Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Supriya Ramesha"'
Autor:
Ari Sudwarts, Supriya Ramesha, Tianwen Gao, Moorthi Ponnusamy, Shuai Wang, Mitchell Hansen, Alena Kozlova, Sara Bitarafan, Prateek Kumar, David Beaulieu-Abdelahad, Xiaolin Zhang, Lisa Collier, Charles Szekeres, Levi B. Wood, Jubao Duan, Gopal Thinakaran, Srikant Rangaraju
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-27 (2022)
Abstract Background The BIN1 locus contains the second-most significant genetic risk factor for late-onset Alzheimer’s disease. BIN1 undergoes alternate splicing to generate tissue- and cell-type-specific BIN1 isoforms, which regulate membrane dyna
Externí odkaz:
https://doaj.org/article/5b885f3d291245d3b19ec792e0b820ed
Autor:
Sruti Rayaprolu, Tianwen Gao, Hailian Xiao, Supriya Ramesha, Laura D. Weinstock, Jheel Shah, Duc M. Duong, Eric B. Dammer, James A. Webster, James J. Lah, Levi B. Wood, Ranjita Betarbet, Allan I. Levey, Nicholas T. Seyfried, Srikant Rangaraju
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-22 (2020)
Abstract Background Proteomic characterization of microglia provides the most proximate assessment of functionally relevant molecular mechanisms of neuroinflammation. However, microglial proteomics studies have been limited by low cellular yield and
Externí odkaz:
https://doaj.org/article/d7c72d1d44654f4abfd3eb413217f735
Autor:
Tianwen Gao, Syed Ali Raza, Supriya Ramesha, Ngozi V. Nwabueze, Amelia J. Tomkins, Lihong Cheng, Hailian Xiao, Manuel Yepes, Srikant Rangaraju
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-11 (2019)
Abstract Background Microglia and CNS-infiltrating monocytes/macrophages (CNS-MPs) perform pro-inflammatory and protective anti-inflammatory functions following ischemic stroke. Selective inhibition of pro-inflammatory responses can be achieved by Kv
Externí odkaz:
https://doaj.org/article/1e7c74655e0240a7b3d0ea507bb54c77
Autor:
Levi B. Wood, Hailian Xiao, Supriya Ramesha, Srikant Rangaraju, Laura D. Weinstock, Eric B. Dammer, James J. Lah, Duc D Duong, Nicholas T. Seyfried, Lingyan Ping, Michael J. Chen, Tianwen Gao, Allan I. Levey
Publikováno v:
J Neurosci Res
The importance of mitogen-activated protein kinase (MAPK) pathway signaling in regulating microglia-mediated neuroinflammation in Alzheimer’s disease (AD) remains unclear. We examined the role of MAPK signaling in microglia using a preclinical mode
Autor:
Jon T. Willie, Daniel L. Drane, Ammar Kheder, Kunal Gupta, Ranliang Hu, Brian T. Cabaniss, Christopher W. Rich, Supriya Ramesha, Satyanarayana Gedela, Abdulrahman Alwaki, Robert E. Gross, Kelsey C. Hewitt, Paul Koch
Publikováno v:
Epilepsia
OBJECTIVE Magnetic resonance imaging (MRI)-guided laser interstitial thermal therapy (MRg-LITT) is an alternative to open epilepsy surgery. We assess safety and effectiveness of MRg-LITT for extratemporal lobe epilepsy (ETLE) in patients who are cons
Publikováno v:
Alzheimer's & Dementia. 17
Autor:
Ngozi V. Nwabueze, Nicholas T. Seyfried, Andrea Pennati, Sruti Rayaprolu, Tianwen Gao, Levi B. Wood, Hailian Xiao, Heike Wulff, Sara Bitarafan, Michael J. Chen, Srikant Rangaraju, Christine A. Bowen, Eric B. Dammer, Supriya Ramesha, Edmund K. Waller, Amanda K. Engstrom, Allan I. Levey, Jacques Galipeau, Hai M. Nguyen, Cynthia R. Giver, David J. Katz
Publikováno v:
Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 11
Proceedings of the National Academy of Sciences of the United States of America, vol 118, iss 11
Kv1.3 potassium channels, expressed by proinflammatory central nervous system mononuclear phagocytes (CNS-MPs), are promising therapeutic targets for modulating neuroinflammation in Alzheimer’s disease (AD). The molecular characteristics of Kv1.3-h
Publikováno v:
J Vis Exp
Microglia and central nervous system (CNS)-infiltrating macrophages, collectively called CNS mononuclear phagocytes (CNS-MPs), play central roles in neurological diseases including neurodegeneration and stroke. CNS-MPs are involved in phagocytic clea
Autor:
Jheel Shah, Supriya Ramesha, Eric B. Dammer, James J. Lah, Nicholas T. Seyfried, Laura D. Weinstock, Levi B. Wood, Hailian Xiao, Duc M. Duong, Ranjita Betarbet, James A. Webster, Srikant Rangaraju, Tianwen Gao, Sruti Rayaprolu, Allan I. Levey
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-22 (2020)
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-22 (2020)
Background Proteomic characterization of microglia provides the most proximate assessment of functionally relevant molecular mechanisms of neuroinflammation. However, microglial proteomics studies have been limited by low cellular yield and contamina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f299fee9144cda7a5b8f0bd0b98cedbf
https://doi.org/10.1101/802694
https://doi.org/10.1101/802694
Autor:
Levi B. Wood, Levey Ai, Hailian Xiao, Eric B. Dammer, Srikant Rangaraju, Lah Jj, Tianwen Gao, Laura D. Weinstock, Duong Dd, Michael J. Chen, Lingyan Ping, Supriya Ramesha, Nicholas T. Seyfried
BackgroundThe mitogen-activated protein kinase (MAPK) pathway is a central regulator of gene expression, pro-survival signaling, and inflammation. However, the importance of MAPK pathway signaling in regulating microglia-mediated neuroinflammation in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f4bf353f23b565c35a9970841361c2