Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Suresh Dharuman"'
Autor:
Daniel C. Scott, Suresh Dharuman, Elizabeth Griffith, Sergio C. Chai, Jarrid Ronnebaum, Moeko T. King, Rajendra Tangallapally, Chan Lee, Clifford T. Gee, Lei Yang, Yong Li, Victoria C. Loudon, Ha Won Lee, Jason Ochoada, Darcie J. Miller, Thilina Jayasinghe, Joao A. Paulo, Stephen J. Elledge, J. Wade Harper, Taosheng Chen, Richard E. Lee, Brenda A. Schulman
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract PROTAC® (proteolysis-targeting chimera) molecules induce proximity between an E3 ligase and protein-of-interest (POI) to target the POI for ubiquitin-mediated degradation. Cooperative E3-PROTAC-POI complexes have potential to achieve neo-su
Externí odkaz:
https://doaj.org/article/6c50c513c918469eaf4c94f0f0e0d58b
Publikováno v:
Molecules, Vol 27, Iss 5, p 1518 (2022)
Infections due to Gram-negative bacteria are increasingly dangerous due to the spread of multi-drug resistant strains, emphasizing the urgent need for new antibiotics with alternative modes of action. We have previously identified a novel class of an
Externí odkaz:
https://doaj.org/article/e98d0e06ad034f5f815f652b5442de18
Publikováno v:
CHIMIA, Vol 66, Iss 12 (2012)
Glycals have been transformed into a variety of functionalized substrates which have been found to be useful in synthesizing some aminosugars, N-glycopeptides, nitrosugars and some iminosugars which are potential glycosidase inhibitors. An account of
Externí odkaz:
https://doaj.org/article/7f8cab3e2803467482f458370a6e51ec
Autor:
Deanna Deveson Lucas, Cornelia B. Landersdorfer, Jürgen B. Bulitta, Tae Hwan Kim, Dhruvitkumar S. Sutaria, Amy Wright, John D. Boyce, Arnold Louie, Alicja J. Copik, Brian T. Tsuji, Herbert P. Schweizer, Michael H. Norris, Miranda J. Wallace, Jeremiah Oyer, Carolin Werkman, Suresh Dharuman, Eric D. LoVullo, Beom Soo Shin, Yinzhi Lang, Xun Tao, Rossie H. Jimenez-Nieves, Brett A. Fleischer, Yuanyuan Jiao, Robert A. Bonomo, Venkataraman Balasubramanian, Kari B. Basso, Eunjeong Shin, Marianne Mégroz, George L. Drusano, Victoria C. Loudon-Hossler, Keisha C. Cadet, Nagakumar Bharatham, Jieqiang Zhou, Stephanie M. Reeve, Bartolomé Moyá, Nirav Shah, Alaa R. M. Sayed, Richard E. Lee
Publikováno v:
Clinical Pharmacology & Therapeutics. 109:1000-1020
Multidrug-resistant bacteria are causing a serious global health crisis. A dramatic decline in antibiotic discovery and development investment by pharmaceutical industry over the last decades has slowed the adoption of new technologies. It is imperat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81d1fd44221b5ffb219142197006572e
https://doi.org/10.1002/cpt.2205
https://doi.org/10.1002/cpt.2205
Autor:
Richard E. Lee, Suresh Dharuman, Jiuyu Liu, Stephanie M. Reeve, Carl W Thompson, Robin B. Lee, John M Elmore, Erik C. Böttger, Laura A. Wilt, Dimitri Shcherbakov
Publikováno v:
Journal of Antibiotics, 74 (6)
The Journal of Antibiotics
The Journal of Antibiotics
Spectinomycin, an aminocyclitol antibiotic, is subject to inactivation by aminoglycoside modifying enzymes (AMEs) through adenylylation or phosphorylation of the 6-hydroxy group position. In this study, the effects of deoxygenation of the 2- and 6-hy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab27dbc8b070686fe8d6a6b4c68320e
https://hdl.handle.net/20.500.11850/488447
https://hdl.handle.net/20.500.11850/488447
Autor:
Elizabeth C. Griffith, Miranda J. Wallace, Stephanie M. Reeve, Clifford T. Gee, Gregory A. Phelps, Robin B. Lee, John M Elmore, Jiangwei Yao, William C. Wright, Richard E. Lee, Taosheng Chen, Dinesh M. Fernando, Suresh Dharuman
Publikováno v:
ACS Infect Dis
Increasing rates of drug-resistant Gram-negative (GN) infections, combined with a lack of new GN-effective antibiotic classes, are driving the need for the discovery of new agents. Bacterial metabolism represents an underutilized mechanism of action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2beef4800bfcf8e9dff91bd728a693b8
https://pubmed.ncbi.nlm.nih.gov/31887254
https://pubmed.ncbi.nlm.nih.gov/31887254
Publikováno v:
The Journal of Organic Chemistry
The synthesis and conformational analysis of a series of phenyl 2,3,6-tri- O-benzyl-β-d-thio galacto- and glucopyranosides and their 6 S-deuterio isotopomers, with systematic variation of the protecting group at the 4-position, are described. For th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04e3be9889db751b9b1bc71dc29388a8
http://europepmc.org/articles/PMC6131524
http://europepmc.org/articles/PMC6131524
Publikováno v:
The Journal of Organic Chemistry. 83:881-897
Hexopyranose side chains populate three staggered conformations, whose proportions can be determined from the three sets of ideal limiting 3JH5,H6R and 3JH5,H6S coupling constants in combination with the time-averaged experimental coupling constants.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::922f93e8277cc5809508c2cd120dfbc8
https://doi.org/10.1021/acs.joc.7b02891
https://doi.org/10.1021/acs.joc.7b02891
Publikováno v:
Tetrahedron: Asymmetry. 27:1088-1100
The synthesis of analogues of hyacinthacine, casuarine and uniflorine A is described. The key steps involved in achieving these targets are the zinc mediated Barbier reaction, vinyl Grignard reaction, dihydroxylation and cyclization. All of the synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8d1a5e1ff42698f0aebc2d2c9ec8d60
https://doi.org/10.1016/j.tetasy.2016.08.017
https://doi.org/10.1016/j.tetasy.2016.08.017
Autor:
Yashwant D. Vankar, Suresh Dharuman
Publikováno v:
Organic Letters. 16:1172-1175
An expedient one-step synthesis of 2-iodoglycals and 2-bromoglycals from glycals using NIS/AgNO3 and NBS/AgNO3 as reagent systems has been developed. The utility of these 2-haloglycals has been demonstrated by converting them into 2C-branched glycals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9016b7e327cd0ae7b634531d65860f5
https://doi.org/10.1021/ol500039s
https://doi.org/10.1021/ol500039s