Zobrazeno 1 - 10
of 235
pro vyhledávání: '"Suren M. Zakian"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8695 (2024)
Hypertrophic cardiomyopathy (HCM) is a cardiovascular pathology that is caused by variants in genes encoding sarcomere-associated proteins. However, the clinical significance of numerous variants in HCM-associated genes is still unknown. CRISPR/Cas9
Externí odkaz:
https://doaj.org/article/c47c5e71b5be4defb58777b4c7d7618f
Autor:
Elena V. Grigor’eva, Lana V. Karapetyan, Anastasia A. Malakhova, Sergey P. Medvedev, Julia M. Minina, Varduhi H. Hayrapetyan, Valentina S. Vardanyan, Suren M. Zakian, Arsen Arakelyan, Roksana Zakharyan
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6102 (2024)
Familial Mediterranean fever (FMF) is a systemic autoinflammatory disorder caused by inherited mutations in the MEFV (Mediterranean FeVer) gene, located on chromosome 16 (16p13.3) and encoding the pyrin protein. Despite the existing data on MEFV muta
Externí odkaz:
https://doaj.org/article/eb271f669bc4489d83c6cf63cf08053d
Autor:
Elena S. Yarkova, Elena V. Grigor’eva, Sergey P. Medvedev, Denis A. Tarasevich, Sophia V. Pavlova, Kamila R. Valetdinova, Julia M. Minina, Suren M. Zakian, Anastasia A. Malakhova
Publikováno v:
Biomedicines, Vol 12, Iss 4, p 744 (2024)
Endoplasmic reticulum (ER) stress is involved in the pathogenesis of many human diseases, such as cancer, type 2 diabetes, kidney disease, atherosclerosis and neurodegenerative diseases, in particular Parkinson’s disease (PD). Since there is curren
Externí odkaz:
https://doaj.org/article/40ac1f132b0c46d1bfe312659914ee7f
Autor:
Elena V. Grigor’eva, Anastasia A. Malakhova, Lilit Ghukasyan, Varduhi Hayrapetyan, Sofi Atshemyan, Valentina Vardanyan, Suren M. Zakian, Roksana Zakharyan, Arsen Arakelyan
Publikováno v:
Stem Cell Research, Vol 71, Iss , Pp 103147- (2023)
The study of pathological processes in cells carrying mutations should be carried out in comparison with a healthy control group. Familial Mediterranean fever (FMF), which is caused by a mutation in the MEFV gene, is predominantly found in people of
Externí odkaz:
https://doaj.org/article/caca0b4698b54c53bf36c3d4e0f1fe3b
Autor:
Svetlana N. Khodyreva, Ekaterina S. Ilina, Nadezhda S. Dyrkheeva, Alina S. Kochetkova, Alexandra A. Yamskikh, Ekaterina A. Maltseva, Anastasia A. Malakhova, Sergey P. Medvedev, Suren M. Zakian, Olga I. Lavrik
Publikováno v:
Cells, Vol 13, Iss 4, p 302 (2024)
Base excision repair (BER) is the predominant pathway for the removal of most forms of hydrolytic, oxidative, and alkylative DNA lesions. The precise functioning of BER is achieved via the regulation of each step by regulatory/accessory proteins, wit
Externí odkaz:
https://doaj.org/article/0983d4f52fdc49359c9bed4462992ed4
Autor:
Irina S. Zakharova, Alexander I. Shevchenko, Mhd Amin Arssan, Aleksei A. Sleptcov, Maria S. Nazarenko, Aleksei A. Zarubin, Nina V. Zheltysheva, Vlada A. Shevchenko, Narek A. Tmoyan, Shoraan B. Saaya, Marat V. Ezhov, Valery V. Kukharchuk, Yelena V. Parfyonova, Suren M. Zakian
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 2, p 689 (2024)
Defects in the low-density lipoprotein receptor (LDLR) are associated with familial hypercholesterolemia (FH), manifested by atherosclerosis and cardiovascular disease. LDLR deficiency in hepatocytes leads to elevated blood cholesterol levels, which
Externí odkaz:
https://doaj.org/article/1a367c718be94a42babd8f91bc18a80c
Autor:
Elena S. Yarkova, Elena V. Grigor’eva, Sergey P. Medvedev, Sophia V. Pavlova, Suren M. Zakian, Anastasia A. Malakhova
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 327 (2023)
Parkinson’s disease (PD) is a neurodegenerative disorder that ranks second in prevalence after Alzheimer’s disease. The number of PD diagnoses increases annually. Nevertheless, modern PD treatments merely mitigate symptoms rather than preventing
Externí odkaz:
https://doaj.org/article/4e47ad45cc044c648b1e5408ea4481b5
Autor:
Elizaveta Ustyantseva, Sophia V. Pavlova, Anastasia A. Malakhova, Kirill Ustyantsev, Suren M. Zakian, Sergey P. Medvedev
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Oxidative stress plays an important role in the development of neurodegenerative diseases, being either the initiator or part of a pathological cascade that leads to the neuron’s death. Genetically encoded biosensors of oxidative stress de
Externí odkaz:
https://doaj.org/article/5953b08d365647b29b35b70e9005d51f
Autor:
Vladlena S. Makeeva, Nadezhda S. Dyrkheeva, Olga I. Lavrik, Suren M. Zakian, Anastasia A. Malakhova
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16798 (2023)
The spectrum of neurodegenerative diseases known today is quite extensive. The complexities of their research and treatment lie not only in their diversity. Even many years of struggle and narrowly focused research on common pathologies such as Alzhe
Externí odkaz:
https://doaj.org/article/9740d251b11c4c239da7b21ba7acccd9
Autor:
Elena V. Grigor'eva, Anastasia A. Malakhova, Diana A. Sorogina, Sofia V. Pavlova, Tuyana B. Malankhanova, Natalia Yu. Abramycheva, Sergey A. Klyushnikov, Sergey N. Illarioshkin, Suren M. Zakian
Publikováno v:
Stem Cell Research, Vol 63, Iss , Pp 102868- (2022)
Huntington's disease (HD) is a hereditary autosomal dominant neurodegenerative disease caused by the polyglutamine stretch expansion in the huntingtin (HTT) protein. In HD, dysregulation of multiple cellular processes occurs, resulting in the death o
Externí odkaz:
https://doaj.org/article/9857262fec844cbd82b18c42cd467eba