redox signals (oxidative bursts) at the ER-mitochondrial interface. It uses drug-inducible crosslinking to target the genetically encoded glutathione redox sensor Grx1roGFP2 to or
Externí odkaz:
https://doaj.org/article/1134d342c13544f2a7b3b44d93ce631f
Autor:
Adam Bartok, David Weaver, Tünde Golenár, Zuzana Nichtova, Máté Katona, Száva Bánsághi, Kamil J. Alzayady, V. Kaye Thomas, Hideaki Ando, Katsuhiko Mikoshiba, Suresh K. Joseph, David I. Yule, György Csordás, György Hajnóczky
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Membrane contact sites between the ER and mitochondria are known to convey calcium signals between these two organelles via IP3 receptors, but the molecular mechanisms are currently unclear. Here, the authors show that IP3 receptors play a structural
Externí odkaz:
https://doaj.org/article/573c9a6e3c934f97817996bbe29c011b
Autor:
Lawrence D. Gaspers, Paula J. Bartlett, Antonio Politi, Paul Burnett, Walson Metzger, Jane Johnston, Suresh K. Joseph, Thomas Höfer, Andrew P. Thomas
Publikováno v:
Cell Reports, Vol 9, Iss 4, Pp 1209-1218 (2014)
Receptor-mediated oscillations in cytosolic Ca2+ concentration ([Ca2+]i) could originate either directly from an autonomous Ca2+ feedback oscillator at the inositol 1,4,5-trisphosphate (IP3) receptor or as a secondary consequence of IP3 oscillations
Externí odkaz:
https://doaj.org/article/a06c5cf23af84f0089b0d8c84973e322
Autor:
Aniko Gal, Peter Balicza, David Weaver, Shamim Naghdi, Suresh K Joseph, Péter Várnai, Tibor Gyuris, Attila Horváth, Laszlo Nagy, Erin L Seifert, Maria Judit Molnar, György Hajnóczky
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 8, Pp n/a-n/a (2023)
Externí odkaz:
https://doaj.org/article/05870890e3114cd0a1ae734c6b71f1e0
Autor:
Macarena Rodríguez-Prados, Kai-Ting Huang, Katalin Márta, Melanie Paillard, György Csordás, Suresh K. Joseph, György Hajnóczky
Publikováno v:
Cell Chemical Biology.
Autor:
Dhanendra Tomar, Manfred Thomas, Joanne F. Garbincius, Devin W. Kolmetzky, Oniel Salik, Pooja Jadiya, Suresh K. Joseph, April C. Carpenter, György Hajnóczky, John W. Elrod
Publikováno v:
Science Signaling. 16
MICU1 is a calcium (Ca 2+ )–binding protein that regulates the mitochondrial Ca 2+ uniporter channel complex (mtCU) and mitochondrial Ca 2+ uptake. MICU1 knockout mice display disorganized mitochondrial architecture, a phenotype that is distinct fr
Autor:
Aniko Gal, Peter Balicza, David Weaver, Shamim Naghdi, Suresh K Joseph, Péter Várnai, Tibor Gyuris, Attila Horváth, Laszlo Nagy, Erin L Seifert, Maria Judit Molnar, György Hajnóczky
Publikováno v:
EMBO Molecular Medicine, Vol 9, Iss 7, Pp 967-984 (2017)
Abstract The protein MSTO1 has been localized to mitochondria and linked to mitochondrial morphology, but its specific role has remained unclear. Lactate stress test and myopathological results suggest mitochondrial dysfunction. In patient fibroblast
Externí odkaz:
https://doaj.org/article/479e508ee72849f6be4288a872e463e0
Autor:
Vikas Arige, Lara E. Terry, Larry E. Wagner, Sundeep Malik, Mariah R. Baker, Guizhen Fan, Suresh K. Joseph, Irina I. Serysheva, David I. Yule
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(39)
Inositol 1,4,5-trisphosphate receptors (IP 3 Rs) initiate a diverse array of physiological responses by carefully orchestrating intracellular calcium (Ca 2+ ) signals in response to various external cues. Notably, IP 3 R channel activity is determine
Autor:
Suresh K. Joseph, György Csordás, Tünde Golenár, Katsuhiko Mikoshiba, György Hajnóczky, Zuzana Nichtova, V. Kaye Thomas, David I. Yule, Kamil J. Alzayady, David Weaver, Máté Katona, Hideaki Ando, Adam Bartok, Száva Bánsághi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Contact sites of endoplasmic reticulum (ER) and mitochondria locally convey calcium signals between the IP3 receptors (IP3R) and the mitochondrial calcium uniporter, and are central to cell survival. It remains unclear whether IP3Rs also have a struc
Publikováno v:
Cell Calcium
Physiological signaling by reactive oxygen species (ROS) and their pathophysiological role in cell death are well recognized. This review focuses on two ROS targets that are key to local Ca(2+) signaling at the ER/mitochondrial interface - notably, i