Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Surendra J. Chavan"'
Publikováno v:
Archives of Biochemistry and Biophysics. 324:143-152
Oltipraz (5-pyrazinyl-4-methyl-1,2-dithiole-3-thione), which is undergoing clinical evaluation as an anticarcinogen, also inhibits HIV-1 replication (IC50 approximately equal to 10 microM). The inactivation of RT appears to be a relevant antiviral me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28f5f4f2c7fff20d24b43bb46eb587e
https://doi.org/10.1006/abbi.1995.9916
https://doi.org/10.1006/abbi.1995.9916
Publikováno v:
Biochemical and biophysical research communications. 221(3)
Metabolite III (MIII, 7-methyl-6,8-bis(methylthio)pyrrolo[1,2-alpha]pyrazine), a major in vivo metabolite of oltipraz (OLT, 5-pyrazinyl-4-methyl-1,2-dithiole-3-thione), appears to disrupt human immunodeficiency virus type 1 (HIV-1) replication at a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a44c97d41090fe85502494047b356a
https://pubmed.ncbi.nlm.nih.gov/8629998
https://pubmed.ncbi.nlm.nih.gov/8629998
Publikováno v:
Journal of cellular biochemistry. Supplement. 22
Glutathione (GSH) levels are markedly depleted in patients infected with human immunodeficiency virus type 1 (HIV-1) and supplementation of media with high concentrations (5-20 mM) of low-molecular weight thiols prevents HIV-1 replication in cultured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b0f628d376d9a5971ff16628b09541
https://pubmed.ncbi.nlm.nih.gov/8538188
https://pubmed.ncbi.nlm.nih.gov/8538188