Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Supratik Dutta"'
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Expression of TEM β-lactamase is a predominant mechanism underlying antibiotic resistance in pathogenic Gram-negative bacteria. Here, the authors use Markov state models to reveal and experimentally confirm hidden conformations that determine TEM su
Externí odkaz:
https://doaj.org/article/234708999b6a401a85bad9993edf6cfe
Publikováno v:
Biophysical Journal. 107(3):613-620
EmrE is a small multidrug resistance transporter that has been well studied as a model for secondary active transport. Because transport requires the protein to convert between at least two states open to opposite sides of the membrane, it is expecte
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications
Nature Communications
TEM β-lactamase confers bacteria with resistance to many antibiotics and rapidly evolves activity against new drugs. However, functional changes are not easily explained by differences in crystal structures. We employ Markov state models to identify
Autor:
Emma A. Morrison, Reza Vafabakhsh, Supratik Dutta, Taekjip Ha, Katherine A. Henzler-Wildman, Dorothee Kern, Arjun Bahl, Gregory T. DeKoster, Michael W. Clarkson
Publikováno v:
Nature
Small multidrug resistance transporters provide an ideal system to study the minimal requirements for active transport. EmrE is one such transporter in Escherichia coli. It exports a broad class of polyaromatic cation substrates, thus conferring resi
Autor:
Raj K. Malla, Benjamin P. Martin, Elena Vasilieva, Cynthia M. Dupureur, Christopher D. Spilling, Supratik Dutta
Cyclipostins are bicyclic lipophilic phosphate natural products. We report here that synthesized individual diastereomers of cyclipostins P and R have nanomolar IC 50 s toward hormone sensitive lipase (HSL). The less potent diastereomers of these com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c71c614ec926ae1f9bb530cc7d30390
https://europepmc.org/articles/PMC4340684/
https://europepmc.org/articles/PMC4340684/
Publikováno v:
Biochimica et biophysica acta. 1838(7)
The small multi-drug resistant (SMR) transporter EmrE functions as a homodimer. Although the small size of EmrE would seem to make it an ideal model system, it can also make it challenging to work with. As a result, a great deal of controversy has su
Autor:
Saibal Bandyopadhyay, Cynthia M. Dupureur, Raj K. Malla, Christopher D. Spilling, Supratik Dutta
Cyclophostin, a structurally unique and potent naturally occurring acetyl cholinesterase (AChE) inhibitor, and its unnatural diastereomer were prepared in 6 steps and 15% overall yield from hydroxymethyl butyrolactone. The unnatural diastereomer of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7fa76a7bc49d09bd7c6ebb810047341
https://europepmc.org/articles/PMC3129627/
https://europepmc.org/articles/PMC3129627/
Autor:
Saibal Bandyopadhyay, Supratik Dutta, Cynthia M. Dupureur, Christopher D. Spilling, Nigam P. Rath
Publikováno v:
The Journal of organic chemistry. 73(21)
Two diastereomers of a phosphonate analog 6 of the AChE inhibitor cyclophostin were synthesized. The substitution reaction of phosphono allylic carbonate 10a with methyl acetoacetate gave the vinyl phosphonate 9a. Attempted hydrogenation/debenzylatio
Autor:
Raj K. Malla, Saibal Bandyopadhyay, Christopher D. Spilling, Supratik Dutta, Cynthia M. Dupureur
Publikováno v:
Organic Letters; Jun2011, Vol. 13 Issue 12, p3094-3097, 4p
Autor:
Supratik Dutta, Greg Dekoster, Katherine A. Henzler-Wildman, Dorothee Kern, Emma A. Morrison, Reza Vafabakhsh, Taekjip Ha, Michael W. Clarkson
Publikováno v:
Biophysical Journal. (3):215a
Small multidrug resistance (SMR) transporters provide an ideal system to study the minimal requirements for active transport across a membrane. EmrE is an E. coli SMR transporter that exports a broad class of polyaromatic cation substrates, thus conf