Lerisetron Analogues with Antimalarial Properties: Synthesis, Structure–Activity Relationship Studies, and Biological Assessment

Autor: Rudolf Mueller, Virsinha Reddy, Aloysius T. Nchinda, Fanuel Mebrahtu, Dale Taylor, Nina Lawrence, Lloyd Tanner, Marine Barnabe, Charles J. Eyermann, Bin Zou, Ravinder R. Kondreddi, Suresh B. Lakshminarayana, Matthias Rottmann, Leslie J. Street, Kelly Chibale

Publikováno v: ACS Omega, Vol 5, Iss 12, Pp 6967-6982 (2020)

Externí odkaz: https://doaj.org/article/4ad36f674d374ec382c3bc8f6343258f

Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis

Autor: Srinivasa P S Rao, Suresh B Lakshminarayana, Jan Jiricek, Marcel Kaiser, Ryan Ritchie, Elmarie Myburgh, Frantisek Supek, Tove Tuntland, Advait Nagle, Valentina Molteni, Pascal Mäser, Jeremy C Mottram, Michael P Barrett, Thierry T Diagana

Publikováno v: Tropical Medicine and Infectious Disease, Vol 5, Iss 1, p 28 (2020)

Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and ‘easy to use’ oral drugs. Previously, we reported the discovery of the

Externí odkaz: https://doaj.org/article/e5e1e471c0c746d79f9d7063a4a2f672

Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis.

Autor: Suresh B Lakshminarayana, Helena I M Boshoff, Joseph Cherian, Sindhu Ravindran, Anne Goh, Jan Jiricek, Mahesh Nanjundappa, Amit Nayyar, Meera Gurumurthy, Ramandeep Singh, Thomas Dick, Francesca Blasco, Clifton E Barry, Paul C Ho, Ujjini H Manjunatha

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e105222 (2014)

PA-824 is a bicyclic 4-nitroimidazole, currently in phase II clinical trials for the treatment of tuberculosis. Dose fractionation pharmacokinetic-pharmacodynamic studies in mice indicated that the driver of PA-824 in vivo efficacy is the time during

Externí odkaz: https://doaj.org/article/7f9d4e061d1d44e1bb837ce762cb14e3

A Cyclic Phosphoramidate Prodrug of 2′-Deoxy-2′-Fluoro-2′-C-Methylguanosine for the Treatment of Dengue Virus Infection

Autor: Martijn Fenaux, Andrea Leonardi, Sreehari Babu, Peck Gee Seah, Wei Liu, Pei Yong Shi, Rao P S Srinivasa, Suresh B. Lakshminarayana, Haoying Xu, Jin Zhang, Fumiaki Yokokawa, Cheah Chen Seh, Francesca Blasco, Nahdiyah Abdul Ghafar, Wai Ling Chan, Gang Wang, Ellie Growcott, Feng Gu, Weidong Zhong, Keshi Wang, Mei Ding, Ratna Karuna, Siew Pheng Lim, Yen Liang Chen

Publikováno v: Antimicrob Agents Chemother

Monophosphate prodrug analogs of 2′-deoxy-2′-fluoro-2′-C-methylguanosine have been reported as potent inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase. These prodrugs also display potent anti-dengue virus activities in cellula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18dd646098b1cf2a7e9cd9dd08f0a432
https://europepmc.org/articles/PMC7674056/

Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis

Autor: Thierry T. Diagana, Valentina Molteni, Advait Nagle, Jeremy C. Mottram, Pascal Mäser, Jan Jiricek, Ryan Ritchie, Srinivasa P. S. Rao, Frantisek Supek, Elmarie Myburgh, Marcel Kaiser, Suresh B. Lakshminarayana, Michael P. Barrett, Tove Tuntland

Publikováno v: Tropical Medicine and Infectious Disease; Volume 5; Issue 1; Pages: 28
Tropical Medicine and Infectious Disease, Vol 5, Iss 1, p 28 (2020)
Tropical Medicine and Infectious Disease

Current anti-trypanosomal therapies suffer from problems of longer treatment duration, toxicity and inadequate efficacy, hence there is a need for safer, more efficacious and ‘easy to use’ oral drugs. Previously, we reported the discovery of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15381cfb39d702fc3495d19d79a2bc29
https://eprints.whiterose.ac.uk/157769/1/tropicalmed_05_00028.pdf