On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity.

Autor: Edgar RCS; School of Medicine, Deakin University, Geelong, Australia.; The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia., Malcolm TR; Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia., Siddiqui G; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia., Giannangelo C; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia., Counihan NA; School of Medicine, Deakin University, Geelong, Australia.; The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia., Challis M; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia., Duffy S; Discovery Biology, Centre for Cellular Phenomics, Griffith University, Nathan, Queensland, Australia., Chowdhury M; School of Medicine, Deakin University, Geelong, Australia.; The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia., Marfurt J; Global Health and Tropical Medicine Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia., Dans M; School of Medicine, Deakin University, Geelong, Australia.; The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia., Wirjanata G; Global Health and Tropical Medicine Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia., Noviyanti R; Eijkman Institute for Molecular Biology, Jakarta, Indonesia., Daware K; Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia., Suraweera CD; Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia., Price RN; Global Health and Tropical Medicine Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand., Wittlin S; Swiss Tropical and Public Health Institute, Allschwil, Switzerland.; University of Basel, Basel, Switzerland., Avery VM; School of Environment and Science, Griffith Sciences, Griffith University, Nathan, Queensland, Australia., Drinkwater N; Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia., Charman SA; Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia., Creek DJ; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia., de Koning-Ward TF; School of Medicine, Deakin University, Geelong, Australia.; The Institute for Mental and Physical Health and Clinical Translation, Deakin University, Geelong, Australia., Scammells PJ; Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia., McGowan S; Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Australia.

Publikováno v: MBio [mBio] 2024 Jun 12; Vol. 15 (6), pp. e0096624. Date of Electronic Publication: 2024 May 08.

Crystal Structures of Epstein-Barr Virus Bcl-2 Homolog BHRF1 Bound to Bid and Puma BH3 Motif Peptides.

Autor: Suraweera CD; Department of Biochemistry & Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia., Hinds MG; Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3010, Australia., Kvansakul M; Department of Biochemistry & Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.

Publikováno v: Viruses [Viruses] 2022 Oct 09; Vol. 14 (10). Date of Electronic Publication: 2022 Oct 09.

Metazoans and Intrinsic Apoptosis: An Evolutionary Analysis of the Bcl-2 Family.

Autor: Suraweera CD; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC 3086, Australia., Banjara S; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC 3086, Australia., Hinds MG; Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3052, Australia., Kvansakul M; Department of Biochemistry and Chemistry, La Trobe Institute for Molecular Science, La Trobe University, Bundoora, VIC 3086, Australia.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2022 Mar 28; Vol. 23 (7). Date of Electronic Publication: 2022 Mar 28.

Poxviral Strategies to Overcome Host Cell Apoptosis.

Autor: Suraweera CD; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia., Hinds MG; Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, VIC 3052, Australia., Kvansakul M; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.

Publikováno v: Pathogens (Basel, Switzerland) [Pathogens] 2020 Dec 23; Vol. 10 (1). Date of Electronic Publication: 2020 Dec 23.

Structural insight into tanapoxvirus-mediated inhibition of apoptosis.

Autor: Suraweera CD; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia., Anasir MI; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia., Chugh S; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia., Javorsky A; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia., Impey RE; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia., Hasan Zadeh M; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia., Soares da Costa TP; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia., Hinds MG; Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Australia., Kvansakul M; Department of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Australia.

Publikováno v: The FEBS journal [FEBS J] 2020 Sep; Vol. 287 (17), pp. 3733-3750. Date of Electronic Publication: 2020 May 31.