Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Surbhi Joshi"'
Autor:
Frank J. Rauscher, Joseph R. Testa, Eileen J. Kennedy, Joseph Salvino, Anne M. Bowcock, J. William Harbour, S. Bruce Malkowicz, David Hinds, Kasirajan Ayyanathan, Jacob P. Mandell, Surbhi Joshi, Alexander Polo, Paul R. Collop, Mitchell Cheung, Eleonora Sementino, Jeremy W. Prokop, Daniel S. McCracken, Joel Cassel, Hongzhuang Peng
S2. ASXL structure and evolution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbaae5bece1e861668ab75b86be99103
https://doi.org/10.1158/1541-7786.22517014.v1
https://doi.org/10.1158/1541-7786.22517014.v1
Autor:
Frank J. Rauscher, Joseph R. Testa, Eileen J. Kennedy, Joseph Salvino, Anne M. Bowcock, J. William Harbour, S. Bruce Malkowicz, David Hinds, Kasirajan Ayyanathan, Jacob P. Mandell, Surbhi Joshi, Alexander Polo, Paul R. Collop, Mitchell Cheung, Eleonora Sementino, Jeremy W. Prokop, Daniel S. McCracken, Joel Cassel, Hongzhuang Peng
S3. Domain architecture of human BAP1 and ASXL2 and the proteins/domains used in this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e72632654f3c1b053e0452836939010
https://doi.org/10.1158/1541-7786.22517011.v1
https://doi.org/10.1158/1541-7786.22517011.v1
Autor:
Frank J. Rauscher, Joseph R. Testa, Eileen J. Kennedy, Joseph Salvino, Anne M. Bowcock, J. William Harbour, S. Bruce Malkowicz, David Hinds, Kasirajan Ayyanathan, Jacob P. Mandell, Surbhi Joshi, Alexander Polo, Paul R. Collop, Mitchell Cheung, Eleonora Sementino, Jeremy W. Prokop, Daniel S. McCracken, Joel Cassel, Hongzhuang Peng
S4. Refinement of the mechanism for ASXL stimulation of BAP deubiquitinase activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b51595e3a9234c24b038d8c8d0f7b5b
https://doi.org/10.1158/1541-7786.22517008.v1
https://doi.org/10.1158/1541-7786.22517008.v1
Autor:
Frank J. Rauscher, Joseph R. Testa, Eileen J. Kennedy, Joseph Salvino, Anne M. Bowcock, J. William Harbour, S. Bruce Malkowicz, David Hinds, Kasirajan Ayyanathan, Jacob P. Mandell, Surbhi Joshi, Alexander Polo, Paul R. Collop, Mitchell Cheung, Eleonora Sementino, Jeremy W. Prokop, Daniel S. McCracken, Joel Cassel, Hongzhuang Peng
S1. BAP1 expression in mouse single cell datasets.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f353291c61598a2d34be8eeb79d83867
https://doi.org/10.1158/1541-7786.22517017.v1
https://doi.org/10.1158/1541-7786.22517017.v1
Publikováno v:
Brain Structure and Function. 226:2357-2373
The prefrontal cortex (PFC) governs top-down control of attention and is known to be vulnerable in aging. Cortical reorganization with increased PFC recruitment is suggested to account for functional compensation. Here, we hypothesized that reduced P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582567244898d4ba0225c60020d0594b
https://doi.org/10.1007/s00429-021-02336-2
https://doi.org/10.1007/s00429-021-02336-2
Publikováno v:
Neurobiol Aging
Cortical remodeling is linked to age-related cognitive changes in humans; however, the mechanisms underlying cortical reorganization in aging remain unknown. Here we examined the consequences of mild cholinergic thinning of the prefrontal cortex (PFC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e1e7c5fe8365d4c2fd58d53a302c5d
https://europepmc.org/articles/PMC8338743/
https://europepmc.org/articles/PMC8338743/
Autor:
David A. Hinds, Jeremy W. Prokop, Kasirajan Ayyanathan, Joel Cassel, Frank J. Rauscher, S. Bruce Malkowicz, Daniel S. McCracken, Jacob P. Mandell, Surbhi Joshi, Joseph M. Salvino, Alexander Polo, Joseph R. Testa, Hongzhuang Peng, J. William Harbour, Anne M. Bowcock, Eileen J. Kennedy, Paul R. Collop
BAP1 is a ubiquitin hydrolase whose deubiquitinase activity is mediated by polycomb group-like protein ASXL2. Cancer-related mutations/deletions of BAP1 lead to loss-of-function either by directly targeting the catalytic (UCH) or ULD domains of BAP1,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b47174b8ea6bec33d9762293fa3baea
https://doi.org/10.1101/2020.02.24.962464
https://doi.org/10.1101/2020.02.24.962464
Autor:
Kasirajan Ayyanathan, Eleonora Sementino, Joel Cassel, Frank J. Rauscher, Mitchell Cheung, S. Bruce Malkowicz, Alexander Polo, Jeremy W. Prokop, Anne M. Bowcock, Paul R. Collop, Hongzhuang Peng, Surbhi Joshi, David A. Hinds, Eileen J. Kennedy, Daniel S. McCracken, Joseph M. Salvino, J. William Harbour, Jacob P. Mandell, Joseph R. Testa
Publikováno v:
Mol Cancer Res
BAP1 is an ubiquitin hydrolase whose deubiquitinase activity is mediated by polycomb group-like protein ASXL2. Cancer-related BAP1 mutations/deletions lead to loss-of-function by targeting the catalytic ubiquitin C-terminal hydrolase (UCH) or UCH37-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f308b3266d3eb989c4bd32c85465e0c
https://pubmed.ncbi.nlm.nih.gov/33731362
https://pubmed.ncbi.nlm.nih.gov/33731362
Autor:
Surbhi Joshi, Eric A. Ross, Vinay Parikh, Mathieu E. Wimmer, Michael Slifker, Yin-Fei Tan, Michael R. Duggan
Publikováno v:
Neurobiol Learn Mem
Although changes in cognitive functions including attention are well documented in aging, the neurobiological basis for such alterations is not fully understood. Increasing evidence points towards the contribution of genetic factors in age-related co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a859a9f94289b50be68282b62d5b481
https://pubmed.ncbi.nlm.nih.gov/31185277
https://pubmed.ncbi.nlm.nih.gov/31185277
Publikováno v:
The New Zealand medical journal. 118(1218)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::01fe706f9b42e7c59220b28879e091af
https://pubmed.ncbi.nlm.nih.gov/16027744
https://pubmed.ncbi.nlm.nih.gov/16027744