Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Sunita S Shankaran"'
Autor:
Avi Ma'ayan, Nahid Turan, Bradley L. Demarest, Brent W. Bisgrove, Richard P. Lifton, Zichen Wang, Christine E. Seidman, Alessandro Giardini, Alexander Lachmann, Wendy K. Chung, Richard B. Kim, George A. Porter, Amy E. Roberts, Bruce D. Gelb, Andrew D. Rouillard, Martin Tristani-Firouzi, Sunita S. Shankaran, Deepak Srivastava, Nicolas F. Fernandez, Jonathan J. Edwards, Jane W. Newburger, Martina Brueckner, Elizabeth Goldmuntz, Daniel Bernstein, John E. Deanfield, H. Joseph Yost
Publikováno v:
JACC: Basic to Translational Science
Visual Abstract
Highlights • Combining CHD phenotype–driven gene set enrichment and CRISPR knockdown screening in zebrafish is an effective approach to identifying novel CHD genes. • Mutations affecting genes coding for the WAVE2 protein c
Highlights • Combining CHD phenotype–driven gene set enrichment and CRISPR knockdown screening in zebrafish is an effective approach to identifying novel CHD genes. • Mutations affecting genes coding for the WAVE2 protein c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a00bbf51d3f8f2297e9e92eefd2a0be6
http://europepmc.org/articles/PMC7188873
http://europepmc.org/articles/PMC7188873
Autor:
Shiela C Samson, Tania Ferrer, Chuanchau J Jou, Frank B Sachse, Sunita S Shankaran, Robin M Shaw, Neil C Chi, Martin Tristani-Firouzi, H Joseph Yost
Publikováno v:
PLoS Biology, Vol 11, Iss 12, p e1001727 (2013)
The 3-O-sulfotransferase (3-OST) family catalyzes rare modifications of glycosaminoglycan chains on heparan sulfate proteoglycans, yet their biological functions are largely unknown. Knockdown of 3-OST-7 in zebrafish uncouples cardiac ventricular con
Externí odkaz:
https://doaj.org/article/13b0f2752e574d0fbe47499f334df7c3
Autor:
Martin Tristani-Firouzi, Sunita S. Shankaran, Timothy J. Dahlem, Brent W. Bisgrove, H. Joseph Yost
Publikováno v:
Current Protocols in Molecular Biology
The ability to perform reverse genetics in the zebrafish model organism has been greatly advanced with the advent of the CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated) system. The high level of efficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c038a26b10779e16ddda18dd2394507b
https://doi.org/10.1002/cpmb.42
https://doi.org/10.1002/cpmb.42
Autor:
Robin M. Shaw, Tania Ferrer, Frank B. Sachse, H. Joseph Yost, Sunita S. Shankaran, Shiela C. Samson, Chuanchau J. Jou, Neil C. Chi, Martin Tristani-Firouzi
Publikováno v:
PLoS Biology
PLoS biology, vol 11, iss 12
PLoS Biology, Vol 11, Iss 12, p e1001727 (2013)
PLoS biology, vol 11, iss 12
PLoS Biology, Vol 11, Iss 12, p e1001727 (2013)
During zebrafish cardiac development, 3-OST-7 constrains BMP signaling to the atrioventricular junction and precludes it from contractile myocardium, allowing tropomyosin-dependent sarcomere assembly and contraction.
The 3-O-sulfotransferase (3-
The 3-O-sulfotransferase (3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad02e95bea88ec7677f635d3e3776d95
https://pubmed.ncbi.nlm.nih.gov/24311987
https://pubmed.ncbi.nlm.nih.gov/24311987
Publikováno v:
Methods in Molecular Biology ISBN: 9781627030557
Real-time imaging coupled with a permeabilized cell system presents a very versatile platform to visualize the dynamic and intricate nature of nuclear envelope breakdown, one of the major morphological changes of mitosis. Here, we describe such a str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b5d86cf355551c0330fdd1dedaac680
https://europepmc.org/articles/PMC4366132/
https://europepmc.org/articles/PMC4366132/
Publikováno v:
Zebrafish. 13:S-66
By most measures, the University of Utah Centralized Zebrafish Animal Resource is a successful zebrafish core facility: we house ∼4000-5000 tanks for over 16 research groups; provide services and equipment for ∼150 users; are currently undergoing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1eaa177c1da0daab7953ffadfe585621
https://doi.org/10.1089/zeb.2015.1207
https://doi.org/10.1089/zeb.2015.1207
Autor:
Katharine S. Ullman, Stephen A. Adam, Douglas R. Mackay, Sunita S. Shankaran, Masaki Makise, Suzanne Elgort
Interactions between Nup50 and soluble transport factors underlie the efficiency of certain nucleocytoplasmic transport pathways. The platform on which these interactions take place is important to building a complete understanding of nucleocytoplasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a5439fb716c8ad73a0f9b2ff4d9f8f
https://europepmc.org/articles/PMC3493896/
https://europepmc.org/articles/PMC3493896/
Autor:
Takashi Matsuwaki, Christian Haass, Aaron Carlson, Ramona Rodde, Anja Capell, Masugi Nishihara, Dorothee Dormann, Sunita S. Shankaran, Manuela Neumann, Keitaro Yamanouchi, Elisabeth Kremmer
Publikováno v:
Europe PubMed Central
Journal of neurochemistry 110(3), 1082-1094 (2009). doi:10.1111/j.1471-4159.2009.06211.x
Journal of neurochemistry 110(3), 1082-1094 (2009). doi:10.1111/j.1471-4159.2009.06211.x
Neuronal and glial deposition of misfolded, proteolytically processed, polyubiquitinated and abnormally phosphorylated C-terminal fragments (CTFs) of the TAR DNA binding protein-43 (TDP-43) is a pathological hallmark of frontotemporal lobar degenerat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fe215b07fd13b33afda76cd18b047b6
Autor:
Katrin Fellerer, Manuela Neumann, Alexander Hruscha, Sunita S. Shankaran, Christian Haass, Bettina Schmid, Anja Capell
Publikováno v:
The Journal of biological chemistry. 283(3)
Loss of function mutations in progranulin cause tau-negative frontotemporal lobar degeneration with ubiquitin-positive inclusions. A major protein component of these inclusions is TDP-43, which becomes hyperphosphorylated, ubiquitinated, and cleaved
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9044fb98ba7fabaf76322b9334c0f843
https://pubmed.ncbi.nlm.nih.gov/17984093
https://pubmed.ncbi.nlm.nih.gov/17984093
Autor:
Dirk Sieger, Thomas Becker, Marie-Christin Pauly, Christian Schröter, Andrew C. Oates, Martin Gajewski, Sunita S. Shankaran, Mary Laplante, Carmen Czepe
Publikováno v:
Developmental biology. 304(2)
Somitogenesis is the key developmental process that lays down the framework for a metameric body in vertebrates. Somites are generated from the un-segmented presomitic mesoderm (PSM) by a pre-patterning process driven by a molecular oscillator termed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b7a51f6926004ff7dbdbc35b428735
https://pubmed.ncbi.nlm.nih.gov/17274976
https://pubmed.ncbi.nlm.nih.gov/17274976