Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Supreeth Guptha"'
Autor:
Parvinder Kaur, Santanu Datta, Radha Krishan Shandil, Naveen Kumar, Nanduri Robert, Upneet K Sokhi, Supreeth Guptha, Shridhar Narayanan, Anand Anbarasu, Sudha Ramaiah
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154513 (2016)
One of the major impediments in anti-tubercular drug discovery is the lack of a robust grammar that governs the in-vitro to the in-vivo translation of efficacy. Mycobacterium tuberculosis (Mtb) is capable of growing both extracellular as well as intr
Externí odkaz:
https://doaj.org/article/1ada92cd886d42c2a19139f0d596538e
Autor:
Vijender Panduga, Manoranjan Panda, Radha Shandil, Shridhar Narayanan, Naveen Kumar, M Sreenivasaiah, Monalisa Chatterji, Pravin S. Shirude, Claire Sadler, Vasan K. Sambandamurthy, Tommasi Ruben A, Supreeth Guptha, Jyothi Mahadevaswamy, Meenakshi Mallya, Pravin Iyer, Sreevalli Sharma, Vasanthi Ramachandran, Christopher B. Cooper, Anisha Ambady, Ashwini Narayan, Manjunatha M R, Khisi Mdluli, Scott Butler
Publikováno v:
ACS Med Chem Lett
[Image: see text] We report a novel benzimidazole (BI) based DprE1 inhibitor that resulted from scaffold morphing of a 1,4-azaindole series. The clinical progression of the 1,4-azaindole series from our previous work validates the potential of explor
Autor:
Manoranjan Panda, Anandkumar Raichurkar, Neela Dinesh, Vinayak Hosagrahara, Naveen Kumar, K.R. Prabhakar, Suresh Rudrapatna, Gayathri Balakrishnan, Amit K. Gupta, Vasan K. Sambandamurthy, Karthikeyan Kandaswamy, Stefan Kavanagh, Ramanatha Saralaya, Lalit kumar Jena, Shridhar Narayanan, Suresh Solapure, Robert Nanduri, V. Balasubramanian, Meenakshi Mallya, Ashwini Narayan, Sowmya Bharath, Vijender Panduga, Vikas Shinde, Jitendar Reddy, Khisi Mdluili, Christopher B. Cooper, Parvinder Kaur, Shahul Hameed P, Sreevalli Sharma, Supreeth Guptha, Kakoli Mukherjee, Sudha Ravishankar, Radha Shandil, Pravin Iyer, Shankar D. Markad, Vasanthi Ramachandran, Takahiro Yano, Jyothi Bhat, Harvey Rubin, Subramanyam J. Tantry
Publikováno v:
MedChemComm. 7:1022-1032
The success of bedaquiline as an anti-tubercular agent for the treatment of multidrug-resistant tuberculosis has validated the ATP synthesis pathway and in particular ATP synthase as an attractive target. However, limitations associated with its use
Autor:
Sandesh Jatheendranath, Gayathri Balakrishnan, Sreenivasaiah Menasinakai, Sudha Ravishankar, Vasanthi Ramachandran, Sreevalli Sharma, Charles J. Eyermann, Anisha Ambady, Suresh Rudrapatna, Naina Vinay Mudugal, Disha Awasthy, Umender Sharma, Supreeth Guptha, Vasan K. Sambandamurthy, Radha Nandishaiah, Folkert Reck
Publikováno v:
Tuberculosis. 95:589-598
DNA topoisomerases perform the essential function of maintaining DNA topology in prokaryotes. DNA gyrase, an essential enzyme that introduces negative supercoils, is a clinically validated target. However, topoisomerase I (Topo I), an enzyme responsi
Autor:
Sreevalli Sharma, Monalisa Chatterji, Ashwini Narayan, Sudha Ravishankar, Vasanthi Ramachandran, Vaishali Humnabadkar, Supreeth Guptha, Shahul Hameed, Praveena Manjrekar, Murugan Chinnapattu, K.R. Prabhakar
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:6165-6171
