Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Supriya A Gaitonde"'
Autor:
Elk Kossatz, Rebeca Diez-Alarcia, Supriya A. Gaitonde, Carla Ramon-Duaso, Tomasz Maciej Stepniewski, David Aranda-Garcia, Itziar Muneta-Arrate, Elodie Tepaz, Suwipa Saen-Oon, Robert Soliva, Aida Shahraki, David Moreira, Jose Brea, Maria Isabel Loza, Rafael de la Torre, Peter Kolb, Michel Bouvier, J. Javier Meana, Patricia Robledo, Jana Selent
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract G protein-coupled receptors (GPCRs) are sophisticated signaling machines able to simultaneously elicit multiple intracellular signaling pathways upon activation. Complete (in)activation of all pathways can be counterproductive for specific t
Externí odkaz:
https://doaj.org/article/455c7d7ebe814812996e6683dd1c4a42
Autor:
José L. Moreno, Urjita H. Shah, Richard A. Glennon, Javier González-Maeso, Supriya A Gaitonde, Malgorzata Dukat
Publikováno v:
ACS Chemical Neuroscience. 10:2318-2331
Pharmacophore models for 5-HT2A receptor antagonists consist of two aromatic/hydrophobic regions at a given distance from a basic amine. We have previously shown that both aromatic/hydrophobic moieties are unnecessary for binding or antagonist action
Publikováno v:
Current Opinion in Pharmacology. 32:23-31
G protein-coupled receptors (GPCRs) are a remarkably multifaceted family of transmembrane proteins that exert a variety of physiological effects. Although family A GPCRs are able to operate as monomers, there is increasing evidence that heteromerizat
Autor:
Urjita H, Shah, Supriya A, Gaitonde, José L, Moreno, Richard A, Glennon, Małgorzata, Dukat, Javier, González-Maeso
Publikováno v:
ACS chemical neuroscience. 10(5)
Pharmacophore models for 5-HT
Autor:
Kelsey S. Hideshima, Diomedes E. Logothetis, Jose M. Eltit, Jason Younkin, Lia Baki, Amr Ellaithy, Supriya A Gaitonde, Javier González-Maeso, Malgorzata Dukat, José L. Moreno, Rakesh H. Vekariya, Sneha Shah, Richard A. Glennon, Peter Drossopoulos
Publikováno v:
ACS Chemical Neuroscience. 7:1292-1299
Several pharmacophore models have been proposed for 5-HT2A serotonin receptor antagonists. These typically consist of two aromatic/hydrophobic moieties separated by a given distance from each other, and from a basic amine. Although specified distance
Publikováno v:
Cell Chem Biol
G protein-coupled receptors (GPCRs) are critical mediators of cell signaling. Although capable of activating G proteins in a monomeric form, numerous studies reveal a possible association of class A GPCRs into dimers/oligomers. The relative location
Autor:
Yan Jiang, Carolina Muguruza, Daisuke Ibi, Carlos R. Escalante, Maryum K. Ijaz, Daniel J. Christoffel, Schahram Akbarian, Alexey Kozlenkov, Scott J. Russo, Nebojsa Kezunovic, Vishaka Santosh, Jeremy Seto, Javier González-Maeso, Terrell Holloway, Supriya A Gaitonde, Luis F. Callado, J. Javier Meana, Mario de la Fuente Revenga, José L. Moreno, Stella Dracheva, Mitsumasa Kurita, Grace E. Mosley, George W. Huntley, Juan F. López-Giménez, Aintzane García-Bea, Yongchao Ge, Justin M. Saunders
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Ibi, Daisuke et al.
Antipsychotic drugs remain the standard for schizophrenia treatment. Despite their effectiveness in treating hallucinations and delusions, prolonged exposure to antipsychotic medications leads to cognitive deficits in both sc
Antipsychotic drugs remain the standard for schizophrenia treatment. Despite their effectiveness in treating hallucinations and delusions, prolonged exposure to antipsychotic medications leads to cognitive deficits in both sc
Publikováno v:
Carcinogenesis. 22:957-964
Bile acids, principally deoxycholic acid (DCA), have been implicated in the promotion of colon tumorigenesis in both animals and humans. Increasing evidence suggests that bile acids may exert their tumor promoting activity by modulating intracellular
Publikováno v:
Oncogene. 19:4042-4049
P53 is inactivated in tumors by mechanisms other than mutations in the p53 gene itself. To gain insight into the mechanisms by which this inactivation occurs, we chemically mutagenized A1-5 cells expressing high levels of temperature sensitive p53val