Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Supriyadi Hafiz"'
Autor:
Michelle Pascale Zoeller, Supriyadi Hafiz, Andreas Marx, Nelli Erwin, Gert Fricker, John F. Carpenter
Publikováno v:
Journal of pharmaceutical sciences. 111(12)
The application of surfactants in liquid protein formulation is a common practice to protect proteins from liquid-air interface-induced protein aggregation. Typically, Polysorbate 20 or 80 are used, but degradation of these surfactants can result in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f3734695375e0e64be13f78aff4de7
https://pubmed.ncbi.nlm.nih.gov/36096287
https://pubmed.ncbi.nlm.nih.gov/36096287
Publikováno v:
Journal of Chromatography B. 1214:123563
Aggregation of proteins is a critical quality attribute and a major concern during the purification of therapeutic proteins, like monoclonal antibodies. In-solution experiments applying different stress scenarios, e.g., mechanical, or physical stress
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d7c1b2507fda5a2a07337f3f4b7ecb1
https://doi.org/10.1016/j.jchromb.2022.123563
https://doi.org/10.1016/j.jchromb.2022.123563
Publikováno v:
Journal of Chromatography B. 1179:122848
The purification of monoclonal antibodies and Fc fusion proteins consist of several unit operations operated commonly as a platform approach, starting with Protein A chromatography. The first capture step, the following low pH virus inactivation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064c9d4d2c8911684e781f602ff1303a
https://doi.org/10.1016/j.jchromb.2021.122848
https://doi.org/10.1016/j.jchromb.2021.122848