Výsledky vyhledávání - "Sunny Z. Sun"

Cardiac sodium channel antagonism – Translation of preclinical in vitro assays to clinical QRS prolongation

Autor: Donglin Guo, Bernard Fermini, David S. Ramirez, Stephen Jenkinson, Asser Bassyouni, Jason Cordes, Todd Wisialowski, Sunny Z. Sun, David M. Potter, Jill Steidl-Nichols

Publikováno v: Journal of Pharmacological and Toxicological Methods. 89:9-18

Introduction Cardiac sodium channel antagonists have historically been used to treat cardiac arrhythmias by preventing the reentry of the electrical impulse that could occur following myocardial damage. However, clinical studies have highlighted a si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8af8646dabdbc80e028ae938b088d883
https://doi.org/10.1016/j.vascn.2017.10.002

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L-type calcium channel antagonism – Translation from in vitro to in vivo

Autor: Asser Bassyouni, Sunny Z. Sun, Michelle Hemkens, Bernard Fermini, Todd Wisialowski, David S. Ramirez, Stephen Jenkinson

Publikováno v: Journal of Pharmacological and Toxicological Methods. 84:86-92

Introduction Although therapeutically beneficial in the treatment of certain diseases, L-type calcium channel antagonism can result in unwanted off-target pharmacology leading to adverse drug reactions and to the termination of the development of oth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc60b802e3079ed6b76810c933766e1d
https://doi.org/10.1016/j.vascn.2016.11.002

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Comparative gene expression profiling in human-induced pluripotent stem cell--derived cardiocytes and human and cynomolgus heart tissue

Autor: Bernard Fermini, Dinesh Puppala, Xian Chen, Blake Anson, Sunny Z. Sun, Mathew T. Pletcher, Leon P. Collis, Vinicius Bonato, Sandra J. Engle

Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 131(1)

Cardiotoxicity is one of the leading causes of drug attrition. Current in vitro models insufficiently predict cardiotoxicity, and there is a need for alternative physiologically relevant models. Here we describe the gene expression profile of human-i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50d56cee8f3102a0613e6bb2f703c5f
https://pubmed.ncbi.nlm.nih.gov/22982684

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Pharmacokinetic-pharmacodynamic modelling of the effect of Moxifloxacin on QTc prolongation in telemetered cynomolgus monkeys

Autor: Xian Chen, Bernard Fermini, William P. Gorczyca, Sunny Z. Sun, Mark Holbrook, Ying Zhang, Piet H. van der Graaf, John P. Umland, Kenny J. Watson

Publikováno v: Journal of pharmacological and toxicological methods. 63(3)

Introduction Delayed ventricular repolarisation is manifested electrocardiographically in a prolongation of the QT interval. Such prolongation can lead to potentially fatal Torsades de Pointes. Moxifloxacin is a fluoroquinolone antibiotic which has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a359daa4f5127fc7f3e0f18922d57ba
https://pubmed.ncbi.nlm.nih.gov/21419854

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