Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sunil Sarda"'
Autor:
Claudio Avila, Carlo Cassani, Thierry Kogej, Javier Mazuela, Sunil Sarda, Adam D. Clayton, Michael Kossenjans, Clive P. Green, Richard A. Bourne
Publikováno v:
Chemical Science. 13:12087-12099
For the discovery of new candidate molecules in the pharmaceutical industry, library synthesis is a critical step, in which library size, diversity, and time to synthesise are fundamental. In this work we propose stopped-flow synthesis as an intermed
Publikováno v:
Drug discovery today. 26(1)
Faced with ageing infrastructure and ever-increasing demands from hit discovery and lead optimisation functions, AstraZeneca has chosen to develop innovative technologies and process solutions to support the future of drug discovery. These include th
Autor:
Jonathan Wills, Ian D. Wilson, Alan McCarthy, Huw B. Jones, Chris Page, Kerry Ratcliffe, Sunil Sarda, Tim Schulz-Utermoehl, Kathryn Pickup, Alison V. M. Rodrigues, Elizabeth A. Partridge, Scott W. Martin
Publikováno v:
Archives of Toxicology. 91:2643-2653
The distribution, metabolism, excretion and hepatic effects of the human hepatotoxin fenclozic acid were investigated following single oral doses of 10 mg/kg to normal and bile duct-cannulated male C57BL/6J mice. Whole body autoradiography showed dis
Autor:
Dong Guo, Ian L. Dale, Robert J. Sheppard, Wesley Keur, Sunil Sarda, Michael J. Waring, Adriaan P. IJzerman, J. Daniel Hothersall, Philip B. Rawlins, Hongming Chen, Stephen J. Hill
Publikováno v:
Molecular Pharmacology
Molecular Pharmacology, 91(1), 25-38. AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
Molecular Pharmacology, 91(1), 25-38. AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
The duration of action of adenosine A(2A) receptor (A2A) agonists is critical for their clinical efficacy, and we sought to better understand how this can be optimized. The in vitro temporal response profiles of a panel of A2A agonists were studied u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca8f8150d2798d617f7e594848bab48
https://nottingham-repository.worktribe.com/file/830700/1/25.full.pdf
https://nottingham-repository.worktribe.com/file/830700/1/25.full.pdf
Autor:
Darren Wilbraham, Sunil Sarda, Helen Swaisland, Michael D. Malone, Serban Ghiorghiu, Peter Ballard
Publikováno v:
Xenobiotica. 44:1083-1098
1. This series of studies in rats, dogs and humans (Clinicaltrials.gov identifier: NCT01284595) investigated the pharmacokinetics, tissue distribution, metabolism and excretion of the EGFR, HER2 and HER3 signalling inhibitor AZD8931. 2. Single oral o
Autor:
John R. Foster, Anna Abrahamsson, Kevin J. Randall, Kathryn Pickup, Lars Weidolf, Kristin Samuelsson, Matt Jacobsen, Sunil Sarda, Ian D. Wilson
Publikováno v:
Xenobiotica. 44:186-195
1. The biotransformation, hepatic transporter and blood chemistry effects of troglitazone were investigated following 7 days of dosing at 600 mg/kg/day to chimeric murinized or humanized FRG mice, Mo-FRG and Hu-FRG mice, respectively. 2. Clinical che
Autor:
Kathryn, Pickup, Scott, Martin, Elizabeth A, Partridge, Huw B, Jones, Jonathan, Wills, Tim, Schulz-Utermoehl, Alan, McCarthy, Alison, Rodrigues, Chris, Page, Kerry, Ratcliffe, Sunil, Sarda, Ian D, Wilson
Publikováno v:
Archives of Toxicology
The distribution, metabolism, excretion and hepatic effects of the human hepatotoxin fenclozic acid were investigated following single oral doses of 10 mg/kg to normal and bile duct-cannulated male C57BL/6J mice. Whole body autoradiography showed dis
Autor:
Huw B. Jones, Sunil Sarda, Jonathan Wills, Scott W. Martin, Kathryn Pickup, Alison V. M. Rodrigues, Ian D. Wilson, Chris Page
Publikováno v:
Xenobiotica. 44:164-173
1. The distribution, metabolism, excretion and hepatic effects of fenclozic acid were investigated following a single oral dose of 10 mg/kg to hepatic reductase null (HRN) mice. 2. The majority of the [(14)C]-fenclozic acid was eliminated via the uri
Publikováno v:
Chromatographia. 77:233-239
Biliary metabolites present at 6 h post-dose following a single oral dose of [14C]-diclofenac (10 mg kg−1) to male bile duct-cannulated C57BL/6 J mice were profiled and identified. Over the 6 h duration of the study ~19.5 % of the administered radi
Autor:
Hans V. Westerhoff, J. Gerry Kenna, Jacky L. Snoep, Franco B. du Preez, Suzanne Geenen, Sunil Sarda, Ian D. Wilson, Alison J. Foster
Publikováno v:
Biochimica et Biophysica Acta G General Subjects, 1830(10), 4943-59. Elsevier
Biochimica et Biophysica Acta (BBA)-General Subjects, 1830, 4943-4959. Elsevier
Geenen, S, du Preez, F B, Snoep, J L, Foster, A J, Sarda, S, Kenna, J G, Wilson, I D & Westerhoff, H V 2013, ' Glutathione metabolism modelling: a mechanism for liver drug-robustness and a new biomarker strategy ', Biochimica et Biophysica Acta (BBA)-General Subjects, vol. 1830, pp. 4943-4959 . https://doi.org/10.1016/j.bbagen.2013.04.014
Biochimica et Biophysica Acta (BBA)-General Subjects, 1830, 4943-4959. Elsevier
Geenen, S, du Preez, F B, Snoep, J L, Foster, A J, Sarda, S, Kenna, J G, Wilson, I D & Westerhoff, H V 2013, ' Glutathione metabolism modelling: a mechanism for liver drug-robustness and a new biomarker strategy ', Biochimica et Biophysica Acta (BBA)-General Subjects, vol. 1830, pp. 4943-4959 . https://doi.org/10.1016/j.bbagen.2013.04.014
Background Glutathione metabolism can determine an individual's ability to detoxify drugs. To increase understanding of the dynamics of cellular glutathione homeostasis, we have developed an experiment-based mathematical model of the kinetics of the