Zobrazeno 1 - 10
of 202
pro vyhledávání: '"Suraj Peri"'
Autor:
Jill W. Ford, Marieli Gonzalez-Cotto, Alexander W. MacFarlane, Suraj Peri, O. M. Zack Howard, Jeffrey J. Subleski, Karen J. Ruth, Mohammed Haseebuddin, Tahseen Al-Saleem, Youfeng Yang, Pat Rayman, Brian Rini, W. Marston Linehan, James Finke, Jonathan M. Weiss, Kerry S. Campbell, Daniel W. McVicar
Publikováno v:
Frontiers in Oncology, Vol 11 (2022)
Myeloid-derived suppressor cells (MDSC) and tumor-associated macrophages (TAM) contribute to cancer-related inflammation and tumor progression. While several myeloid molecules have been ascribed a regulatory function in these processes, the triggerin
Externí odkaz:
https://doaj.org/article/b29a1d769f3c4074858d8da7e828b13c
Autor:
David Olagnier, Ensieh Farahani, Jacob Thyrsted, Julia Blay-Cadanet, Angela Herengt, Manja Idorn, Alon Hait, Bruno Hernaez, Alice Knudsen, Marie Beck Iversen, Mirjam Schilling, Sofie E. Jørgensen, Michelle Thomsen, Line S. Reinert, Michael Lappe, Huy-Dung Hoang, Victoria H. Gilchrist, Anne Louise Hansen, Rasmus Ottosen, Camilla G. Nielsen, Charlotte Møller, Demi van der Horst, Suraj Peri, Siddharth Balachandran, Jinrong Huang, Martin Jakobsen, Esben B. Svenningsen, Thomas B. Poulsen, Lydia Bartsch, Anne L. Thielke, Yonglun Luo, Tommy Alain, Jan Rehwinkel, Antonio Alcamí, John Hiscott, Trine H. Mogensen, Søren R. Paludan, Christian K. Holm
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Viral infections usually cause disease through direct cytopathogenic effects and excessive inflammatory responses. Here, Olagnier et al. show that two NRF2 agonists, 4-OI and DMF, possess broad IFN-independent antiviral activity and decrease host inf
Externí odkaz:
https://doaj.org/article/7eb1ed3741cc4fbfa366937b0037cc35
Autor:
Yifan Wang, Andrea J. Bernhardy, Joseph Nacson, John J. Krais, Yin-Fei Tan, Emmanuelle Nicolas, Marc R. Radke, Elizabeth Handorf, Alba Llop-Guevara, Judith Balmaña, Elizabeth M. Swisher, Violeta Serra, Suraj Peri, Neil Johnson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
BRCA1 mutations located within the BRCT domain result in proteasomal degradation and sensitivity to PARP inhibitors (PARPi). Here, the authors report genetic rearrangements in the BRCA1 gene that generate a BRCT-less BRCA1 protein isoform, which avoi
Externí odkaz:
https://doaj.org/article/67c22e7b21e74d119a7920f907472b4a
Autor:
Aizhan Surumbayeva, Michael Kotliar, Linara Gabitova-Cornell, Andrey Kartashov, Suraj Peri, Nathan Salomonis, Artem Barski, Igor Astsaturov
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100989- (2021)
Summary: Preparation of single-cell suspension from primary tumor tissue can provide a valuable resource for functional, genetic, proteomic, and tumor microenvironment studies. Here, we describe an effective protocol for mouse pancreatic tumor dissoc
Externí odkaz:
https://doaj.org/article/589e50c6390a4226890022c165a66ffb
Autor:
Julia Santucci-Pereira, Anne Zeleniuch-Jacquotte, Yelena Afanasyeva, Hua Zhong, Michael Slifker, Suraj Peri, Eric A. Ross, Ricardo López de Cicco, Yubo Zhai, Theresa Nguyen, Fathima Sheriff, Irma H. Russo, Yanrong Su, Alan A. Arslan, Pal Bordas, Per Lenner, Janet Åhman, Anna Stina Landström Eriksson, Robert Johansson, Göran Hallmans, Paolo Toniolo, Jose Russo
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-19 (2019)
