Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Surekha Neelisetty"'
Autor:
Wei Shi, Timothy M. Sullivan, Jeff Reese, Katharina Hopp, Christa Gaskill, Dwight J. Klemm, Stellor Nlandu Khodo, Kevin C. Ess, Julie W. Harral, Leslie Gewin, Megan E. Summers, Surekha Neelisetty, Valentina Kon, Susan M. Majka
Publikováno v:
American Journal of Physiology-Renal Physiology. 317:F1201-F1210
Tuberous sclerosis complex 2 (TSC2), or tuberin, is a pivotal regulator of the mechanistic target of rapamycin signaling pathway that controls cell survival, proliferation, growth, and migration. Loss of Tsc2 function manifests in organ-specific cons
Autor:
Kenyi Saito-Diaz, Ethan Lee, Tessa Huffstater, Robert S. McMahon, Balakuntalam S. Kasinath, Surekha Neelisetty, Yosuke Osaki, Alla V. Ivanova, Makoto Mark Taketo, Jane Tonello, Raymond C. Harris, Lauren Scarfe, Stellor Nlandu-Khodo, Mark P. deCaestecker, Melanie Phillips-Mignemi, Haichun Yang, Leslie Gewin
Publikováno v:
JCI Insight
The Wnt/β-catenin signaling pathway plays an important role in renal development and is reexpressed in the injured kidney and other organs. β-Catenin signaling is protective in acute kidney injury (AKI) through actions on the proximal tubule, but t
Autor:
Peter E. Clark, Surekha Neelisetty, Agnes B. Fogo, Marika Manolopoulou, Haichun Yang, Melanie Phillips, Ethan Lee, Raymond C. Harris, Leslie Gewin, Gautam Bhave, Lauren May, Makoto Mark Taketo, Stellor Nlandu-Khodo
Publikováno v:
Journal of the American Society of Nephrology. 28:3490-3503
The TGF-β and Wnt/β-catenin pathways have important roles in modulating CKD, but how these growth factors affect the epithelial response to CKD is not well studied. TGF-β has strong profibrotic effects, but this pleiotropic factor has many differe
Autor:
Leslie S, Gewin, Megan E, Summers, Julie W, Harral, Christa F, Gaskill, Stellor Nlandu, Khodo, Surekha, Neelisetty, Timothy M, Sullivan, Katharina, Hopp, J Jeffrey, Reese, Dwight J, Klemm, Valentina, Kon, Kevin C, Ess, Wei, Shi, Susan M, Majka
Publikováno v:
Am J Physiol Renal Physiol
Tuberous sclerosis complex 2 (TSC2), or tuberin, is a pivotal regulator of the mechanistic target of rapamycin signaling pathway that controls cell survival, proliferation, growth, and migration. Loss of Tsc2 function manifests in organ-specific cons
Autor:
Luke G. Woodbury, Raymond C. Harris, Surekha Neelisetty, Leslie Gewin, Stellor Nlandu Khodo, Elizabeth Green, Roy Zent
Publikováno v:
American Journal of Physiology-Renal Physiology. 310:F499-F510
Transforming growth factor-β (TGF-β) and hepatocyte growth factor (HGF) play key roles in regulating the response to renal injury but are thought to mediate divergent effects on cell behavior. However, how TGF-β signaling alters the response to HG
Autor:
Luke G. Woodbury, Surekha Neelisetty, Raymond C. Harris, Stellor Nlandu-Khodo, Haichun Yang, Agnes B. Fogo, Karen Reynolds, Leslie Gewin, Catherine E. Alford, Roy Zent, Chuanming Hao
Publikováno v:
Kidney international
Transforming growth factor-β (TGF-β) strongly promotes renal tubulointerstitial fibrosis, but the cellular target that mediates its profibrotic actions has not been clearly identified. While in vitro data suggest that TGF-β-induced matrix producti
Autor:
Sangeetha Vadivelu, Surekha Neelisetty, Raymond C. Harris, Manakan B. Srichai, Ambra Pozzi, Paisit Paueksakon, Leslie Gewin, Roy Zent
TGF-β is a profibrotic growth factor in CKD, but its role in modulating the kidney's response to AKI is not well understood. The proximal tubule epithelial cell, which is the main cellular target of AKI, expresses high levels of both TGF-β and its
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c156fb6d0cc3397999ab2a89ad30f62
https://europepmc.org/articles/PMC3507360/
https://europepmc.org/articles/PMC3507360/