Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Suraj J. Patel"'
Autor:
Frankie D. Heyward, Nan Liu, Christopher Jacobs, Natalia L. S. Machado, Rachael Ivison, Aykut Uner, Harini Srinivasan, Suraj J. Patel, Anton Gulko, Tyler Sermersheim, Linus Tsai, Evan D. Rosen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract AgRP neurons in the arcuate nucleus of the hypothalamus (ARC) coordinate homeostatic changes in appetite associated with fluctuations in food availability and leptin signaling. Identifying the relevant transcriptional regulatory pathways in
Externí odkaz:
https://doaj.org/article/cb1199e1ff5441d09265e83f4a574091
Autor:
Augustin G.L. Vannier, Vladislav Fomin, Raymond T. Chung, Suraj J. Patel, Esperance Schaefer, Russell P. Goodman, Jay Luther
Publikováno v:
Gastro Hep Advances, Vol 1, Iss 3, Pp 403-408 (2022)
Background and Aims: Substance use disorder (SUD) commonly associates with alcohol use disorder (AUD), and certain substances have independently been shown to drive liver injury. In this work, we sought to determine if coexisting SUD in patients with
Externí odkaz:
https://doaj.org/article/7f8b084d86a2474ab4029a943598778d
Autor:
Jay Luther, Manish K. Gala, Nynke Borren, Ricard Masia, Russell P. Goodman, Ida Hatoum Moeller, Erik DiGiacomo, Alyssa Ehrlich, Andrew Warren, Martin L. Yarmush, Ashwin Ananthakrishnan, Kathleen Corey, Lee M. Kaplan, Sangeeta Bhatia, Raymond T. Chung, Suraj J. Patel
Publikováno v:
Hepatology Communications, Vol 2, Iss 7, Pp 786-797 (2018)
Emerging data highlight the critical role for the innate immune system in the progression of nonalcoholic fatty liver disease (NAFLD). Connexin 32 (Cx32), the primary liver gap junction protein, is capable of modulating hepatic innate immune response
Externí odkaz:
https://doaj.org/article/0b33ca27a2f6465a8fd46af88a7384a3
Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal PermeabilitySummary
Autor:
Jay Luther, John J. Garber, Hamed Khalili, Maneesh Dave, Shyam Sundhar Bale, Rohit Jindal, Daniel L. Motola, Sanjana Luther, Stefan Bohr, Soung Won Jeoung, Vikram Deshpande, Gurminder Singh, Jerrold R. Turner, Martin L. Yarmush, Raymond T. Chung, Suraj J. Patel
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 1, Iss 2, Pp 222-232.e2 (2015)
Background & Aims: Emerging data suggest that changes in intestinal permeability and increased gut microbial translocation contribute to the inflammatory pathway involved in nonalcoholic steatohepatitis (NASH) development. Numerous studies have inves
Externí odkaz:
https://doaj.org/article/af64a40e688a4485a116866d0e616577
We describe the design, generation, and in vitro evaluation of targeted amphipathic fusion peptides and immunoconjugates for the ablation of prostate cancer cells. The overexpression of the prostate-specific membrane antigen (PSMA) was exploited as m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::804a5a0f86cacc0518b1b26a9f8f9975
https://doi.org/10.1158/0008-5472.c.6495815
https://doi.org/10.1158/0008-5472.c.6495815
Supplementary Figures 1-2 from Amphipathic Peptide-Based Fusion Peptides and Immunoconjugates for the Targeted Ablation of Prostate Cancer Cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33b88e9d7f9bd11c0cb637b5c69a5d62
https://doi.org/10.1158/0008-5472.22368113.v1
https://doi.org/10.1158/0008-5472.22368113.v1
Autor:
Augustin G L, Vannier, Eric M, Przybyszewski, Jessica, Shay, Suraj J, Patel, Esperance, Schaefer, Russell P, Goodman, Jay, Luther
Publikováno v:
Clinical Gastroenterology and Hepatology. 21:1571-1580.e7
Alcohol-associated liver disease (ALD) is a devastating complication of alcohol use disorder (AUD). Once it develops, ALD is exceedingly difficult to treat; it therefore is critical to identify ways to prevent ALD. By treating the causes of increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54b1dbb3fde8f7e07108237ccd41871
https://doi.org/10.1016/j.cgh.2022.08.001
https://doi.org/10.1016/j.cgh.2022.08.001
Autor:
Augustin G. L. Vannier, Jessica E. S. Shay, Vladislav Fomin, Suraj J. Patel, Esperance Schaefer, Russell P. Goodman, Jay Luther
Publikováno v:
JAMA network open. 5(5)
Alcohol-associated liver disease (ALD) is one of the most devastating complications of alcohol use disorder (AUD), an increasingly prevalent condition. Medical addiction therapy for AUD may play a role in protecting against the development and progre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd7576f6a1da8a5464180865ae9870a1
https://pubmed.ncbi.nlm.nih.gov/35594051
https://pubmed.ncbi.nlm.nih.gov/35594051
Autor:
Suraj J. Patel, Nan Liu, Sam Piaker, Anton Gulko, Maynara L. Andrade, Frankie D. Heyward, Tyler Sermersheim, Nufar Edinger, Harini Srinivasan, Margo P. Emont, Gregory P. Westcott, Jay Luther, Raymond T. Chung, Shuai Yan, Manju Kumari, Reeby Thomas, Yann Deleye, André Tchernof, Phillip J. White, Guido A. Baselli, Marica Meroni, Dario F. De Jesus, Rasheed Ahmad, Rohit N. Kulkarni, Luca Valenti, Linus Tsai, Evan D. Rosen
Publikováno v:
Sci Transl Med
Inflammation has profound but poorly understood effects on metabolism, especially in the context of obesity and nonalcoholic fatty liver disease (NAFLD). Here, we report that hepatic interferon regulatory factor 3 (IRF3) is a direct transcriptional r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e63c4bdec4a35f105f8ee128e46749
https://pubmed.ncbi.nlm.nih.gov/35444297
https://pubmed.ncbi.nlm.nih.gov/35444297
Autor:
Frankie D. Heyward, Nan Liu, Christopher Jacobs, Rachael Ivison, Natalia Machado, Aykut Uner, Harini Srinivasan, Suraj J. Patel, Anton Gulko, Tyler Sermersheim, Stuart H. Orkin, Linus Tsai, Evan D. Rosen
AgRP neurons in the arcuate nucleus of the hypothalamus (ARC) coordinate homeostatic changes in appetite associated with fluctuations in food availability and leptin signaling. Identifying the relevant transcriptional regulatory pathways in these neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b587b056ff94a8c93cdb3befb59dc569
https://doi.org/10.1101/2022.01.03.474708
https://doi.org/10.1101/2022.01.03.474708