The Mur ligases play an essential role in the biosynthesis of bacterial peptidoglycan and hence are attractive antibacterial targets. A screen of the AstraZeneca compound library led to the identification of compound A, a pyrazolopyrimidine, as a pot
Autor:
Parvinder Kaur, Anisha Ambady, Sreevalli Sharma, Vinayak Hosagrahara, Ashwini Narayan, Vasanthi Ramachandran, Suresh Rudrapatna, Supreeth Guptha, Pravin S. Shirude, Vasan K. Sambandamurthy, Jyothi Mahadevaswamy, Ramachandran Sreekanth A, Kavitha Nagalapur, Anandkumar Raichurkar, Naina Hegde, Manoranjan Panda, Vaishali Humnabadkar
Publikováno v:
Journal of Medicinal Chemistry. 57:4761-4771
A novel pyrazolopyridone class of inhibitors was identified from whole cell screening against Mycobacterium tuberculosis (Mtb). The series exhibits excellent bactericidality in vitro, resulting in a 4 log reduction in colony forming units following c
Autor:
Nilanjana Roy Choudhury, Balachandra Bandodkar, Vasanthi Ramachandran, Ramachandran Sreekanth A, Chaitanya Kumar Kedari, Kakoli Mukerjee, Parvinder Kaur, Manoranjan Panda, Supreeth Guptha, Sreevalli Sharma, Subramanyam J. Tantry
Publikováno v:
ACS Medicinal Chemistry Letters. 5:491-495
A whole cell based screening effort on a focused library from corporate collection resulted in the identification of biarylmethoxy nicotinamides as novel inhibitors of M. tuberculosis (Mtu) H37Rv. The series exhibited tangible structure–activity re
Autor:
Vasanthi Ramachandran, Manoranjan Panda, Vasan K. Sambandamurthy, Subramanyam J. Tantry, Nilanjana Roy Choudhury, Kakoli Mukherjee, Ramachandran Sreekanth A, Supreeth Guptha, Chaitanya Kumar Kedari, Sreevalli Sharma, V. K. Ramya
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:4996-5001
Imidazo[1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead were generated by whole cell screening of a focused library against Mycobacterium tuberculosis. Herein, we describe the synthesis and structure activity relationship evaluation o
Autor:
Claire Sadler, Shubha Sriram, Naina Vinay Mudugal, Boudewijn L. M. de Jonge, Gajanan Shanbhag, David C. McKinney, Praveena Manjrekar, Paul Robert Fleming, Beena Paul, Charles J. Eyermann, Vasan K. Sambandamurthy, Anisha Ambady, Sudha Ravishankar, Parvinder Kaur, Murugan Chinnapattu, Anandkumar Raichurkar, Shahul Hameed P, Chaitanyakumar Kedari, Supreeth Guptha, Manoranjan Panda, Vaishali Humnabadkar
Publikováno v:
ACS chemical biology. 9(10)
The bacterial peptidoglycan biosynthesis pathway provides multiple targets for antibacterials, as proven by the clinical success of β-lactam and glycopeptide classes of antibiotics. The Mur ligases play an essential role in the biosynthesis of the p
Autor:
Eknath Bellale, Maruti Naik, Varun VB, Anisha Ambady, Ashwini Narayan, Sudha Ravishankar, Vasanthi Ramachandran, Parvinder Kaur, Robert McLaughlin, James Whiteaker, Sapna Morayya, Supreeth Guptha, Sreevalli Sharma, Anandkumar Raichurkar, Disha Awasthy, Vijayshree Achar, Prakash Vachaspati, Balachandra Bandodkar, Manoranjan Panda, Monalisa Chatterji
Publikováno v:
Journal of medicinal chemistry. 57(15)
Diarylthiazole (DAT), a hit from diversity screening, was found to have potent antimycobacterial activity against Mycobacterium tuberculosis (Mtb). In a systematic medicinal chemistry exploration, we demonstrated chemical opportunities to optimize th