Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Suraksha Gahalawat"'
Autor:
Leah S. Imlay, Aloysus K. Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Nimisha Mittal, Sergio Wittlin, Alisje Churchyard, Hanspeter Niederstrasser, Benigno Crespo-Fernandez, Bruce A. Posner, Francisco-Javier Gamo, Jake Baum, Elizabeth A. Winzeler, Benoît Laleu, Joseph M. Ready, Margaret A. Phillips
Publikováno v:
ACS Infectious Diseases. 9:527-539
Autor:
Leah S. Imlay, Aloysus K. Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Nimisha Mittal, Sergio Wittlin, Alisje Churchyard, Hanspeter Niederstrasser, Benigno Crespo-Fernandez, Bruce Posner, Francisco Javier Gamo, Jake Baum, Elizabeth A. Winzeler, Benoît Laleu, Joseph M. Ready, Margaret A. Phillips
Current malaria treatments are threatened by drug resistance and new drugs are urgently needed. In a phenotypic screen for new antimalarials, we identified (S)-SW228703 ((S)-SW703), a tyrosine amide with asexual blood and liver stage activity and a f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e075d7b4525241704c6d99d7df97273
https://doi.org/10.1101/2022.10.16.512381
https://doi.org/10.1101/2022.10.16.512381
Autor:
Sergio Wittlin, Sachel Mok, Benoît Laleu, Anwu Zhou, Susan A. Charman, Margaret A. Phillips, Tomas Yeo, David A. Fidock, Alisje Churchyard, Joseph M. Ready, Francisco-Javier Gamo, Ioanna Deni, John Okombo, Bruce A. Posner, Aloysus K. Lawong, Jessica L. Bridgford, Elizabeth A. Winzeler, Benigno Crespo, Michael J. Palmer, Hanspeter Niederstrasser, Josefine Striepen, Suraksha Gahalawat, Jake Baum, Nimisha Mittal
Publikováno v:
Journal of Medicinal Chemistry. 64:2739-2761
Malaria control programs continue to be threatened by drug resistance. To identify new antimalarials, we conducted a phenotypic screen and identified a novel tetrazole-based series that shows fast-kill kinetics and a relatively low propensity to deve
Autor:
Christopher Leija, Suraksha Gahalawat, James M. Bradford, Bin Hu, Joseph M. Ready, Hanspeter Niederstrasser, Imran Ullah, Dawn M. Wetzel, Shreoshi Majumdar, Laela M. Booshehri
Publikováno v:
ACS Infectious Diseases. 6:2057-2072
The few frontline antileishmanial drugs are poorly effective and toxic. To search for new drugs for this neglected tropical disease, we tested the activity of compounds in the Medicines for Malaria Venture (MMV) "Pathogen Box" against Leishmania amaz
Autor:
Aloysus, Lawong, Suraksha, Gahalawat, John, Okombo, Josefine, Striepen, Tomas, Yeo, Sachel, Mok, Ioanna, Deni, Jessica L, Bridgford, Hanspeter, Niederstrasser, Anwu, Zhou, Bruce, Posner, Sergio, Wittlin, Francisco Javier, Gamo, Benigno, Crespo, Alisje, Churchyard, Jake, Baum, Nimisha, Mittal, Elizabeth, Winzeler, Benoît, Laleu, Michael J, Palmer, Susan A, Charman, David A, Fidock, Joseph M, Ready, Margaret A, Phillips
Publikováno v:
J Med Chem
Malaria control programs continue to be threatened by drug resistance. To identify new antimalarials we conducted a phenotypic screen and identified a novel tetrazole-based series that shows fast-kill kinetics and a relatively low propensity to devel
Publikováno v:
Tetrahedron Letters. 58:2898-2900
An efficient asymmetric total synthesis of phomonol 1 is presented, starting from (S)-1,2-epoxypentane. The synthesis features Sharpless asymmetric dihydroxylation (AD), diastereoselective reductive etherification and Wacker oxidation as key steps.
Publikováno v:
Asian Journal of Organic Chemistry. 4:1025-1029
An efficient total synthesis of (+)-petromyroxol, a marine natural product, is described. The synthesis utilizes the Sharpless asymmetric dihydroxylation (AD), intramolecular SN2 cyclization and stereoselective Grignard reaction as key steps.
Publikováno v:
RSC Advances. 5:41013-41016
A short and highly efficient enantioselective synthetic approach to (+)-serinolamide A 1 from racemic butadiene monoepoxide as a starting material is described. The synthesis utilizes the palladium catalyzed Trost's Dynamic Kinetic Asymmetric Transfo
Publikováno v:
RSC Advances. 5:38846-38850
A simple and highly efficient synthetic approach to enantiopure 2-alkyl substituted tetrahydroquinoline 1 skeleton from aldehydes as starting materials and its application to the total synthesis of (+)-angustureine 2 is described. Key transformations
Publikováno v:
Organicbiomolecular chemistry. 14(39)
A stereoselective approach for the synthesis of haliclamide 1, a marine natural product, has been developed. The notable features of our synthesis include MacMillan cross aldol, Mitsunobu inversion, Yamaguchi–Hirao alkylation, Steglich esterificati