Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Surendra R. Punganuru"'
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 4, Pp 305-323 (2018)
Whether the antimutagenic DNA repair protein MGMT works solo in human cells and if it has other cellular functions is not known. Here, we show that human MGMT associates with PCNA and in turn, with the cell cycle inhibitor, p21cip1 in glioblastoma an
Externí odkaz:
https://doaj.org/article/188c8ca4ac824ea7b6c4851b2b0de682
Autor:
Surendra R. Punganuru, Viswanath Arutla, Wei Zhao, Mehrdad Rajaei, Hemantkumar Deokar, Ruiwen Zhang, John K. Buolamwini, Kalkunte S. Srivenugopal, Wei Wang
Publikováno v:
Cells, Vol 9, Iss 7, p 1592 (2020)
There is a desperate need for novel and efficacious chemotherapeutic strategies for human brain cancers. There are abundant molecular alterations along the p53 and MDM2 pathways in human glioma, which play critical roles in drug resistance. The prese
Externí odkaz:
https://doaj.org/article/0aba6ac868e54a4a99c45cc966adebbf
Publikováno v:
Cancer Research. 83:457-457
NAD(P)H-quinone oxidoreductase 1 (NQO1) is a rational target for designing tumor-selective anticancer therapies because the 2-electron reductase is expressed at very low levels in normal tissues but present abundantly (5 to 200-fold) in human cancers
Autor:
Evanna L. Mills, Benjamin A. Olenchock, Edward T. Chouchani, Surendra R. Punganuru, Wen Zhou, Yan Liu, Ana M. Metelo, Michelle L. Kelley, Andrew M. Intlekofer, Iiro Taneli Helenius, Yiyun Zhang, Othon Iliopoulos, Eugene P. Rhee, Jing-Ruey J. Yeh, Hanumantha Rao Madala, Kyung Bo Kim
Publikováno v:
Cancer Res
Under conditions of inherent or induced mitochondrial dysfunction, cancer cells manifest overlapping metabolic phenotypes, suggesting that they may be targeted via a common approach. Here, we use multiple oxidative phosphorylation (OXPHOS)–competen
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 4, Pp 305-323 (2018)
Whether the antimutagenic DNA repair protein MGMT works solo in human cells and if it has other cellular functions is not known. Here, we show that human MGMT associates with PCNA and in turn, with the cell cycle inhibitor, p21cip1 in glioblastoma an
Autor:
Surendra R. Punganuru, Francis Ali-Osman, Hanumantha Rao Madala, Kalkunte S. Srivenugopal, Ruiwen Zhang
Publikováno v:
Oncotarget
There is great interest in repurposing disulfiram (DSF), a rapidly metabolizing nontoxic drug, for brain cancers and other cancers. To overcome the instability and low therapeutic efficacy, we engineered passively-targeted DSF-nanoparticles (DSFNPs)
Autor:
Surendra R. Punganuru, Viswanath Arutla, Kalkunte S. Srivenugopal, Ruiwen Zhang, Hanumantha Rao Madala
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports
Scientific Reports
The Near-infrared Fluorescence (NIRF) molecular imaging of cancer is known to be superior in sensitivity, deeper penetration, and low phototoxicity compared to other imaging modalities. In view of an increased need for efficient and targeted imaging
Publikováno v:
Drug Research. 67:25-31
In this paper a simple and efficient method for the unsymmetrical terphenyls via sequential one-pot Suzuki coupling reactions using Pd(OAc)2 without isolation of the intermediate is described. The prepared terphenyls were found to possess potent anti
Autor:
Debasish Basak, George C. Bobustuc, A.G.M. Mostofa, Mohd Aslam Yusuf, Hanumantha Rao Madala, Kalkunte S. Srivenugopal, Nathan I. Bailey, Ameya Paranjpe, Surendra R. Punganuru, Santhi D. Konduri, Francis Ali-Osman
Publikováno v:
Journal of Biomedical Research
Endocrine therapy using estrogen receptor-α (ER-α) antagonists for attenuating horm2one-driven cell proliferation is a major treatment modality for breast cancers. To exploit any DNA repair deficiencies associated with endocrine therapy, we investi
Publikováno v:
Journal of Chemical Research. 40:375-378
A concise stereoselective total synthesis of (+)-monocerin has been accomplished using cross metathesis, tandem dihydroxylation-SN2 cyclisation and intramolecular alkoxycarbonylation as key steps. Cross-metathesis of 2-iodo-3,4,5-trimethoxyvinylbenze