Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Sunjoo Ahn"'
Publikováno v:
BMC Neuroscience, Vol 24, Iss 1, Pp 1-11 (2023)
Abstract Background Several phosphodiesterase 4 (PDE4) inhibitors have emerged as potential therapeutics for central nervous system (CNS) diseases. This study investigated the pharmacological effects of two selective PDE4 inhibitors, roflumilast and
Externí odkaz:
https://doaj.org/article/4b7d62c2fa5d4890b4ef50d769a9434b
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 3532-3539 (2023)
Stability of compounds in the human plasma is crucial for maintaining sufficient systemic drug exposure and considered an essential factor in the early stages of drug discovery and development. The rapid degradation of compounds in the plasma can res
Externí odkaz:
https://doaj.org/article/bd4d78c3b6b540fa9bbc02740bd52450
Autor:
Hyosang Kim, Doyoun Kim, Yisul Cho, Kyungdeok Kim, Junyeop Daniel Roh, Yangsik Kim, Esther Yang, Seong Soon Kim, Sunjoo Ahn, Hyun Kim, Hyojin Kang, Yongchul Bae, Eunjoon Kim
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
ARID1B is a chromatin remodeler associated with autism spectrum disorders. Here the authors demonstrate that early postnatal serotonin modulation prevents adult stage deficits in Arid1b-deficient mice through synaptic transcriptional reprogramming.
Externí odkaz:
https://doaj.org/article/4c33d5e79d574c718ca4713148f36998
Autor:
Byungho Lim, Dabin Yoo, Younghwa Chun, Areum Go, Ji Yeon Kim, Ha Young Lee, Rebecca J. Boohaker, Kyung-Jin Cho, Sunjoo Ahn, Jin Soo Lee, DooYoung Jung, Gildon Choi
Publikováno v:
Cancers, Vol 15, Iss 6, p 1737 (2023)
Epigenetic dysregulation characterized by aberrant DNA hypermethylation is a hallmark of cancer, and it can be targeted by hypomethylating agents (HMAs). Recently, we described the superior therapeutic efficacy of a novel HMA, namely, NTX-301, when u
Externí odkaz:
https://doaj.org/article/22825c0e505147f9a7fe7ecf2b501520
Publikováno v:
Nutrients, Vol 14, Iss 22, p 4757 (2022)
Succinic acid is widely used as a food additive, and its effects on sepsis, cancer, ataxia, and obesity were recently reported. Dietary drug exposure studies have been conducted to evaluate the in vivo efficacy of succinic acid, but limited pharmacok
Externí odkaz:
https://doaj.org/article/f9190a329fa549f28fc09d953e06b39e
Autor:
Ha-Young Choi, Bo-Min Kim, Young-Rok Kim, Taehui Yang, Sunjoo Ahn, Dongeun Yong, Jin-Hwan Kwak, Won-Gon Kim
Publikováno v:
Antibiotics, Vol 11, Iss 7, p 902 (2022)
Coralmycins, such as coralmycin A and DH-coralmycin A, have novel molecular skeletons and have been reported to exhibit potent antibacterial activity against standard Gram-positive bacterial strains. Here, the in vitro antibacterial activity against
Externí odkaz:
https://doaj.org/article/b94d319610f647a1a357a99c69d6b892
Autor:
Mihyun Bae, Junyeop Daniel Roh, Youjoung Kim, Seong Soon Kim, Hye Min Han, Esther Yang, Hyojin Kang, Suho Lee, Jin Yong Kim, Ryeonghwa Kang, Hwajin Jung, Taesun Yoo, Hyosang Kim, Doyoun Kim, Heejeong Oh, Sungwook Han, Dayeon Kim, Jinju Han, Yong Chul Bae, Hyun Kim, Sunjoo Ahn, Andrew M Chan, Daeyoup Lee, Jin Woo Kim, Eunjoon Kim
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 2, Pp n/a-n/a (2021)
Abstract Glycine transporters (GlyT1 and GlyT2) that regulate levels of brain glycine, an inhibitory neurotransmitter with co‐agonist activity for NMDA receptors (NMDARs), have been considered to be important targets for the treatment of brain diso
Externí odkaz:
https://doaj.org/article/e7bd2f5e0b814f6d81ea04c17922113e
Encapsulation and Enhanced Delivery of Topoisomerase I Inhibitors in Functionalized Carbon Nanotubes
Autor:
Sieun Chae, Dahee Kim, Kyung-jin Lee, Dasol Lee, Young-O Kim, Yong Chae Jung, Sang Dal Rhee, Kwang Rok Kim, Jeong-O Lee, Sunjoo Ahn, Byumseok Koh
Publikováno v:
ACS Omega, Vol 3, Iss 6, Pp 5938-5945 (2018)
Externí odkaz:
https://doaj.org/article/d00cad212f984af4a59c8b89270e9675
Autor:
Yoo-Kyung Song, Yun-Hwan Seol, Min Ju Kim, Jong-Woo Jeong, Hae-In Choi, Seung-Won Lee, Yoon-Jee Chae, Sunjoo Ahn, Young-Dae Gong, Kyeong-Ryoon Lee, Tae-Sung Koo
Publikováno v:
Pharmaceutics, Vol 13, Iss 3, p 373 (2021)
Supinoxin is a novel anticancer drug candidate targeting the Y593 phospho-p68 RNA helicase, by exhibiting antiproliferative activity and/or suppression of tumor growth. This study aimed to characterize the in vitro and in vivo pharmacokinetics of sup
Externí odkaz:
https://doaj.org/article/dcd06b6dbdef4d99bf9cab27fa2aa6dd
Autor:
Dong-Ho Lee, Joo-Youn Lee, Jieun Jeong, Miok Kim, Kyung Won Lee, Eunseo Jang, Sunjoo Ahn, Chang Hoon Lee, Jong Yeon Hwang
Publikováno v:
Molecules, Vol 22, Iss 11, p 1936 (2017)
Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunosuppressive enzyme that is highly overexpressed in various cancer cells and antigen-presenting cells. It has emerged as an attractive therapeutic target for cancer immunotherapy, which has prompted hig
Externí odkaz:
https://doaj.org/article/4e44d84ce9064c2e81331c77846a7c57