Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Suresh, Sudarsan"'
Publikováno v:
Fermentation, Vol 9, Iss 1, p 74 (2023)
Industrial-sized fermenters differ from the laboratory environment in which bioprocess development initially took place. One of the issues that can lead to reduced productivity on a large scale or even early termination of the process is the presence
Externí odkaz:
https://doaj.org/article/7a8b26ac10a74a37819e734d28fde03c
Autor:
Suresh Sudarsan, Lars M. Blank, Alexander Dietrich, Oliver Vielhauer, Ralf Takors, Andreas Schmid, Matthias Reuss
Publikováno v:
Metabolic Engineering Communications, Vol 3, Iss , Pp 97-110 (2016)
Soil microorganisms mineralize lignin-derived aromatic carbon sources using oxidative catabolic pathways, such as the β-ketoadipate pathway. Although this aromatic pathway is one of the best-studied pathways in biochemistry, the complete pathway, in
Externí odkaz:
https://doaj.org/article/5c2d3bb657fa498c8cb056549e6f6818
Autor:
Mahsa Babaei, Kanchana Rueksomtawin Kildegaard, Aligholi Niaei, Maryam Hosseini, Sirous Ebrahimi, Suresh Sudarsan, Irini Angelidaki, Irina Borodina
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Oleaginous yeast Yarrowia lipolytica is a prospective host for production of succinic acid. The interruption of tricarboxylic acid cycle through succinate dehydrogenase gene (SDH) deletion was reported to result in strains incapable of glucose utiliz
Externí odkaz:
https://doaj.org/article/6eab9326be104d68b373812c5ac17fb9
Autor:
Larissa Ribeiro Ramos Tramontin, Kanchana Rueksomtawin Kildegaard, Suresh Sudarsan, Irina Borodina
Publikováno v:
Microorganisms, Vol 7, Iss 10, p 472 (2019)
Astaxanthin is a high-value red pigment and antioxidant used by pharmaceutical, cosmetics, and food industries. The astaxanthin produced chemically is costly and is not approved for human consumption due to the presence of by-products. The astaxanthi
Externí odkaz:
https://doaj.org/article/c440818c224140a099bd8b77d6edc4d5
Autor:
Alexander Rockenbach, Suresh Sudarsan, Judith Berens, Michael Kosubek, Jaroslav Lazar, Philipp Demling, René Hanke, Philip Mennicken, Birgitta E. Ebert, Lars M. Blank, Uwe Schnakenberg
Publikováno v:
Metabolites, Vol 9, Iss 10, p 211 (2019)
Exploring the dynamic behavior of cellular metabolism requires a standard laboratory method that guarantees rapid sampling and extraction of the cellular content. We propose a versatile sampling technique applicable to cells with different cell wall
Externí odkaz:
https://doaj.org/article/0b4b4cd17851483182bacda2c6ee085a
Autor:
Mohammad S. Radi, Jesus E. SalcedoSora, Se Hyeuk Kim, Suresh Sudarsan, Anand V. Sastry, Douglas B. Kell, Markus J. Herrgård, Adam M. Feist
Publikováno v:
Radi, M S, SalcedoSora, J E, Kim, S H, Sudarsan, S, Sastry, A V, Kell, D B, Herrgård, M J & Feist, A M 2022, ' Membrane transporter identification and modulation via adaptive laboratory evolution ', Metabolic Engineering, vol. 72, pp. 376-390 . https://doi.org/10.1016/j.ymben.2022.05.004
Membrane transport proteins are potential targets for medical and biotechnological applications. However, more than 30% of reported membrane transporter families are either poorly characterized or lack adequate functional annotation. Here, adaptive l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f51a77cd5245774aa82b9336e8974a4
https://pubmed.ncbi.nlm.nih.gov/35598887
https://pubmed.ncbi.nlm.nih.gov/35598887
Autor:
Suresh Sudarsan, Eko Roy Marella, Guokun Wang, Irina Borodina, Javier Sáez-Sáez, Marc Cernuda Pastor
Publikováno v:
Saez Saez, J, Wang, G, Marella, E R, Sudarsan, S, Cernuda Pastor, M & Borodina, I 2020, ' Engineering the oleaginous yeast Yarrowia lipolytica for high-level resveratrol production ', Metabolic Engineering, vol. 62, pp. 51-61 . https://doi.org/10.1016/j.ymben.2020.08.009
Metabolic Engineering
Metabolic Engineering
Resveratrol is a plant secondary metabolite with multiple health-beneficial properties. Microbial production of resveratrol in model microorganisms requires extensive engineering to reach commercially viable levels. Here, we explored the potential of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959a7dcde9e6016f69067b977f9fcd98
https://doi.org/10.1016/j.ymben.2020.08.009
https://doi.org/10.1016/j.ymben.2020.08.009
Autor:
Jie Zhang, Lea G. Hansen, Olga Gudich, Konrad Viehrig, Lærke M. M. Lassen, Lars Schrübbers, Khem B. Adhikari, Paulina Rubaszka, Elena Carrasquer-Alvarez, Ling Chen, Vasil D’Ambrosio, Beata Lehka, Ahmad K. Haidar, Saranya Nallapareddy, Konstantina Giannakou, Marcos Laloux, Dushica Arsovska, Marcus A. K. Jørgensen, Leanne Jade G. Chan, Mette Kristensen, Hanne B. Christensen, Suresh Sudarsan, Emily A. Stander, Edward Baidoo, Christopher J. Petzold, Tune Wulff, Sarah E. O’Connor, Vincent Courdavault, Michael K. Jensen, Jay D. Keasling
