Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sunitha Kandula"'
Autor:
William S. McKechnie, Volkmar Thom, Lukas Kupracz, Jennifer Pollard, Sunitha Kandula, John Welsh
Publikováno v:
Biotechnology Progress. 39
Membrane chromatography has been established as a viable alternative to packed-bed column chromatography for the purification of therapeutic proteins. Purification via membrane chromatography offers key advantages, including higher productivity and r
Publikováno v:
Journal of Pharmaceutical Sciences. 110:1067-1076
Therapeutic manufacturing has become globalized in recent decades, necessitating transportation of drug substance across the world. The outcome of this expansion is significant costs for shipment and added risk of damage to the drug substance contain
Autor:
Lauren Rockwell, Haiying Bao, Francis Insaidoo, Ijeoma Ikechukwu, Nihal Tugcu, Sunitha Kandula
Publikováno v:
Biotechnology progressREFERENCES. 38(3)
Purification of peptides typically includes expensive reverse phase (RP) processes, which utilize high pressure and large volumes of solvent. For two conjugated peptides, chromatography process development targeted a low-pressure aqueous process that
Publikováno v:
Journal of Pharmaceutical Sciences. 106:1944-1951
The storage of drug substance at subzero temperatures mitigates potential risks associated with liquid storage, such as degradation and shipping stress, making it the best solution for long-term storage. However, slower (generally uncontrolled) rates
Autor:
Matthew G. Petroff, Sunitha Kandula, Peter Machielsen, Thomas O. Linden, Haiying Bao, Nihal Tugcu, Miranda van Beuningen – de Vaan, Jennifer M. Pollard, John P. Welsh, David J. Roush
Publikováno v:
Biotechnology and Bioengineering. 113:1273-1283
High throughput experimental strategies are central to the rapid optimization of biologics purification processes. In this work, we extend common high throughput technologies towards the characterization of a multi-column chromatography process for a
Accurate and Rapid Protein Concentration Measurement of In-Process, High Concentration Protein Pools
Publikováno v:
Biotechnology progress. 34(5)
Protein concentration is a critical product quality attribute and required for any therapeutic protein. Many commercial and investigational new biologics are now formulated at high concentrations (>100 mg/ml) to achieve successful subcutaneous admini
Publikováno v:
Biotechnology and Applied Biochemistry. 54:149-155
Protein A chromatography has become widely established for the preparative purification of mAbs (monoclonal antibodies). Low pH elution from Protein A columns followed by neutralization can often lead to precipitation of impurities in the product str
Autor:
Susan Fugett Abu-Absi, Liying Yang, Canping Jiang, Abhinav A. Shukla, Sunitha Kandula, Bernhard M Schilling, Patrick Thompson
Publikováno v:
Biotechnology and bioengineering. 106(6)
The concept of design space has been taking root as a foundation of in-process control strategies for biopharmaceutical manufacturing processes. During mapping of the process design space, the multidimensional combination of operational variables is
Publikováno v:
Biotechnology & Applied Biochemistry; Oct2009, Vol. 54 Issue 3, p149-155, 7p