Výsledky vyhledávání - "Suraj S Shetty"

Akademický článek

Lack of authentic atrial fibrillation in commonly used murine atrial fibrillation models.

Autor: Fumin Fu, Michael Pietropaolo, Lei Cui, Shilpa Pandit, Weiyan Li, Oleg Tarnavski, Suraj S Shetty, Jing Liu, Jennifer M Lussier, Yutaka Murakami, Prabhjit K Grewal, Galina Deyneko, Gordon M Turner, Andrew K P Taggart, M Gerard Waters, Shaun Coughlin, Yuichiro Adachi

Publikováno v: PLoS ONE, Vol 17, Iss 1, p e0256512 (2022)

The mouse is a useful preclinical species for evaluating disease etiology due to the availability of a wide variety of genetically modified strains and the ability to perform disease-modifying manipulations. In order to establish an atrial filtration

Externí odkaz: https://doaj.org/article/9e4a05b9d5094a40b0cf21268159371c

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Akademický článek

India's regulations for preventing plagiarism and promoting academic integrity in higher education

Autor: Smitha Rani, Suraj S Shetty, S Sandeep

Publikováno v: Medical Journal of Dr. D.Y. Patil Vidyapeeth, Vol 15, Iss 6, Pp 943-944 (2022)

Externí odkaz: https://doaj.org/article/ffaca858721947b0a80f9824dec17a51

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Conversion of proendothelin-1 into endothelin-1 by aspartylproteases

Autor: Paula Savage, Louis L. Martin, Suraj S. Shetty, Arco Y. Jeng

Publikováno v: International Journal of Peptide and Protein Research. 42:227-232

The ability of cathepsin D, chymosin, pepsin and renin to produce endothelin-1 (ET-1) from proendothelin-1 (proET-1) was compared. No significant conversion was observed when proET-1 was incubated with up to 1 U of renin for 15 min at 37°C. Cathepsi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c8f6c90498222f9911bd96da61feda3
https://doi.org/10.1111/j.1399-3011.1993.tb00136.x

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Isoindolines: A new series of potent and selective endothelin-A receptor antagonists

Autor: Paivi Jaana Kukkola, Suraj S. Shetty, Natalie A. Bilci, Paula Savage, Theodore Ikler, Arco Y. Jeng, Dominick DelGrande

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 11:1737-1740

1,3-Disubstituted isoindolines have been discovered as a new class of potent functional ET A selective receptor antagonists through pharmacophore analysis of existing nonpeptide endothelin antagonists. The structure–activity relationships for both

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed6e1f77d9a18d7b3a45f6a318e01761
https://doi.org/10.1016/s0960-894x(01)00273-6

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Secondary Amides of (R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase

Publikováno v: Journal of Medicinal Chemistry. 43:236-249

N‘-Methyl-N-(4-tert-butyl-1,2,5,6-tetrahydropyridine)thiourea, SDZ048-619 (1), is a modest inhibitor (IC50 = 180 μM) of pyruvate dehydrogenase kinase (PDHK). In an optimization of the N-methylcarbothioamide moiety of 1, it was discovered that amid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a21921472d2095e7c5eea09d6d92805
https://doi.org/10.1021/jm990358+

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Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK)

Autor: Emma L. Kaplan, Jiaping Gao, Leonard J. Brand, Robert E. Damon, Judit Koletar, Christine C. Vinluan, Suraj S. Shetty, Thomas Daniel Aicher, William R. Mann

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 9:2223-2228

Several oximes of triterpenes with a 17-beta hydroxyl and abietane derivatives are inhibitors of pyruvate dehydrogenase kinase (PDK) activity. The oxime 12 and dehydroabietyl amine 2 exhibit a blood glucose lowering effect in the diabetic ob/ob mouse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7845fb3e46576be1780877fa834d49f
https://doi.org/10.1016/s0960-894x(99)00380-7

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