Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sunil Sabbani"'
Autor:
Paul M. O’Neill, Richard K. Amewu, Susan A. Charman, Sunil Sabbani, Nina F. Gnädig, Judith Straimer, David A. Fidock, Emma R. Shore, Natalie L. Roberts, Michael H.-L. Wong, W. David Hong, Chandrakala Pidathala, Chris Riley, Ben Murphy, Ghaith Aljayyoussi, Francisco Javier Gamo, Laura Sanz, Janneth Rodrigues, Carolina Gonzalez Cortes, Esperanza Herreros, Iñigo Angulo-Barturén, María Belén Jiménez-Díaz, Santiago Ferrer Bazaga, María Santos Martínez-Martínez, Brice Campo, Raman Sharma, Eileen Ryan, David M. Shackleford, Simon Campbell, Dennis A. Smith, Grennady Wirjanata, Rintis Noviyanti, Ric N. Price, Jutta Marfurt, Michael J. Palmer, Ian M. Copple, Amy E. Mercer, Andrea Ruecker, Michael J. Delves, Robert E. Sinden, Peter Siegl, Jill Davies, Rosemary Rochford, Clemens H. M. Kocken, Anne-Marie Zeeman, Gemma L. Nixon, Giancarlo A. Biagini, Stephen A. Ward
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Artemisinin-resistantPlasmodium is an increasing problem. Here, using a medicinal chemistry programme, the authors identify a tetraoxane-based drug candidate that shows no cross-resistance with an artemisinin-resistant strain (PfK13-C580Y) and is eff
Externí odkaz:
https://doaj.org/article/d0b09995908d4fd1a466aa398f702f2f
Autor:
Sunil Sabbani, Jill Davies, Paul McGillan, Paul O´Neill, Ben Murphy, Richard Amewu, Matthew J. Schnaderbeck, Christopher Riley, Gemma L. Nixon, Emma R. Shore, Stephen A. Ward, Natalie L. Roberts
Publikováno v:
TETRAHEDRON
An efficient route to the synthesis of potent antimalarial aryloxy 1,2,4,5-tetraoxanes is described that permits parallel synthesis for Structure–Activity Relationship (SAR) investigations. Brief details of the in vitro and in vivo antimalarial eva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::337eaa4e4c10df82d7e094e6379091d5
https://doi.org/10.1016/j.tet.2016.08.043
https://doi.org/10.1016/j.tet.2016.08.043
Autor:
Emiliano Mancini, Giuseppe M. Carpaneto, Agnese Zauli, Marco Alberto Bologna, Paolo Audisio, Erik Hedenström, Federico Romiti, Glenn P. Svensson, Lara Redolfi De Zan, Stefano Chiari, Franklin N. Nyabuga, Sunil Sabbani
Resolving complexes of closely related and cryptic insect species can be challenging, especially when dealing with rare and protected taxa that are difficult to collect for genetic and morphological analyses. Until recently, populations of the genus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6a975d6c3137147c85aebc49ba7fc05
http://hdl.handle.net/11573/958178
http://hdl.handle.net/11573/958178
Autor:
Sunil Sabbani, Paul M. O'Neill, J. Luis Castrejon, Ayman Elsheikh, James L. Maggs, Dean J. Naisbitt, Sidonie N. Lavergne, B. Kevin Park, John Farrell
Publikováno v:
Chemical Research in Toxicology. 23:184-192
Exposure to sulfamethoxazole (SMX) is associated with T-cell-mediated hypersensitivity reactions in human patients. T-cells can be stimulated by the putative metabolite nitroso SMX, which binds irreversibly to protein. The hydroxylamine and nitroso d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0b5cd2fc660b33eee2b4a779c8d3011
https://doi.org/10.1021/tx900329b
https://doi.org/10.1021/tx900329b
Publikováno v:
Tetrahedron. 65:8531-8537
A series of antimalarial chiral 1,2,4-trioxanes (1–8) were synthesised in high enantiomeric purities. Enantioselective addition of R2Zn reagent to 3-methyl-2-butenal catalysed by (+)-MIB or (−)-MIB yielded both the enantiomers of the chiral allyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6090651a2ea9b4c837f65871423ed44b
https://doi.org/10.1016/j.tet.2009.08.020
https://doi.org/10.1016/j.tet.2009.08.020
Autor:
Sunil Sabbani, Erik Hedenström
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 58:6-9
Candida rugosa lipase (CRL) catalysed enantioselective esterification of racemic 2-methylhexanoic acid was performed with 1-decanol in organic solvent at constant water activity (aw). The aw was maintained either by a salt hydrate pair added in the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c97c310b55aede7066cb7f49a94c9c97
https://doi.org/10.1016/j.molcatb.2008.10.010
https://doi.org/10.1016/j.molcatb.2008.10.010
Autor:
Jill Davies, Sunil Sabbani, Erik Hedenström, Paul A. Stocks, Gemma L. Ellis, Paul M. O'Neill, Stephen A. Ward
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5804-5808
Dispiro N-Boc-protected 1,2,4-trioxane 2 was synthesised via Mo(acac)(2) catalysed perhydrolysis of N-Boc spirooxirane followed by condensation of the resulting beta-hydroperoxy alcohol 10 with 2-adamantanone. N-Boc 1,2,4-trioxane 2 was converted to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944422053a48d3a95bb5272f30b4bb6f
https://doi.org/10.1016/j.bmcl.2008.09.052
https://doi.org/10.1016/j.bmcl.2008.09.052
Autor:
María Jesús, Gemma L. Ellis, Livia Vivas, Jill Davies, Emily Bongard, Alison E. Shone, Domingo Gargallo, Sarah C. Charnaud, Karen Rimmer, Richard Amewu, Paul M. O'Neill, Sunil Sabbani, Deborah Stanford, Peter Gibbons, Stephen A. Ward, Paul A. Stocks, Sonia Lozanom, Charlotte Hall
Publikováno v:
Journal of Medicinal Chemistry. 51:2170-2177
A rapid, two-step synthesis of a range of dispiro-1,2,4,5-tetraoxanes with potent antimalarial activity both in vitro and in vivo has been achieved. These 1,2,4,5-tetraoxanes have been proven to be superior to 1,2,4-trioxolanes in terms of stability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::030b9ed2f11ed04356cc9e1c48588770
https://doi.org/10.1021/jm701435h
https://doi.org/10.1021/jm701435h
Publikováno v:
Tetrahedron: Asymmetry. 18:1712-1720
Enantioselective acylation of some (±)-3-alkyl-3-phenyl-1-propanols was performed with enzymes as catalysts. Moderate enantiomeric ratios ( E ), ranging up to E = 11.6, were obtained. In the resolution, some of the lipases selectively acylated the (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ea22476c4470fad6745ea6e90962785
https://doi.org/10.1016/j.tetasy.2007.07.002
https://doi.org/10.1016/j.tetasy.2007.07.002
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 42:1-9
When Candida rugosa lipase (CRL) was immobilised on the porous polypropylene carrier Accurel it was found that differences in the samples of the carrier influenced the enantiomeric ratio (E) when racemic 2-methylhexanoic acid was esterified with 1-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed6d66e47f3af2d43d092945b19bd859
https://doi.org/10.1016/j.molcatb.2006.05.003
https://doi.org/10.1016/j.molcatb.2006.05.003