Výsledky vyhledávání - "Supna Saxena"

Akademický článek

Driving Neuronal Differentiation through Reversal of an ERK1/2-miR-124-SOX9 Axis Abrogates Glioblastoma Aggressiveness

Autor: Hanna Sabelström, Rebecca Petri, Ksenya Shchors, Rahul Jandial, Christin Schmidt, Rohit Sacheva, Selma Masic, Edith Yuan, Trenten Fenster, Michael Martinez, Supna Saxena, Theodore P. Nicolaides, Shirin Ilkhanizadeh, Mitchel S. Berger, Evan Y. Snyder, William A. Weiss, Johan Jakobsson, Anders I. Persson

Publikováno v: Cell Reports, Vol 28, Iss 8, Pp 2064-2079.e11 (2019)

Summary: Identifying cellular programs that drive cancers to be stem-like and treatment resistant is critical to improving outcomes in patients. Here, we demonstrate that constitutive extracellular signal-regulated kinase 1/2 (ERK1/2) activation sust

Externí odkaz: https://doaj.org/article/057d899aad464389833a8cc12ce5d423

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Figure S2 from Antisecretory Factor–Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma

Fig. S2. Interstitial fluid pressure (IFP) pressure sensors do not increase reactive gliosis or microglia activation during tumor progression. (A, B) GFAP+ reactive astrocytes (DAB; brown) and (C, D) Iba1+ tumor-associated macrophages (DAB; brown) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::469f715d35ef062041e132ffa4999561
https://doi.org/10.1158/1541-7786.22513050.v1

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Data from Antisecretory Factor–Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma

Interstitial fluid pressure (IFP) presents a barrier to drug uptake in solid tumors, including the aggressive primary brain tumor glioblastoma (GBM). It remains unclear how fluid dynamics impacts tumor progression and can be targeted therapeutically.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0abd1a8d41cfcedb773f67cfcb00588
https://doi.org/10.1158/1541-7786.c.6540420.v1

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Table S1 from Antisecretory Factor–Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma

Compression-induced changes in the transcriptional GBM phenotype. Differentially expressed genes in tumorspheres derived from human GBMs (GBM5, GBM14, GBM34, and GBM43) when comparing compression to other conditions.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1789986a60b5f0ae643d577602928d1c
https://doi.org/10.1158/1541-7786.22513029.v1

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High density is a property of slow-cycling and treatment-resistant human glioblastoma cells

Autor: Trenten Fenster, Börje Norling, Joanna J. Phillips, Nan Li, Francesca Paterno, Hanna Sabelström, David A. Quigley, Mitchel S. Berger, Supna Saxena, Anders Persson, Edith Yuan, Daniel J. Foster, Clara A.M. Fuchshuber, C. David James

Publikováno v: Experimental Cell Research. 378:76-86

Slow-cycling and treatment-resistant cancer cells escape therapy, providing a rationale for regrowth and recurrence in patients. Much interest has focused on identifying the properties of slow-cycling tumor cells in glioblastoma (GBM), the most commo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0265bc2d1df3674b5e0f2a6df963ce
https://doi.org/10.1016/j.yexcr.2019.03.003

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Antisecretory factor-mediated inhibition of cell volume dynamics produces antitumor activity in glioblastoma

Publikováno v: Molecular cancer research (Online) 16 (2018): 777–790. doi:10.1158/1541-7786.MCR-17-0413
info:cnr-pdr/source/autori:Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley DA, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw JK, Burdick JA, Magnitsky S, Berger MS, Phillips JJ, Arosio D, Sun D, Weaver VM, Weiss WA, Persson AI/titolo:Antisecretory factor-mediated inhibition of cell volume dynamics produces antitumor activity in glioblastoma/doi:10.1158%2F1541-7786.MCR-17-0413/rivista:Molecular cancer research (Online)/anno:2018/pagina_da:777/pagina_a:790/intervallo_pagine:777–790/volume:16
Molecular cancer research : MCR, vol 16, iss 5

Interstitial fluid pressure (IFP) presents a barrier to drug uptake in solid tumors, including the aggressive primary brain tumor glioblastoma multiforme (GBM). It remains unclear how fluid dynamics impacts tumor progression and can be targeted thera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8562a1a297904b86ae6b3f42120db643
http://www.scopus.com/inward/record.url?eid=2-s2.0-85047722544&partnerID=q2rCbXpz

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Cone Vision Changes in the Enhanced S-Cone Syndrome Caused byNR2E3Gene Mutations

Autor: Alan F. Wright, Windy Choi, Alejandro J. Roman, Alexandra V. Garafalo, Supna Saxena, Giacomo Calzetti, Alexander Sumaroka, Artur V. Cideciyan, Samuel G. Jacobson

Publikováno v: Investigative Opthalmology & Visual Science. 59:3209

Purpose To determine the progression of cone vision loss in patients with recessive disease from NR2E3 gene mutations. Methods Patients with NR2E3 mutations (n = 37) were studied as a retrospective observational case series clinically and with chroma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da20c9fc21e6acfef6b1b02778b0386
https://doi.org/10.1167/iovs.18-24518

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EXTH-23. ANTISECRETORY FACTOR-MEDIATED LOWERING OF INTERSTITIAL FLUID PRESSURE PRODUCES ANTI-TUMOR ACTIVITY IN GLIOBLASTOMA

Autor: Daniele Arosio, Aaron Frantz, William A. Weiss, Valerie M. Weaver, Shirin IIkhanizadeh, Dandan Sun, Anders Persson, Janna K. Mouw, Wen Zhu, Edith Yuan, Yekaterina A. Miroshnikova, Sergey Magnitsky, Hanna Sabelström, Mitchel S. Berger, Aurora Irene Idilli, Supna Saxena, Jason A. Burdick, David A. Quigley, Trenten Fenster

Publikováno v: Neuro-Oncology. 19:vi77-vi77

Glioblastoma (GBM) is among the most aggressive cancers. Although high interstitial fluid pressure presents a barrier to drug uptake, how mechanical stresses and osmotic changes impact tumor biology remains unclear. We show that inhibition of the sod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d8c6dbd3680f09a6d5dea5b0535962a
https://doi.org/10.1093/neuonc/nox168.317

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Abstract 1916: Targeting a MAPK-miR-124-Sox9 axis radiosensitizes human glioblastoma cells

Autor: Supna Saxena, Allen Ho, Trenten Fenster, Rahul Jandial, Robyn A. Wong, Ksenya Shchors, Edith Yuan, Theodore Nicolaides, Mitchel H. Berger, Evan Y. Snyder, Johan Jakobsson, Anders Persson, Stanislava Yakovenko, Hanna Sabelström, William A. Weiss, Selma Masic

Publikováno v: Cancer Research. 76:1916-1916

Glioblastoma (GBM) is the most common and aggressive malignant primary brain tumor. Although genetic alterations and overexpression of genes in the RTK/RAS/MEK/ERK pathway (MAPK) is known to drive GBM aggressiveness, less is known about down-stream e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b22b7dc390b9a65e6ea12eb1fd04b40a
https://doi.org/10.1158/1538-7445.am2016-1916

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