Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Suraj P. Bhat"'
Autor:
Rajendra K. Gangalum, Dongjae Kim, Raj K. Kashyap, Serghei Mangul, Xinkai Zhou, David Elashoff, Suraj P. Bhat
Publikováno v:
iScience, Vol 10, Iss , Pp 66-79 (2018)
Summary: The developing eye lens presents an exceptional paradigm for spatial transcriptomics. It is composed of highly organized long, slender transparent fiber cells, which differentiate from the edges of the anterior epithelium of the lens (equato
Externí odkaz:
https://doaj.org/article/a493aba06cc04dd1bca19b72926c505c
Publikováno v:
BioTechniques, Vol 51, Iss 5, Pp 335-337 (2011)
An unresolved bottleneck in bacterial artificial chromosome (BAC) transgenesis is low efficiency generation of founder mice because of suboptimal quality of the manipulated BAC DNA. Using mini-gel electrophoresis and electro-elution that circumvents
Externí odkaz:
https://doaj.org/article/36f103a8aa384b03b9b294c3ae32d2ce
Autor:
Dongjae Kim, Rajendra K. Gangalum, Suraj P. Bhat, Raj K. Kashyap, Xinkai Zhou, David Elashoff, Serghei Mangul
Publikováno v:
The Journal of Biological Chemistry
The Journal of biological chemistry, vol 294, iss 37
The Journal of biological chemistry, vol 294, iss 37
Our recent single-cell transcriptomic analysis has demonstrated that heterogeneous transcriptional activity attends molecular transition from the nascent to terminally differentiated fiber cells in the developing mouse lens. To understand the role of
Autor:
Suraj P. Bhat, Rajendra K. Gangalum, Raj K. Kashyap, Xinkai Zhou, Dongjae Kim, Serghei Mangul, David Elashoff
Publikováno v:
iScience, Vol 10, Iss, Pp 66-79 (2018)
iScience
iScience
Summary The developing eye lens presents an exceptional paradigm for spatial transcriptomics. It is composed of highly organized long, slender transparent fiber cells, which differentiate from the edges of the anterior epithelium of the lens (equator
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33582 (2012)
The small heat shock protein, αA-crystallin null (αA-/-) mice are known to be more prone to retinal degeneration than the wild type mice in Experimental Autoimmune Uveoretinitis (EAU). In this report we demonstrate that intravenous administration o
Externí odkaz:
https://doaj.org/article/386571f660124bc183f8fdd94d94d771
The developing ocular lens: A practical paradigm for probing chromatin landscape and gene expression
Autor:
Suraj P. Bhat
Publikováno v:
Dev Biol
Changes in chromatin accessibility regulate the expression of multiple genes by controlling transcription factor access to key gene regulatory sequences. Here, we sought to establish a potential function for altered chromatin accessibility in control
Autor:
Dongjae Kim, Rajendra K. Gangalum, Raj K. Kashyap, Suraj P. Bhat, Zhou Xinxai, David Elashoff, Serghei Mangul
Publikováno v:
SSRN Electronic Journal.
We have shown recently that highly variable transcriptional activity in single cortical fiber cells mediates the transition from nascent to terminally differentiated fiber cells in the developing ocular lens. The lens is composed of only two cell typ
Autor:
Ankur M. Bhat, Yoshiko Nagaoka, Suraj P. Bhat, Meisheng Jiang, Zhe Jing, Rajendra K. Gangalum
Publikováno v:
Human Mutation. 35:1068-1071
The p.Arg116His mutation in the heat shock transcription factor-4 (HSF4) has been associated with age-related cataracts, but it is also seen in 2% of the normal population, indicating either reduced penetrance or that the normal subjects were not old
Publikováno v:
Journal of Biological Chemistry. 287:42407-42416
αA-Crystallin (αA) and αB-crystallin (αB), the two prominent members of the small heat shock family of proteins are considered to be two subunits of one multimeric protein, α-crystallin, within the ocular lens. Outside of the ocular lens, howeve
Publikováno v:
The Journal of biological chemistry, vol 291, iss 25
Exosomes carry cell type-specific molecular cargo to extracellular destinations and therefore act as lateral vectors of intercellular communication and transfer of genetic information from one cell to the other. We have shown previously that the smal