Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Sunny Qiu"'
1
Akademický článek
Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes
Autor: Kyoung-in Cho, Dosuk Yoon, Sunny Qiu, Zachary Danziger, Warren M. Grill, William C. Wetsel, Paulo A. Ferreira
Publikováno v: Disease Models & Mechanisms, Vol 10, Iss 5, Pp 559-579 (2017)
The pathogenic drivers of sporadic and familial motor neuron disease (MND), such amyotrophic lateral sclerosis (ALS), are unknown. MND impairs the Ran GTPase cycle, which controls nucleocytoplasmic transport, ribostasis and proteostasis; however, cau
Externí odkaz: https://doaj.org/article/870d58a5967b4d6ea8eef324fdf4e1d6
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2
Akademický článek
Mouse model of rare TOR1A variant found in sporadic focal dystonia impairs domains affected in DYT1 dystonia patients and animal models
Autor: Srishti L. Bhagat, Sunny Qiu, Zachary F. Caffall, Yehong Wan, Yuanji Pan, Ramona M. Rodriguiz, William C. Wetsel, Alexandra Badea, Ute Hochgeschwender, Nicole Calakos
Publikováno v: Neurobiology of Disease, Vol 93, Iss , Pp 137-145 (2016)
Rare de novo mutations in genes associated with inherited Mendelian disorders are potential contributors to sporadic disease. DYT1 dystonia is an autosomal dominant, early-onset, generalized dystonia associated with an in-frame, trinucleotide deletio
Externí odkaz: https://doaj.org/article/1da28a4f412541dabad2ce9a9650e6e6
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3
Akademický článek
Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.
Autor: Kyoung-In Cho, Mdemdadul Haque, Jessica Wang, Minzhong Yu, Ying Hao, Sunny Qiu, Indulekha C L Pillai, Neal S Peachey, Paulo A Ferreira
Publikováno v: PLoS Genetics, Vol 9, Iss 6, p e1003555 (2013)
Non-autonomous cell-death is a cardinal feature of the disintegration of neural networks in neurodegenerative diseases, but the molecular bases of this process are poorly understood. The neural retina comprises a mosaic of rod and cone photoreceptors
Externí odkaz: https://doaj.org/article/1f2e6c69f8544cccaa43c88546ca2746
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4
Radiographic and clinical neurologic manifestations of COVID-19 related hypoxemia
Autor: Caitlin Radnis, Aimee J. Szewka, Sunny Qiu, Miral D. Jhaveri, Ivan Rocha Ferreira da Silva, Lauren Koffman
Publikováno v: Journal of the Neurological Sciences
The novel coronavirus SARS-CoV-2 is known to cause hypoxemia and acute respiratory distress syndrome (ARDS) in a significant portion of those with severe disease. Survivors of critical illness and ARDS often experience neurocognitive impairment but,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::552de275aafa5395bac39a02ea0714f4
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5
Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes
Autor: Paulo Ademar Avelar Ferreira, Zachary C. Danziger, Kyoung-in Cho, Dosuk Yoon, Sunny Qiu, William C. Wetsel, Warren M. Grill
Publikováno v: Disease Models & Mechanisms
Disease Models & Mechanisms, Vol 10, Iss 5, Pp 559-579 (2017)
The pathogenic drivers of sporadic and familial motor neuron disease (MND), such amyotrophic lateral sclerosis (ALS), are unknown. MND impairs the Ran GTPase cycle, which controls nucleocytoplasmic transport, ribostasis and proteostasis; however, cau
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87f3a6090c8e71a7dcc56c0d45d00c6d
http://europepmc.org/articles/PMC5451164
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6
Differential Loss of Prolyl Isomerase or Chaperone Activity of Ran-binding Protein 2 (Ranbp2) Unveils Distinct Physiological Roles of Its Cyclophilin Domain in Proteostasis
Autor: Eugene Senda, Dosuk Yoon, Kyoung In Cho, Paulo Ademar Avelar Ferreira, Minzhong Yu, Sunny Qiu, Andrew Orry, Hemangi Patil, Jessica Wang, Neal S. Peachey, Haiqing Yi
Publikováno v: Journal of Biological Chemistry. 289:4600-4625
The immunophilins, cyclophilins, catalyze peptidyl cis-trans prolyl-isomerization (PPIase), a rate-limiting step in protein folding and a conformational switch in protein function. Cyclophilins are also chaperones. Noncatalytic mutations affecting th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba1651c34858ceac6e59e25c6d9513f
https://doi.org/10.1074/jbc.m113.538215
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