Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Suresh B Lakshminarayana"'
Autor:
Srinivasa P S Rao, Suresh B Lakshminarayana, Jan Jiricek, Marcel Kaiser, Ryan Ritchie, Elmarie Myburgh, Frantisek Supek, Tove Tuntland, Advait Nagle, Valentina Molteni, Pascal Mäser, Jeremy C Mottram, Michael P Barrett, Thierry T Diagana
Publikováno v:
Tropical Medicine and Infectious Disease, Vol 5, Iss 1, p 28 (2020)
Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and ‘easy to use’ oral drugs. Previously, we reported the discovery of the
Externí odkaz:
https://doaj.org/article/e5e1e471c0c746d79f9d7063a4a2f672
Autor:
Suresh B Lakshminarayana, Helena I M Boshoff, Joseph Cherian, Sindhu Ravindran, Anne Goh, Jan Jiricek, Mahesh Nanjundappa, Amit Nayyar, Meera Gurumurthy, Ramandeep Singh, Thomas Dick, Francesca Blasco, Clifton E Barry, Paul C Ho, Ujjini H Manjunatha
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105222 (2014)
PA-824 is a bicyclic 4-nitroimidazole, currently in phase II clinical trials for the treatment of tuberculosis. Dose fractionation pharmacokinetic-pharmacodynamic studies in mice indicated that the driver of PA-824 in vivo efficacy is the time during
Externí odkaz:
https://doaj.org/article/7f9d4e061d1d44e1bb837ce762cb14e3
Autor:
Rudolf Mueller, Virsinha Reddy, Aloysius T. Nchinda, Fanuel Mebrahtu, Dale Taylor, Nina Lawrence, Lloyd Tanner, Marine Barnabe, Charles J. Eyermann, Bin Zou, Ravinder R. Kondreddi, Suresh B. Lakshminarayana, Matthias Rottmann, Leslie J. Street, Kelly Chibale
Publikováno v:
ACS Omega, Vol 5, Iss 12, Pp 6967-6982 (2020)
Externí odkaz:
https://doaj.org/article/4ad36f674d374ec382c3bc8f6343258f
Autor:
Dennis C. Koester, Vanessa M. Marx, Sarah Williams, Jan Jiricek, Maxime Dauphinais, Olivier René, Sarah L. Miller, Lei Zhang, Debjani Patra, Yen-Liang Chen, Harry Cheung, Jonathan Gable, Suresh B. Lakshminarayana, Colin Osborne, Jean-Rene Galarneau, Upendra Kulkarni, Wendy Richmond, Angela Bretz, Linda Xiao, Frantisek Supek, Christian Wiesmann, Srinivas Honnappa, Celine Be, Pascal Mäser, Marcel Kaiser, Ryan Ritchie, Michael P. Barrett, Thierry T. Diagana, Christopher Sarko, Srinivasa P. S. Rao
Publikováno v:
Journal of Medicinal Chemistry. 65:11776-11787
Human African Trypanosomiasis (HAT) is a vector-borne disease caused by kinetoplastid parasites of the Trypanosoma genus. The disease proceeds in two stages, with a hemolymphatic blood stage and a meningo-encephalic brain stage. In the latter stage,
Autor:
Benjamin R. Taft, Fumiaki Yokokawa, Tom Kirrane, Anne-Catherine Mata, Richard Huang, Nicole Blaquiere, Grace Waldron, Bin Zou, Oliver Simon, Subramanyam Vankadara, Wai Ling Chan, Mei Ding, Sandra Sim, Judith Straimer, Armand Guiguemde, Suresh B. Lakshminarayana, Jay Prakash Jain, Christophe Bodenreider, Christopher Thompson, Christian Lanshoeft, Wei Shu, Eric Fang, Jafri Qumber, Katherine Chan, Luying Pei, Yen-Liang Chen, Hanna Schulz, Jessie Lim, Siti Nurdiana Abas, Xiaoman Ang, Yugang Liu, Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, Francisco Javier Gamo, Benigno Crespo-Fernandez, Philip J. Rosenthal, Roland A. Cooper, Patrick Tumwebaze, Anna Caroline Campos Aguiar, Brice Campo, Simon Campbell, Jürgen Wagner, Thierry T. Diagana, Christopher Sarko
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
A series of 5-aryl-2-amino
Autor:
Haoying Xu, Wei Lin Sandra Sim, Cheah Chen Seh, Feng Wang, Thierry T. Diagana, Wai Ling Chan, Jae-Geun Song, Kah Fei Wan, Bin Zou, Ghislain M. C. Bonamy, David Beer, David T. Barkan, Min Li, Stephanie A. Moquin, Francesca Blasco, Suresh B. Lakshminarayana, Jin Zhang, Oliver Simon, Vito G. Sasseville, Craig W. Day, Qing-Yin Wang, Chandrassegar Saravanan, Katherine Chan, Fumiaki Yokokawa, Bryan K. S. Yeung, Ratna Karuna, Hui-Quan Yeo, Colin Osborne, Christopher Sarko, Pei Yong Shi, Hongping Dong, Mei Ding, Siew Pheng Lim, Yen Liang Chen, Feng Gu, Cyrille Kounde, Gang Wang, Siyan Lu, Wei Liu
