Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sunil Sud"'
Autor:
Shashank Gupta, Iteash Agarwal, Vijayalaxmi Mogiligidda, Rajesh Kumar Krishnan, Sruthi Chennuri, Deepika Aggarwal, Anwesha Hoodati, Sheroy Cooper, Ranjan, Mohammad Bilal Sheik, K. M. Bhavya, Manasa Hegde, M. Naveen Krishna, Amit Kumar Chauhan, Mallikarjun Korrapati, Sumit Singh, J. B. Singh, Sunil Sud, Sunil Gupta, Sidhartha Pant, Sankar, Neha Agrawal, Ashish Ranjan, Piyush Mohapatra, T. Roopak, Arsh Ahmad, M. Nanjunda, Dilip Singh
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Major research interests on quantum key distribution (QKD) are primarily focused on increasing 1. Point-to-point transmission distance (1000 km). 2. Secure key rate (Mbps). 3. Security of quantum layer (device-independence). It is great to p
Externí odkaz:
https://doaj.org/article/e821c27b9d254d549a2f829cb9aefc78
Autor:
Nader H. Mahmoudzadeh, Yasaman Heidarian, Jason P. Tourigny, Alexander J. Fitt, Katherine Beebe, Hongde Li, Arthur Luhur, Kasun Buddika, Liam Mungcal, Anirban Kundu, Robert A. Policastro, Garrett J. Brinkley, Gabriel E. Zentner, Travis Nemkov, Robert Pepin, Geetanjali Chawla, Sunil Sudarshan, Aylin R. Rodan, Angelo D'Alessandro, Jason M. Tennessen
Publikováno v:
Molecular Metabolism, Vol 89, Iss , Pp 102013- (2024)
Objectives: The mitochondrial enzyme L-2-hydroxyglutarate dehydrogenase (L2HGDH) regulates the abundance of L-2-hydroxyglutarate (L-2HG), a potent signaling metabolite capable of influencing chromatin architecture, mitochondrial metabolism, and cell
Externí odkaz:
https://doaj.org/article/c959551a1a6c44d4a4238d794febab0c
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
2-Hydroxyglutarate (2HG) overproducing tumors arise in a number of tissues, including the kidney. The tumorigenesis resulting from overproduced 2HG has been attributed to the ability of 2HG alter gene expression by inhibiting α-ketoglutarate (αKG)-
Externí odkaz:
https://doaj.org/article/8d1aef0720614c62a226994c1a467a98
Autor:
Andrew M Fang, Samuel J Galgano, Jennifer B Gordetsky, Sunil Sudarshan, Andrew M McDonald, Soroush Rais-Bahrami
Publikováno v:
Urology Annals, Vol 12, Iss 2, Pp 172-175 (2020)
Prostate cancer is the most common noncutaneous malignancy in American men. Its lymphatic drainage is very well established throughout literature. We report the case of a 72-year-old Caucasian male with elevated serum prostate-specific antigen and bi
Externí odkaz:
https://doaj.org/article/b53beaac8930419bbadfefb618a31889
Autor:
Hyeyoung Nam, Anirban Kundu, Suman Karki, Garrett J. Brinkley, Darshan S. Chandrashekar, Richard L. Kirkman, Juan Liu, Maria V. Liberti, Jason W. Locasale, Tanecia Mitchell, Sooryanarayana Varambally, Sunil Sudarshan
Publikováno v:
JCI Insight, Vol 6, Iss 22 (2021)
Mounting evidence points to alterations in mitochondrial metabolism in renal cell carcinoma (RCC). However, the mechanisms that regulate the TCA cycle in RCC remain uncharacterized. Here, we demonstrate that loss of TCA cycle enzyme expression is ret
Externí odkaz:
https://doaj.org/article/eb7183e5d0134cfe9561270e096c17b2
Autor:
Garrett Brinkley, Hyeyoung Nam, Eunhee Shim, Richard Kirkman, Anirban Kundu, Suman Karki, Yasaman Heidarian, Jason M. Tennessen, Juan Liu, Jason W. Locasale, Tao Guo, Shi Wei, Jennifer Gordetsky, Teresa L. Johnson-Pais, Devin Absher, Dinesh Rakheja, Anil K. Challa, Sunil Sudarshan
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 11 (2020)
L-2-hydroxyglutarate (L-2HG) is an oncometabolite found elevated in renal tumors. However, this molecule might have physiological roles that extend beyond its association with cancer, as L-2HG levels are elevated in response to hypoxia and during Dro
Externí odkaz:
https://doaj.org/article/6dd4f46ccd38444ea52f902f75ef43e0
Autor:
Pooja Ghatalia, Eddy S Yang, Brittany N Lasseigne, Ryne C Ramaker, Sara J Cooper, Dongquan Chen, Sunil Sudarshan, Shi Wei, Arjun S Guru, Amy Zhao, Tiffiny Cooper, Deborah L Della Manna, Gurudatta Naik, Richard M Myers, Guru Sonpavde
Publikováno v:
PLoS ONE, Vol 11, Iss 8, p e0160924 (2016)
Kinases are therapeutically actionable targets. Kinase inhibitors targeting vascular endothelial growth factor receptors (VEGFR) and mammalian target of rapamycin (mTOR) improve outcomes in metastatic clear cell renal cell carcinoma (ccRCC), but are
Externí odkaz:
https://doaj.org/article/4965e5d1648948e38899faaafc8f39cd
Autor:
Joshua C Anderson, Christopher D Willey, Amitkumar Mehta, Karim Welaya, Dongquan Chen, Christine W Duarte, Pooja Ghatalia, Waleed Arafat, Ankit Madan, Sunil Sudarshan, Gurudatta Naik, William E Grizzle, Toni K Choueiri, Guru Sonpavde
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0139267 (2015)
Despite the widespread use of kinase-targeted agents in clear cell renal cell carcinoma (CC-RCC), comprehensive kinase activity evaluation (kinomic profiling) of these tumors is lacking. Thus, kinomic profiling of CC-RCC may assist in devising a clas
Externí odkaz:
https://doaj.org/article/808d0e821cff4e1e97f8403c1ebd8bd9
Autor:
John P Fitzgerald, Bijaya Nayak, Karthigayan Shanmugasundaram, William Friedrichs, Sunil Sudarshan, Assaad A Eid, Thomas DeNapoli, Dipen J Parekh, Yves Gorin, Karen Block
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e30712 (2012)
Inflammatory cytokines are detected in the plasma of patients with renal cell carcinoma (RCC) and are associated with poor prognosis. However, the primary cell type involved in producing inflammatory cytokines and the biological significance in RCC r
Externí odkaz:
https://doaj.org/article/f966c6a97bb24d6f9387878eec669568
Autor:
Sunil Sudarshan, Karthigayan Shanmugasundaram, Susan L Naylor, Shu Lin, Carolina B Livi, Christine F O'Neill, Dipen J Parekh, I-Tien Yeh, Lu-Zhe Sun, Karen Block
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21037 (2011)
Germline mutations of FH, the gene that encodes for the tricarboxylic acid TCA (TCA) cycle enzyme fumarate hydratase, are associated with an inherited form of cancer referred to as Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC). Individuals
Externí odkaz:
https://doaj.org/article/afe678de0b564340818bc772790d6cab