Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Suparno, Nandi"'
Autor:
Suparno Nandi, Mishtu Dey
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0282508 (2023)
PKM2 is a rate-limiting enzyme in the glycolytic process and is involved in regulating tumor proliferation. Several amino acids (AAs) such as Asn, Asp, Val, and Cys have been shown to bind to the AA binding pocket of PKM2 and modulate its oligomeric
Externí odkaz:
https://doaj.org/article/a1412b7e15284dd781e410b780050655
Publikováno v:
J Biol Chem
Pyruvate kinase muscle isoform 2 (PKM2) is a key glycolytic enzyme and transcriptional coactivator and is critical for tumor metabolism. In cancer cells, native tetrameric PKM2 is phosphorylated or acetylated, which initiates a switch to a dimeric/mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25e2fe2826716df54c6f2a7cbab18a65
https://doi.org/10.1074/jbc.ra120.015800
https://doi.org/10.1074/jbc.ra120.015800
Autor:
Suparno Nandi, Mishtu Dey
Publikováno v:
J Biol Chem
Pyruvate kinase muscle isoform 2 (PKM2) is a key glycolytic enzyme involved in ATP generation and critical for cancer metabolism. PKM2 is expressed in many human cancers and is regulated by complex mechanisms that promote tumor growth and proliferati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff9b415c5046a786c855ebe2bc966bb3
https://doi.org/10.1074/jbc.ra120.013030
https://doi.org/10.1074/jbc.ra120.013030
Autor:
Zane T, Laughlin, Suparno, Nandi, Debayan, Dey, Natalia, Zelinskaya, Marta A, Witek, Pooja, Srinivas, Ha An, Nguyen, Emily G, Kuiper, Lindsay R, Comstock, Christine M, Dunham, Graeme L, Conn
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(14)
Changes in bacterial ribosomal RNA (rRNA) methylation status can alter the activity of diverse groups of ribosome-targeting antibiotics. These modifications are typically incorporated by a single methyltransferase that acts on one nucleotide target a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::08fd42be2df7e73cd6d00fa51f067dd0
https://pubmed.ncbi.nlm.nih.gov/35357969
https://pubmed.ncbi.nlm.nih.gov/35357969
Autor:
Mishtu Dey, Suparno Nandi
Publikováno v:
PLOS ONE. 18:e0282508
PKM2 is a rate-limiting enzyme in the glycolytic process and is involved in regulating tumor proliferation. Several amino acids (AAs) such as Asn, Asp, Val, and Cys have been shown to bind to the AA binding pocket of PKM2 and modulate its oligomeric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::761925f569434fba91b661b8f8aa63dc
https://doi.org/10.1371/journal.pone.0282508
https://doi.org/10.1371/journal.pone.0282508
Publikováno v:
Biochemistry. 58:3669-3682
Cancer cells regulate key enzymes in the glycolytic pathway to control the glycolytic flux, which is necessary for their growth and proliferation. One of the enzymes is pyruvate kinase muscle isoform 2 (PKM2), which is allosterically regulated by var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514629ffee7d78c0d5ee0a8ff36be965
https://doi.org/10.1021/acs.biochem.9b00349
https://doi.org/10.1021/acs.biochem.9b00349
Autor:
Mishtu Dey, Suparno Nandi
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 75:a406-a406
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb7d8327aa4ad874ff7bf592f8046190
https://doi.org/10.1107/s010876731909603x
https://doi.org/10.1107/s010876731909603x