Publikováno v:
Nature
Zhang, J, Hansen, L G, Gudich, O, Viehrig, K, Lassen, L M M, Schrübbers, L, Adhikari, K B, Rubaszka, P, Carrasquer-Alvarez, E, Chen, L, D’Ambrosio, V, Lehka, B, Haidar, A K, Nallapareddy, S, Giannakou, K, Laloux, M, Arsovska, D, Jørgensen, M A K, Chan, L J G, Kristensen, M, Christensen, H B, Sudarsan, S, Stander, E A, Baidoo, E, Petzold, C J, Wulff, T, O’Connor, S E, Courdavault, V, Jensen, M K & Keasling, J D 2022, ' A microbial supply chain for production of the anti-cancer drug vinblastine ', Nature, vol. 609, no. 7926, pp. 341-347 . https://doi.org/10.1038/s41586-022-05157-3
Nature, vol 609, iss 7926
Zhang, J, Hansen, L G, Gudich, O, Viehrig, K, Lassen, L M M, Schrübbers, L, Adhikari, K B, Rubaszka, P, Carrasquer-Alvarez, E, Chen, L, D’Ambrosio, V, Lehka, B, Haidar, A K, Nallapareddy, S, Giannakou, K, Laloux, M, Arsovska, D, Jørgensen, M A K, Chan, L J G, Kristensen, M, Christensen, H B, Sudarsan, S, Stander, E A, Baidoo, E, Petzold, C J, Wulff, T, O’Connor, S E, Courdavault, V, Jensen, M K & Keasling, J D 2022, ' A microbial supply chain for production of the anti-cancer drug vinblastine ', Nature, vol. 609, no. 7926, pp. 341-347 . https://doi.org/10.1038/s41586-022-05157-3
Nature, vol 609, iss 7926
Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary metabolites with many medicinal properties, including the essential anti-cancer therapeutics vinblastine and vincristine1. As MIAs are difficult to chemically synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19bacac052957ae55ba7af120ea83ec4
https://pubmed.ncbi.nlm.nih.gov/36370691
https://pubmed.ncbi.nlm.nih.gov/36370691
Autor:
Michael Krogh Jensen, Morten Otto Alexander Sommer, Jay D. Keasling, Robert Mans, Jolanda ter Horst, Francesca Ambri, Roberto Di Blasi, Vasil D'ambrosio, Marcel van den Broek, Eleonora Dore, Peter Rugbjerg, Suresh Sudarsan
Publikováno v:
Metabolic Engineering, 61
D'ambrosio, V, Dore, E, Di Blasi, R, van den Broek, M, Sudarsan, S, ter Horst, J, Ambri, F, Sommer, M O A, Rugbjerg, P, Keasling, J D, Mans, R & Jensen, M K 2020, ' Regulatory control circuits for stabilizing long-term anabolic product formation in yeast ', Metabolic Engineering, vol. 61, pp. 369-380 . https://doi.org/10.1016/j.ymben.2020.07.006
Metabolic Engineering
D'ambrosio, V, Dore, E, Di Blasi, R, van den Broek, M, Sudarsan, S, ter Horst, J, Ambri, F, Sommer, M O A, Rugbjerg, P, Keasling, J D, Mans, R & Jensen, M K 2020, ' Regulatory control circuits for stabilizing long-term anabolic product formation in yeast ', Metabolic Engineering, vol. 61, pp. 369-380 . https://doi.org/10.1016/j.ymben.2020.07.006
Metabolic Engineering
Engineering living cells for production of chemicals, enzymes and therapeutics can burden cells due to use of limited native co-factor availability and/or expression burdens, totalling a fitness deficit compared to parental cells encoded through long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d97db74f5f9544ff063354d4e32b0d86
https://escholarship.org/uc/item/0cg460bm
https://escholarship.org/uc/item/0cg460bm
Autor:
Maryam Hosseini, Kanchana Rueksomtawin Kildegaard, Aligholi Niaei, Irini Angelidaki, Irina Borodina, Suresh Sudarsan, Mahsa Babaei, Sirous Ebrahimi
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 7 (2019)
Babaei, M, Kildegaard, K R, Niaei, A, Hosseini, M, Ebrahimi, S, Sudarsan, S, Angelidaki, I & Borodina, I 2019, ' Engineering Oleaginous Yeast as the Host for Fermentative Succinic Acid Production From Glucose ', Frontiers in Bioengineering and Biotechnology, vol. 7, 361 . https://doi.org/10.3389/fbioe.2019.00361
Frontiers in Bioengineering and Biotechnology
Babaei, M, Kildegaard, K R, Niaei, A, Hosseini, M, Ebrahimi, S, Sudarsan, S, Angelidaki, I & Borodina, I 2019, ' Engineering Oleaginous Yeast as the Host for Fermentative Succinic Acid Production From Glucose ', Frontiers in Bioengineering and Biotechnology, vol. 7, 361 . https://doi.org/10.3389/fbioe.2019.00361
Frontiers in Bioengineering and Biotechnology
Oleaginous yeast Yarrowia lipolytica is a prospective host for production of succinic acid. The interruption of tricarboxylic acid cycle through succinate dehydrogenase gene (SDH) deletion was reported to result in strains incapable of glucose utiliz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83448a9d5a0758ef824630e6adff8208
https://doi.org/10.3389/fbioe.2019.00361
https://doi.org/10.3389/fbioe.2019.00361