Pharmacodynamics of Ceftriaxone, Ertapenem, Fosfomycin and Gentamicin in Neisseria gonorrhoeae

Autor: Urša Gubenšek, Myrthe de Laat, Sunniva Foerster, Anders Boyd, Alje Pieter van Dam

Publikováno v: Antibiotics, Vol 11, Iss 3, p 299 (2022)

Objectives: To assess the in vitro effect of select antimicrobials on the growth of N. gonorrhoeae and its pharmacodynamic parameters. Methods: Time–kill assays were performed on two reference N. gonorrhoeae strains (ceftriaxone-resistant WHO X and

Externí odkaz: https://doaj.org/article/515e0a7bd38e4e6a90a5f0e586314b5c

Pharmacodynamics of Ceftriaxone, Ertapenem, Fosfomycin and Gentamicin in

Autor: Urša, Gubenšek, Myrthe, de Laat, Sunniva, Foerster, Anders, Boyd, Alje Pieter, van Dam

Publikováno v: Antibiotics (Basel, Switzerland). 11(3)

To assess the in vitro effect of select antimicrobials on the growth ofTime-kill assays were performed on two referenceCeftriaxone, ertapenem and fosfomycin showed gradual death overtime at higher antimicrobial concentrations with a relatively highBa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b671bdb7975acf1aa157302a624b1ac8
https://pubmed.ncbi.nlm.nih.gov/35326763

The first wide-scale drug repurposing screen using the Prestwick Chemical Library (1200 bioactive molecules) against Neisseria gonorrhoeae identifies high in vitro activity of auranofin and many additional drugs

Autor: Sunniva, Foerster, Tomas N, Gustafsson, Anna Rita, Brochado, Valentino, Desilvestro, Athanasios, Typas, Magnus, Unemo

Publikováno v: APMIS : acta pathologica, microbiologica, et immunologica ScandinavicaReferences. 128(3)

Treatment options for gonorrhoea are scarce. Drug repurposing of bioactive molecules approved for other conditions might therefore be of value. We developed a method for wide-scale, systematic drug repurposing screen to identify molecules with activi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::29297ed7dc8699334b56452a8cb60b30
https://pubmed.ncbi.nlm.nih.gov/31811739

In vitro antimicrobial combination testing of and evolution of resistance to the first-in-class spiropyrimidinetrione zoliflodacin combined with six therapeutically relevant antimicrobials for Neisseria gonorrhoeae

Autor: Michael Neely, Laura J. V. Piddock, Magnus Unemo, Daniel Golparian, Emilie Alirol, George L. Drusano, Sunniva Foerster

Publikováno v: The Journal of antimicrobial chemotherapy. 74(12)

ObjectivesResistance in Neisseria gonorrhoeae to all gonorrhoea therapeutic antimicrobials has emerged. Novel therapeutic antimicrobials are imperative and the first-in-class spiropyrimidinetrione zoliflodacin appears promising. Zoliflodacin could be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e81df64997129c42c2aeaa35daac43e
https://pubmed.ncbi.nlm.nih.gov/31730160

Antimicrobial resistance prediction and phylogenetic analysis of Neisseria gonorrhoeae isolates using the Oxford Nanopore MinION sequencer

Autor: Daniel Golparian, Leonor Sánchez-Busó, Simon R. Harris, Magnus Unemo, Sunniva Foerster, Andrea Endimiani, Valentina Donà, Nicola Low

Publikováno v: Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Golparian, Daniel; Donà, Valentina; Sánchez-Busó, Leonor; Foerster, Sunniva; Harris, Simon; Endimiani, Andrea; Low, Nicola; Unemo, Magnus (2018). Antimicrobial resistance prediction and phylogenetic analysis of Neisseria gonorrhoeae isolates using the Oxford Nanopore MinION sequencer. Scientific Reports, 8(1), p. 17596. Nature Publishing Group 10.1038/s41598-018-35750-4

Antimicrobial resistance (AMR) in Neisseria gonorrhoeae is common, compromising gonorrhoea treatment internationally. Rapid characterisation of AMR strains could ensure appropriate and personalised treatment, and support identification and investigat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bb3eb46c9fff78b4cda43d21ce032be
https://pubmed.ncbi.nlm.nih.gov/30514867