Publikováno v:
Science Translational Medicine. 13
Dengue virus (DENV) is a mosquito-borne flavivirus that poses a threat to public health, yet no antiviral drug is available. We performed a high-throughput phenotypic screen using the Novartis compound library and identified candidate chemical inhibi
Autor:
Martijn Fenaux, Andrea Leonardi, Sreehari Babu, Peck Gee Seah, Wei Liu, Pei Yong Shi, Rao P S Srinivasa, Suresh B. Lakshminarayana, Haoying Xu, Jin Zhang, Fumiaki Yokokawa, Cheah Chen Seh, Francesca Blasco, Nahdiyah Abdul Ghafar, Wai Ling Chan, Gang Wang, Ellie Growcott, Feng Gu, Weidong Zhong, Keshi Wang, Mei Ding, Ratna Karuna, Siew Pheng Lim, Yen Liang Chen
Publikováno v:
Antimicrob Agents Chemother
Monophosphate prodrug analogs of 2′-deoxy-2′-fluoro-2′-C-methylguanosine have been reported as potent inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase. These prodrugs also display potent anti-dengue virus activities in cellula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18dd646098b1cf2a7e9cd9dd08f0a432
https://europepmc.org/articles/PMC7674056/
https://europepmc.org/articles/PMC7674056/
Autor:
Wei Liu, Sreehari Babu, Wai Ling Chan, Suresh B. Lakshminarayana, Ellena Growcott, Peck Gee Seah, Martijn Fenaux, Mei Ding, Nahdiyah Abdul Ghafar, Gang Wang, Ratna Karuna, Cheah Chen Seh, Haoying Xu, Feng Gu, Weidong Zhong, Pei Yong Shi, Keshi Wang, Andrea Leonardi, Francesca Blasco, Yen Liang Chen, Srinivasa P. S. Rao, Siew Pheng Lim, Fumiaki Yokokawa, Jin Zhang
Monophosphate prodrug analogs of 2’-deoxy-2’-fluoro-2’-C-methylguanosine have been reported as potent inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase. These prodrugs also display potent anti-dengue activities in cellular assa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8d10b314ef2182303dfcf7c75456ce
Autor:
Thierry T. Diagana, Valentina Molteni, Advait Nagle, Jeremy C. Mottram, Pascal Mäser, Jan Jiricek, Ryan Ritchie, Srinivasa P. S. Rao, Frantisek Supek, Elmarie Myburgh, Marcel Kaiser, Suresh B. Lakshminarayana, Michael P. Barrett, Tove Tuntland
Publikováno v:
Tropical Medicine and Infectious Disease; Volume 5; Issue 1; Pages: 28
Tropical Medicine and Infectious Disease, Vol 5, Iss 1, p 28 (2020)
Tropical Medicine and Infectious Disease
Tropical Medicine and Infectious Disease, Vol 5, Iss 1, p 28 (2020)
Tropical Medicine and Infectious Disease
Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and ‘easy to use’ oral drugs. Previously, we reported the discovery of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15381cfb39d702fc3495d19d79a2bc29
https://eprints.whiterose.ac.uk/157769/1/tropicalmed_05_00028.pdf
https://eprints.whiterose.ac.uk/157769/1/tropicalmed_05_00028.pdf
Autor:
Fanuel Mebrahtu, Leslie J. Street, Marine Barnabe, Rudolf Mueller, Nina Lawrence, Matthias Rottmann, Virsinha Reddy, Aloysius T. Nchinda, Ravinder Reddy Kondreddi, Dale Taylor, Lloyd Tanner, Charles J. Eyermann, Kelly Chibale, Suresh B. Lakshminarayana, Bin Zou
Publikováno v:
ACS Omega
ACS Omega, Vol 5, Iss 12, Pp 6967-6982 (2020)
ACS Omega, Vol 5, Iss 12, Pp 6967-6982 (2020)
A phenotypic whole cell high-throughput screen against the asexual blood and liver stages of the malaria parasite identified a benzimidazole chemical series. Among the hits were the antiemetic benzimidazole drug Lerisetron 1 (IC50 NF54 = 0.81 μM) an