Výsledky vyhledávání - "Surajit, Sinha"

Akademický článek

Self-transfecting GMO-PMO chimera targeting Nanog enable gene silencing in vitro and suppresses tumor growth in 4T1 allografts in mouse

Autor: Ujjal Das, Jayanta Kundu, Pallab Shaw, Chandra Bose, Atanu Ghosh, Shalini Gupta, Sudipta Sarkar, Jhuma Bhadra, Surajit Sinha

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 203-228 (2023)

Phosphorodiamidate morpholino oligonucleotide (PMO)-based antisense reagents cannot enter cells without the help of a delivery technique, which limits their clinical applications. To overcome this problem, self-transfecting guanidinium-linked morphol

Externí odkaz: https://doaj.org/article/d7bde6f098ba45c9b258a27ecd60eeab

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Akademický článek

AUF-1 knockdown in mice undermines gut microbial butyrate-driven hypocholesterolemia through AUF-1–Dicer-1–mir-122 hierarchy

Autor: Oishika Das, Jayanta Kundu, Atanu Ghosh, Anupam Gautam, Souradeepa Ghosh, Mainak Chakraborty, Aaheli Masid, Samiran Sona Gauri, Debmalya Mitra, Moumita Dutta, Budhaditya Mukherjee, Surajit Sinha, Moumita Bhaumik

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)

Introduction and objectiveCholesterol homeostasis is a culmination of cellular synthesis, efflux, and catabolism to important physiological entities where short chain fatty acid, butyrate embodied as a key player. This discourse probes the mechanisti

Externí odkaz: https://doaj.org/article/a330c7fc5aa9497386ca7472619c2499

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C5-pyrimidine-functionalized morpholino oligonucleotides exhibit differential binding affinity, target specificity and lipophilicity

Autor: Arnab Das, Atanu Ghosh, Surajit Sinha

Publikováno v: Organic & Biomolecular Chemistry. 21:1242-1253

5-Substituted cytidine and uridine greatly enhance the duplex stability of PMOs with complementary DNA and RNA for better antisense applications.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b446ce6449cd48e7283e94974e6e4070
https://doi.org/10.1039/d2ob01759h

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Synthesis of 5′-Thiol Functionalized Morpholino Oligo-Nucleotide and Subsequent Conjugation with IGT to Improve Delivery and Antisense Efficacy In Vitro

Autor: Ujjwal Ghosh, Shalini Gupta, Surajit Sinha

Publikováno v: Bioconjugate Chemistry. 34:174-180

Thiol functionalized oligonucleotides are useful intermediates for a wide range of applications including DNA nanobiotechnology field through conjugation with various types of probes and cargos. Due to the limitation of synthetic process, phosphorodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f168f320a6f8aa83c2db77b0ba825ed8
https://doi.org/10.1021/acs.bioconjchem.2c00587

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Guanidinium-Functionalized Flexible Azaproline Transporter for Efficient Intracellular Delivery of Proapoptotic Peptide and PDL1 Antisense Morpholino Oligo in Human Carcinoma Cells In Vitro

Autor: Abhishek Gupta, Shalini Gupta, Ujjal Das, Surajit Sinha

Publikováno v: Bioconjugate Chemistry. 33:907-917

Cell-penetrating peptides (CPPs) are structurally diverse sophisticated tools endowed with high arginine content, amphipathicity, and well-adopted suitable secondary structures. Despite its capability of breaching the lipid barriers, CPP has major li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62f7b1afd8abb1ba01c2583ed51550aa
https://doi.org/10.1021/acs.bioconjchem.2c00129

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Delivery of a Laparoscopic Bile Duct Exploration Service as a Primary Treatment Modality for Choledocholithiasis within the NHS Healthcare System

Autor: Marcos, Kostalas, Petros, Christopoulos, Timothy, Platt, Surajit, Sinha, Kirk, Bowling, Gandrapu, Srinivas, Stuart, Andrews

Publikováno v: Surgical Endoscopy. 36:7462-7470

The aim of this paper was to report the experience of one-stage LC and LCBDE service within a medium sized acute NHS healthcare trust to demonstrate the feasibility of this treatment modality in terms of safety, quality and effectiveness inside the l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7271d2898edec7b41697dc6d34d96cbd
https://doi.org/10.1007/s00464-022-09157-2

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Molecularly resolved, label-free nucleic acid sensing at solid–liquid interface using non-ionic DNA analogues

Autor: Tanushree Mana, Jayanta Kundu, Hiya Lahiri, Sudipta Bera, Jayeeta Kolay, Surajit Sinha, Rupa Mukhopadhyay

Publikováno v: RSC Advances. 12:9263-9274

Improved nucleic acid sensing in terms of single nucleobase mismatch discrimination, as achieved by the surface-confined non-ionic PNA and MO capture probes, is exemplified by single molecule force spectroscopy.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cf77bf60436cc3cc790c33d80c0afa9
https://doi.org/10.1039/d2ra00386d

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