Výsledky vyhledávání - "Suraj S, Vasanthi"

Akademický článek

Disease-modifying effects of a glial-targeted inducible nitric oxide synthase inhibitor (1400W) in mixed-sex cohorts of a rat soman (GD) model of epilepsy

Autor: Suraj S. Vasanthi, Nikhil S. Rao, Manikandan Samidurai, Nyzil Massey, Christina Meyer, Meghan Gage, Mihir Kharate, Aida Almanza, Logan Wachter, Candide Mafuta, Lily Trevino, Adriana M. Carlo, Elijah Bryant, Brooke E. Corson, Morgan Wohlgemuth, Morgan Ostrander, Lucas Showman, Chong Wang, Thimmasettappa Thippeswamy

Publikováno v: Journal of Neuroinflammation, Vol 20, Iss 1, Pp 1-25 (2023)

Abstract Background Acute exposure to seizurogenic organophosphate (OP) nerve agents (OPNA) such as diisopropylfluorophosphate (DFP) or soman (GD), at high concentrations, induce immediate status epilepticus (SE), reactive gliosis, neurodegeneration,

Externí odkaz: https://doaj.org/article/27b5448e94704f1a86180ed9deaf58b0

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Akademický článek

Sex‐based structural and functional MRI outcomes in the rat brain after soman (GD) exposure‐induced status epilepticus

Autor: Meghan Gage, Suraj S Vasanthi, Christina M Meyer, Nikhil S Rao, Daniel R Thedens, Sridhar S. Kannurpatti, Thimmasettappa Thippeswamy

Publikováno v: Epilepsia Open, Vol 8, Iss 2, Pp 399-410 (2023)

Abstract Objective Exposure to the nerve agent, soman (GD), induces status epilepticus (SE), epileptogenesis, and even death. Although rodent models studying the pathophysiological mechanisms show females to be more reactive to soman, no tangible sex

Externí odkaz: https://doaj.org/article/5cf3a7149c2048d9ab198687bb4291b4

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Akademický článek

Exploring the benefits of in-diet versus repeated oral dosing of saracatinib (AZD0530) in chronic studies: insights into pharmacokinetics and animal welfare

Autor: Suraj S. Vasanthi, Nyzil Massey, Suresh N. Nair, Jonathan P. Mochel, Lucas Showman, Thimmasettappa Thippeswamy

Publikováno v: Frontiers in Veterinary Science, Vol 10 (2023)

Saracatinib/AZD0530 (SAR), a Src tyrosine kinase inhibitor, mitigates seizure-induced brain pathology in epilepsy models upon repeated oral dosing. However, repeated dosing is stressful and can be challenging in some seizing animals. To overcome this

Externí odkaz: https://doaj.org/article/7c514cee98144e1db9ae0052e453e9fa

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Akademický článek

Peripheral and central effects of NADPH oxidase inhibitor, mitoapocynin, in a rat model of diisopropylfluorophosphate (DFP) toxicity

Autor: Christina Meyer, Nikhil S. Rao, Suraj S. Vasanthi, Beatriz Pereira, Meghan Gage, Marson Putra, Claire Holtkamp, Joselyn Huss, Thimmasettappa Thippeswamy

Publikováno v: Frontiers in Cellular Neuroscience, Vol 17 (2023)

Organophosphates (OP) are highly toxic chemical nerve agents that have been used in chemical warfare. Currently, there are no effective medical countermeasures (MCMs) that mitigate the chronic effects of OP exposure. Oxidative stress is a key mechani

Externí odkaz: https://doaj.org/article/ee60e460bdda414980be652438df1986

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Akademický článek

The NADPH Oxidase Inhibitor, Mitoapocynin, Mitigates DFP-Induced Reactive Astrogliosis in a Rat Model of Organophosphate Neurotoxicity

Autor: Christina Meyer, Elizabeth Grego, Suraj S. Vasanthi, Nikhil S. Rao, Nyzil Massey, Claire Holtkamp, Joselyn Huss, Lucas Showman, Balaji Narasimhan, Thimmasettappa Thippeswamy

Publikováno v: Antioxidants, Vol 12, Iss 12, p 2061 (2023)

NADPH oxidase (NOX) is a primary mediator of superoxides, which promote oxidative stress, neurodegeneration, and neuroinflammation after diisopropylfluorophosphate (DFP) intoxication. Although orally administered mitoapocynin (MPO, 10 mg/kg), a mitoc

Externí odkaz: https://doaj.org/article/331dd32870e5452ba3ebce96b8785c24

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Akademický článek

DFP-Induced Status Epilepticus Severity in Mixed-Sex Cohorts of Adult Rats Housed in the Same Room: Behavioral and EEG Comparisons

Autor: Nikhil S. Rao, Christina Meyer, Suraj S. Vasanthi, Nyzil Massey, Manikandan Samidurai, Meghan Gage, Marson Putra, Aida N. Almanza, Logan Wachter, Thimmasettappa Thippeswamy

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 10 (2022)

Sex is a biological variable in experimental models. In our previous diisopropylfluorophosphate (DFP) studies, female rats required a higher dose of DFP to achieve a somewhat similar severity of status epilepticus (SE) as males. In those studies, mal

Externí odkaz: https://doaj.org/article/3365a7c48d5447a38cc68c990cfcd13b

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Akademický článek

Soman (GD) Rat Model to Mimic Civilian Exposure to Nerve Agent: Mortality, Video-EEG Based Status Epilepticus Severity, Sex Differences, Spontaneously Recurring Seizures, and Brain Pathology

Autor: Meghan Gage, Nikhil S. Rao, Manikandan Samidurai, Marson Putra, Suraj S. Vasanthi, Christina Meyer, Chong Wang, Thimmasettappa Thippeswamy

Publikováno v: Frontiers in Cellular Neuroscience, Vol 15 (2022)

Modeling a real-world scenario of organophosphate nerve agent (OPNA) exposure is challenging. Military personnel are premedicated with pyridostigmine, which led to the development of OPNA models with pyridostigmine/oxime pretreatment to investigate n

Externí odkaz: https://doaj.org/article/631974d04d3d4aefa5b682931e544a3c

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