Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia.

Autor: Jin Q; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Gutierrez Diaz B; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Pieters T; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Center for Medical Genetics, Ghent University and University Hospital, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Zhou Y; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Narang S; Department of Pathology, New York University School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY, USA.; Applied Bioinformatics Laboratories, Office of Science and Research, New York University School of Medicine, New York, NY, USA., Fijalkwoski I; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Center for Medical Genetics, Ghent University and University Hospital, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Borin C; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Center for Medical Genetics, Ghent University and University Hospital, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Van Laere J; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Center for Medical Genetics, Ghent University and University Hospital, Ghent, Belgium., Payton M; Division of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Cho BK; Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA., Han C; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Sun L; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Serafin V; Oncohematology Laboratory, Department of Women's and Children's Health, University of Padova, Padova, Italy.; Department of Surgery Oncology and Gastroenterology, Oncology and Immunology Section, University of Padova, Padova, Italy., Yacu G; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA., Von Loocke W; Department of Pathology, New York University School of Medicine, New York, NY, USA., Basso G; Oncohematology Laboratory, Department of Women's and Children's Health, University of Padova, Padova, Italy.; Department of Surgery Oncology and Gastroenterology, Oncology and Immunology Section, University of Padova, Padova, Italy., Veltri G; Oncohematology Laboratory, Department of Women's and Children's Health, University of Padova, Padova, Italy., Dreveny I; School of Pharmacy, University of Nottingham, Nottingham NG7 2RD, UK., Ben-Sahra I; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Goo YA; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.; Simpson Querrey Center for Epigenetics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.; Proteomics Center of Excellence, Northwestern University, Evanston, IL, USA., Safgren SL; Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Tsai YC; University Children's Hospital, Division of Pediatric Oncology, University of Zurich, Zurich, Switzerland., Bornhauser B; University Children's Hospital, Division of Pediatric Oncology, University of Zurich, Zurich, Switzerland., Suraneni PK; Department of Cell and Developmental Biology, Northwestern University, Chicago, IL, USA., Gaspar-Maia A; Division of Experimental Pathology and Laboratory Medicine, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA., Kandela I; Center for Developmental Therapeutics, Northwestern University, Evanston, IL, USA., Van Vlierberghe P; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Center for Medical Genetics, Ghent University and University Hospital, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium., Crispino JD; Division of Experimental Hematology, St. Jude Children's Research Hospital, Memphis, TN, USA., Tsirigos A; Department of Pathology, New York University School of Medicine, New York, NY, USA.; Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY, USA.; Applied Bioinformatics Laboratories, Office of Science and Research, New York University School of Medicine, New York, NY, USA., Ntziachristos P; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.; Center for Medical Genetics, Ghent University and University Hospital, Ghent, Belgium.; Cancer Research Institute Ghent (CRIG), Ghent, Belgium.

Publikováno v: Science advances [Sci Adv] 2022 Dec 09; Vol. 8 (49), pp. eabq8437. Date of Electronic Publication: 2022 Dec 09.

Dynamins 2 and 3 control the migration of human megakaryocytes by regulating CXCR4 surface expression and ITGB1 activity.

Autor: Suraneni PK; Department of Medicine and., Corey SJ; Department of Pediatrics, Northwestern University School of Medicine, Chicago, IL.; Department of Pediatrics.; Department of Microbiology/Immunology, and.; Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA., Hession MJ; Department of Pediatrics, Northwestern University School of Medicine, Chicago, IL., Ishaq R; Unité mixte de recherche (UMR) 1170, INSERM, Equipe labellisée, Ligue Nationale contre le Cancer, Villejuif, France.; UMR 1170, INSERM, Université Paris-Saclay, Villejuif, France.; UMR 1170, INSERM, Institut Gustave Roussy, Villejuif, France.; Institut Universitaire, Hématologie, Université Paris 7 Diderot, Paris, France., Awomolo A; Department of Pediatrics, Northwestern University School of Medicine, Chicago, IL., Hasan S; Department of Medicine and., Shah C; Department of Medicine and.; MilliporeSigma, Burlington, MA; and., Liu H; Department of Medicine, University of Chicago, Chicago, IL., Wickrema A; Department of Medicine, University of Chicago, Chicago, IL., Debili N; Unité mixte de recherche (UMR) 1170, INSERM, Equipe labellisée, Ligue Nationale contre le Cancer, Villejuif, France.; UMR 1170, INSERM, Université Paris-Saclay, Villejuif, France.; UMR 1170, INSERM, Institut Gustave Roussy, Villejuif, France., Crispino JD; Department of Medicine and., Eklund EA; Department of Medicine and., Chen Y; Department of Medicine and.; Department of Pediatrics, Northwestern University School of Medicine, Chicago, IL.

Publikováno v: Blood advances [Blood Adv] 2018 Dec 11; Vol. 2 (23), pp. 3540-3552.

Novel function of FAXDC2 in megakaryopoiesis.

Autor: Jin Q; College of Life Sciences, Wuhan University, Wuhan, Hubei, People's Republic of China.; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Ren Y; College of Life Sciences, Wuhan University, Wuhan, Hubei, People's Republic of China., Wang M; College of Life Sciences, Wuhan University, Wuhan, Hubei, People's Republic of China., Suraneni PK; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Li D; Department of Hematology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei, People's Republic of China., Crispino JD; Feinberg School of Medicine, Northwestern University, Chicago, IL, USA., Fan J; Department of Pediatrics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People's Republic of China., Huang Z; College of Life Sciences, Wuhan University, Wuhan, Hubei, People's Republic of China.

Publikováno v: Blood cancer journal [Blood Cancer J] 2016 Sep 30; Vol. 6 (9), pp. e478. Date of Electronic Publication: 2016 Sep 30.

Lung megakaryocytes engulf inhaled airborne particles to promote intrapulmonary inflammation and extrapulmonary distribution.

Autor: Qiu, Jiahuang, Ma, Juan, Dong, Zheng, Ren, Quanzhong, Shan, Qing’e, Liu, Jiao, Gao, Ming, Liu, Guoliang, Zhang, Shuping, Qu, Guangbo, Jiang, Guibin, Liu, Sijin

Publikováno v: Nature Communications; 8/27/2024, Vol. 15 Issue 1, p1-18, 18p

BMP2K dysregulation promotes abnormal megakaryopoiesis in acute megakaryoblastic leukemia.

Autor: Wang, Manman¹ (AUTHOR), Zhang, Tan¹ (AUTHOR), Zhang, Xuechun¹ (AUTHOR), Jiang, Zhou¹ (AUTHOR), Peng, Min² (AUTHOR) mpeng320@whu.edu.cn, Huang, Zan¹ (AUTHOR) z-huang@whu.edu.cn

Publikováno v: Cell & Bioscience. 4/15/2020, Vol. 10 Issue 1, p1-14. 14p.