PRSS2 stimulates tumor growth by remodeling the TME via repression of Tsp1

Autor: William D. Foulkes, Ole J. Halvorsen, Zhou K, Arturas Ziemys, Cecilie Askeland, Mittall, Svein A. Haukaas, Suming Wang, Lufei Sui, Debolina Ganguly, Gøril Knutsvik, Brekken Ra, Randy Watnick, Astrid Børretzen, Sura Mohammed Aziz, Danielle Sim, El Rayes T, Lars A. Akslen, Diane R. Bielenberg

In the earliest stages of tumor development, epithelial tumors (carcinomas) are physically confined to the area of the tissue in which they form. These nascent lesions (carcinomas in situ) are sequestered from the tissue parenchyma by the basement me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4da2ecebee24714c31031e046cc3915c
https://doi.org/10.1101/2021.03.23.436667

AXL Is a Driver of Stemness in Normal Mammary Gland and Breast Cancer

Autor: Noelly Madeleine, Sturla Magnus Grøndal, Jean Paul Thiery, Ole W. Petersen, James B. Lorens, Nils Halberg, Agnete S.T. Engelsen, Sushil Dhakal, Fanny A. Pelissier Vatter, Maria Lie Lotsberg, Masaru Miyano, René Villadsen, Tuan Zea Tan, Therese Sørlie, Sura Mohammed Aziz, Oddbjørn Straume, Lars Herfindal, Rolf A. Brekken, Lars A. Akslen, Gro Gausdal, Mark A. LaBarge, Pouda Panahandeh, Silje Nord, Martha R. Stampfer, Crina Tiron, Sébastien Bougnaud, Katarzyna Wnuk-Lipinska, Stacey D’mello Peters

Publikováno v: Engelsen, A S T, Wnuk-Lipinska, K, Bougnaud, S, Pelissier Vatter, F A, Tiron, C, Villadsen, R, Miyano, M, Lotsberg, M L, Madeleine, N, Panahandeh, P, Dhakal, S, Tan, T Z, Peters, S D M, Grøndal, S, Aziz, S M, Nord, S, Herfindal, L, Stampfer, M R, Sørlie, T, Brekken, R A, Straume, O, Halberg, N, Gausdal, G, Thiery, J P, Akslen, L A, Petersen, O W, LaBarge, M A & Lorens, J B 2020, ' AXL Is a Driver of Stemness in Normal Mammary Gland and Breast Cancer ', iScience, vol. 23, no. 11, 101649 . https://doi.org/10.1016/j.isci.2020.101649
iScience, Vol 23, Iss 11, Pp 101649-(2020)
iScience

Summary The receptor tyrosine kinase AXL is associated with epithelial plasticity in several solid tumors including breast cancer and AXL-targeting agents are currently in clinical trials. We hypothesized that AXL is a driver of stemness traits in ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::961a3d9015d3bd3df34ba6cd1716894b
https://curis.ku.dk/ws/files/250816487/1_s2.0_S2589004220308415_main.pdf

Abstract P4-12-02: Serum-triglycerides among triple negative breast cancer patients as a biomarker of poor outcome

Autor: Hawa Nalwoga, Lars A. Akslen, Trygve Lofterød, JB Reitan, Hanne Frydenberg, Erik Wist, Anne McTiernan, Terje Risberg, Sura Mohammed Aziz, Tom Wilsgaard, Elin Synnøve Mortensen, AE Eggen, Inger Thune

Publikováno v: Cancer Research. 77:P4-12

Backgound: Obesity and related metabolic imbalances, including increased activity of free fatty acids, may promote tumor growth and metastasis. Fatty acids are mainly stored as triacylglycerols. Yet, the role of serum-triglycerides on breast cancer p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5afdb9763ee5e87f27cc2089d58c42b8
https://doi.org/10.1158/1538-7445.sabcs16-p4-12-02

Associations between ABO blood groups and pancreatic ductal adenocarcinoma: influence on resection status and survival

Autor: Sura Mohammed Aziz, Khadija El Jellas, Solrun J. Steine, May Britt Kalvenes, Anders Molven, Stefan Johansson, Heike Immervoll, Dag Hoem, Kristin Gjerde Hagen

Publikováno v: Cancer Medicine

Both serology‐based and genetic studies have reported an association between pancreatic cancer risk and ABO blood groups. We have investigated this relationship in a cohort of pancreatic cancer patients from Western Norway (n = 237) and two control

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a9418cd1ec40708f452b42c090afa01
https://hdl.handle.net/1956/18389

Evaluation of Tumor Cell Proliferation by Ki-67 Expression and Mitotic Count in Lymph Node Metastases from Breast Cancer

Autor: Gøril Knutsvik, Hans Aas, Turid Aas, Tor Audun Klingen, Sura Mohammed Aziz, Benedicte Davidsen, Elisabeth Wik, Lars A. Akslen, Ying Chen

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0150979 (2016)
PLoS ONE

Few studies have addressed the risk of recurrence by assessing proliferation markers in lymph node metastasis from breast cancer. Here, we aimed to examine Ki-67 expression and mitotic count in lymph nodes in comparison with primary tumors. A cohort

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dab152dcac960b8d4c047982c0242cd7
http://europepmc.org/articles/PMC4783103?pdf=render