Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Suren M Zakian"'
Autor:
Daria V Kim, Liliya M Kulishova, Natalia A Torgasheva, Vasily S Melentyev, Grigory L Dianov, Sergey P Medvedev, Suren M Zakian, Dmitry O Zharkov
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257473 (2021)
The major human apurinic/apyrimidinic (AP) site endonuclease, APEX1, is a central player in the base excision DNA repair (BER) pathway and has a role in the regulation of DNA binding by transcription factors. In vertebrates, APEX1 knockouts are embry
Externí odkaz:
https://doaj.org/article/757a8e4689914b249024796456717b11
Autor:
Ksenia N Morozova, Lyubov A Suldina, Tuyana B Malankhanova, Elena V Grigor'eva, Suren M Zakian, Elena Kiseleva, Anastasia A Malakhova
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0204735 (2018)
Modeling of neurodegenerative diseases in vitro holds great promise for biomedical research. Human cell lines harboring a mutations in disease-causing genes are thought to recapitulate early stages of the development an inherited disease. Modern geno
Externí odkaz:
https://doaj.org/article/17ccde2e1369434f962ba49b85febfec
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128497 (2015)
DNA replication initiates at specific positions termed replication origins. Genome-wide studies of human replication origins have shown that origins are organized into replication initiation zones. However, only few replication initiation zones have
Externí odkaz:
https://doaj.org/article/fe96f3ef215849c196f82dadfec086f1
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0132084 (2015)
Externí odkaz:
https://doaj.org/article/371033f6b682437bb3cd6035b07a024d
Autor:
Evgeniya A Vaskova, Elena V Dementyeva, Alexander I Shevchenko, Sophia V Pavlova, Elena V Grigor'eva, Antonina I Zhelezova, John L Vandeberg, Suren M Zakian
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88256 (2014)
In rodent female mammals, there are two forms of X-inactivation - imprinted and random which take place in extraembryonic and embryonic tissues, respectively. The inactive X-chromosome during random X-inactivation was shown to contain two types of fa
Externí odkaz:
https://doaj.org/article/c9317183ee0b474e83fefd37577ab49c
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8695 (2024)
Hypertrophic cardiomyopathy (HCM) is a cardiovascular pathology that is caused by variants in genes encoding sarcomere-associated proteins. However, the clinical significance of numerous variants in HCM-associated genes is still unknown. CRISPR/Cas9
Externí odkaz:
https://doaj.org/article/c47c5e71b5be4defb58777b4c7d7618f
Autor:
Konstantin E Orishchenko, Sophia V Pavlova, Eugeny A Elisaphenko, Vladimir V Sherstyuk, Alexander V Prinz, Alexander I Shevchenko, Elena V Dementyeva, Suren M Zakian
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e33994 (2012)
X chromosome inactivation takes place in the early development of female mammals and depends on the Xist gene expression. The mechanisms of Xist expression regulation have not been well understood so far. In this work, we compared Xist promoter regio
Externí odkaz:
https://doaj.org/article/eadfe504a8364ec38189762fb1907308
Autor:
Alexander I Shevchenko, Anastasia A Malakhova, Eugeny A Elisaphenko, Nina A Mazurok, Tatyana B Nesterova, Neil Brockdorff, Suren M Zakian
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e22771 (2011)
One of the two X chromosomes in female mammalian cells is subject to inactivation (XCI) initiated by the Xist gene. In this study, we examined in rodents (voles and rat) the conservation of the microsatellite region DXPas34, the Tsix gene (antisense
Externí odkaz:
https://doaj.org/article/be1696b8bc604ade82841535688d6a19
Autor:
Elena V Grigor'eva, Alexander I Shevchenko, Nina A Mazurok, Eugeny A Elisaphenko, Antonina I Zhelezova, Alexander G Shilov, Pavel A Dyban, Andrey P Dyban, Ekaterina M Noniashvili, Sergey Ya Slobodyanyuk, Tatyana B Nesterova, Neil Brockdorff, Suren M Zakian
Publikováno v:
PLoS ONE, Vol 4, Iss 9, p e7161 (2009)
The derivation of stable multipotent trophoblast stem (TS) cell lines from preimplantation, and early postimplantation mouse embryos has been reported previously. FGF4, and its receptor FGFR2, have been identified as embryonic signaling factors respo
Externí odkaz:
https://doaj.org/article/1ac93b650cf44cbca3927376a27ed73e
Autor:
Eugeny A Elisaphenko, Nikolay N Kolesnikov, Alexander I Shevchenko, Igor B Rogozin, Tatyana B Nesterova, Neil Brockdorff, Suren M Zakian
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2521 (2008)
X-chromosome inactivation, which occurs in female eutherian mammals is controlled by a complex X-linked locus termed the X-inactivation center (XIC). Previously it was proposed that genes of the XIC evolved, at least in part, as a result of pseudogen
Externí odkaz:
https://doaj.org/article/2a5d03587e944e00b91b0c1f9f5f481f