Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sunilima Sinha"'
Autor:
Olga V Glinskii, Vladislav V Glinsky, Leike Xie, Filiz Bunyak, Vladimir V Glinskii, Sunilima Sinha, Suneel Gupta, Renato V Iozzo, Rajiv R Mohan
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284082 (2023)
The cornea and cranial dura mater share sensory innervation. This link raises the possibility that pathological impulses mediated by corneal injury may be transmitted to the cranial dura, trigger dural perivascular/connective tissue nociceptor respon
Externí odkaz:
https://doaj.org/article/4b7246b2c1ed4c90a466d93014bbda0f
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18771 (2011)
Untargeted and uncontrolled gene delivery is a major cause of gene therapy failure. This study aimed to define efficient and safe tissue-selective targeted gene therapy approaches for delivering genes into keratocytes of the cornea in vivo using a no
Externí odkaz:
https://doaj.org/article/2ef7b76fbe4944e39639800beb7ab4ae
Publikováno v:
The FASEB Journal. 35
Autor:
R. Michael Roberts, Toshihiko Ezashi, Sunilima Sinha, Shrikesh Sachdev, Bhanu Prakash V.L. Telugu, Andrei P. Alexenko
Publikováno v:
Proceedings of the National Academy of Sciences. 106:10993-10998
For reasons that are unclear the production of embryonic stem cells from ungulates has proved elusive. Here, we describe induced pluripotent stem cells (iPSC) derived from porcine fetal fibroblasts by lentiviral transduction of 4 human (h) genes, h O
Publikováno v:
Progress in Retinal and Eye Research. 24:537-559
Technological advances in the field of gene therapy has prompted more than three hundred phase I and phase II gene-based clinical trials for the treatment of cancer, AIDS, macular degeneration, cardiovascular, and other monogenic diseases. Besides tr
Autor:
Katsuyuki Adachi, Andrei P. Alexenko, Mitsuyoshi Amita, Sunilima Sinha, Toshihiko Ezashi, Laura C. Schulz, Danny J. Schust, R. Michael Roberts
Publikováno v:
Proceedings of the National Academy of Sciences. 110
Human ES cells (hESC) exposed to bone morphogenic protein 4 (BMP4) in the absence of FGF2 have become widely used for studying trophoblast development, but the soundness of this model has been challenged by others, who concluded that differentiation
Autor:
Andrei P. Alexenko, Randall S. Prather, Toshihiko Ezashi, Lee D. Spate, Bhanu Prakash V.L. Telugu, Sunilima Sinha, R. Michael Roberts
Publikováno v:
The Journal of Biological Chemistry
The pig is important for agriculture and as an animal model in human and veterinary medicine, yet despite over 20 years of effort, there has been a failure to generate pluripotent stem cells analogous to those derived from mouse embryos. Here we repo
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e18771 (2011)
PLoS ONE
PLoS ONE
Untargeted and uncontrolled gene delivery is a major cause of gene therapy failure. This study aimed to define efficient and safe tissue-selective targeted gene therapy approaches for delivering genes into keratocytes of the cornea in vivo using a no
Decorin, a small leucine-rich proteoglycan, is a natural inhibitor of transforming growth factor beta (TGFbeta). Myofibroblast and haze formation in the cornea have been attributed to TGFbeta hyperactivity released from corneal epithelium following i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33035b772a2019e1f6c64187f0c6421b
https://europepmc.org/articles/PMC2929567/
https://europepmc.org/articles/PMC2929567/
Publikováno v:
Investigative ophthalmologyvisual science. 50(6)
Trichostatin A (TSA), a histone deacetylase inhibitor, has been shown to suppress TGF-beta-induced fibrogenesis in many nonocular tissues. The authors evaluated TSA cytotoxicity and its antifibrogenic activity on TGF-beta-driven fibrosis in the corne