Abstract Background Full-term pregnancy (FTP) at an early age confers long-term protection against breast cancer. Previously, we reported that a FTP imprints a specific gene expression profile in the breast of postmenopausal women. Herein, we evaluat
Externí odkaz:
https://doaj.org/article/c2f136d8ce95499fa24fca1f8a2b5501
Autor:
David Olagnier, Aske M. Brandtoft, Camilla Gunderstofte, Nikolaj L. Villadsen, Christian Krapp, Anne L. Thielke, Anders Laustsen, Suraj Peri, Anne Louise Hansen, Lene Bonefeld, Jacob Thyrsted, Victor Bruun, Marie B. Iversen, Lin Lin, Virginia M. Artegoitia, Chenhe Su, Long Yang, Rongtuan Lin, Siddharth Balachandran, Yonglun Luo, Mette Nyegaard, Bernadette Marrero, Raphaela Goldbach-Mansky, Mona Motwani, Dylan G. Ryan, Katherine A. Fitzgerald, Luke A. O’Neill, Anne K. Hollensen, Christian K. Damgaard, Frank v. de Paoli, Hanne C. Bertram, Martin R. Jakobsen, Thomas B. Poulsen, Christian K. Holm
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Understanding how regulators of inflammation affect nucleic acid sensing is important for targeting research against inflammatory diseases and conditions. Here, the authors identify Nrf2 as an important negative regulator of STING and suggest a link
Externí odkaz:
https://doaj.org/article/5fc54bf6fbd8427c94401b47231854b6
Autor:
Elizabeth M. Matthew, Zhaohai Yang, Suraj Peri, Mark Andrake, Roland Dunbrack, Eric Ross, Wafik S. El-Deiry
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 3, Pp 244-255 (2018)
Plk2 is a target of p53. Our previous studies demonstrated that with wild-type p53, Plk2 impacts mTOR signaling in the same manner as TSC1, and Plk2-deficient tumors grew larger than control. Other investigators have demonstrated that Plk2 phosphoryl
Externí odkaz:
https://doaj.org/article/5fccdcace29144b28dbe9dde7e501968
Autor:
Suraj Peri, Evgeny Izumchenko, Adrian D. Schubert, Michael J. Slifker, Karen Ruth, Ilya G. Serebriiskii, Theresa Guo, Barbara A. Burtness, Ranee Mehra, Eric A. Ross, David Sidransky, Erica A. Golemis
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The authors use an integrative clustering approach to identify two laryngeal cancer clusters with distinct prognosis and show that mutations damaging the NSD1 and NSD2 methyltransferases segregate to the cluster with favorable prognosis, and independ
Externí odkaz:
https://doaj.org/article/eddde834c4f34581ae63259cb1d66acc
Autor:
Yong Zhang, Monique N. O’Leary, Suraj Peri, Minshi Wang, Jikun Zha, Simon Melov, Dietmar J. Kappes, Qing Feng, Jennifer Rhodes, Paul S. Amieux, David R. Morris, Brian K. Kennedy, David L. Wiest
Publikováno v:
Cell Reports, Vol 18, Iss 2, Pp 545-556 (2017)
Summary: Most ribosomal proteins (RP) are regarded as essential, static components that contribute only to ribosome biogenesis and protein synthesis. However, emerging evidence suggests that RNA-binding RP are dynamic and can influence cellular proce
Externí odkaz:
https://doaj.org/article/9e4393a48121414fab9cb2a60ae7c28b
Autor:
Camilla Gunderstofte, Marie Beck Iversen, Suraj Peri, Anne Thielke, Siddharth Balachandran, Christian Kanstrup Holm, David Olagnier
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Herpes simplex virus-2 (HSV-2) is a leading cause of sexually transmitted infections for which no effective vaccines or prophylactic treatment currently exist. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor involved in t
Externí odkaz:
https://doaj.org/article/2c4c7ade5fba4afea79db4b7aa15877d