Zobrazeno 1 - 10
of 388
pro vyhledávání: '"Sunil SINGHAL"'
Autor:
Patrick Bou-Samra, MD, Austin Chang, BA, Emily Guo, BA, Feredun Azari, MD, Gregory Kennedy, MD, Azra Din, MPH, Taine Pechet, MD, Doraid Jarrar, MD, John Kucharczuk, MD, Jarrod Predina, MD, James Delikatny, PhD, Philip S. Low, PhD, Sunil Singhal, MD
Publikováno v:
Annals of Thoracic Surgery Short Reports, Vol 2, Iss 3, Pp 432-437 (2024)
Background: Intraoperative molecular imaging (IMI) uses a cancer-targeted fluorescent agent injected into patients to localize tumor nodules. Pafolacianine is a folate receptor (FR)–targeted near-infrared fluorescent probe. Almost 10% of patients h
Externí odkaz:
https://doaj.org/article/4dd803d4e4eb4522b467f59e997dc021
Autor:
Michael C. Hart, Ritesh K. Isuri, Drew Ramos, Sofya A. Osharovich, Andrea E. Rodriguez, Stefan Harmsen, Grace C. Dudek, Jennifer L. Huck, David E. Holt, Anatoliy V. Popov, Sunil Singhal, Edward J. Delikatny
Publikováno v:
Chemical & Biomedical Imaging, Vol 2, Iss 7, Pp 490-500 (2024)
Externí odkaz:
https://doaj.org/article/2283b801ebeb49d7bbea0989952d9563
Autor:
Sumita Trivedi, Caitlin Tilsed, Maria Liousia, Robert M. Brody, Karthik Rajasekaran, Sunil Singhal, Steven M. Albelda, Astero Klampatsa
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract With cancer immunotherapy and precision medicine dynamically evolving, there is greater need for pre-clinical models that can better replicate the intact tumor and its complex tumor microenvironment (TME). Precision-cut tumor slices (PCTS) h
Externí odkaz:
https://doaj.org/article/6e7812809ba14842928fa6342c728aad
Autor:
Tatiana Akimova, Liqing Wang, Zhanna Bartosh, Lanette M. Christensen, Evgeniy Eruslanov, Sunil Singhal, Veenu Aishwarya, Wayne W. Hancock
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Our goal is to improve the outcomes of cancer immunotherapy by targeting FOXP3+ T-regulatory (Treg) cells with a next generation of antisense oligonucleotides (ASO), termed FOXP3 AUMsilence ASO. We performed in vitro experiments with human healthy do
Externí odkaz:
https://doaj.org/article/a96f23f9055b414882bcdbc8711caf2b
Autor:
Patrick Bou‐Samra, Austin Chang, Kevin Zhang, Feredun Azari, Gregory Kennedy, Emily Guo, Wei‐Ting Hwang, Sunil Singhal
Publikováno v:
Thoracic Cancer, Vol 14, Iss 27, Pp 2770-2776 (2023)
Abstract Background Pleurectomy and decortication (PD) in malignant pleural mesothelioma has a high morbidity mostly associated with aspiration pneumonia (PNA), deep vein thrombosis (DVT), and foreign catheter sepsis. We instituted four strategies to
Externí odkaz:
https://doaj.org/article/9403979138764f269c2b2f2c214d0600
Autor:
Patrick Bou‐Samra, Austin Chang, Feredun Azari, Gregory Kennedy, Alix Segil, Emily Guo, Melina Marmarelis, Corey Langer, Sunil Singhal
Publikováno v:
Cancer Medicine, Vol 12, Iss 11, Pp 12208-12220 (2023)
Abstract Background Malignant pleural mesothelioma (MPM) is an aggressive cancer of the cells lining the pleural cavity with a low overall incidence. The National Cancer Database (NCDB) released in August 2022 updated data that reflect the newest tre
Externí odkaz:
https://doaj.org/article/ed26a58954f64344896a2d47c15390c7
Autor:
Zhen Lu, Jinyun Chen, Pengfei Yu, Matthew J. Atherton, Jun Gui, Vivek S. Tomar, Justin D. Middleton, Neil T. Sullivan, Sunil Singhal, Subin S. George, Ashley G. Woolfork, Aalim M. Weljie, Tsonwin Hai, Evgeniy B. Eruslanov, Serge Y. Fuchs
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Dendritic cells (DC) present tumour antigens to T cells but this process is defective in the tumour microenvironment. Here the authors find that downregulation of cholesterol 25-hydroxylase underlies defective cross presentation of tumour antigens.
Externí odkaz:
https://doaj.org/article/6f99c246674341cbadfcbbf971df3ad6
Autor:
Yingwen Hu, Danyang Chen, John V. Napoleon, Madduri Srinivasarao, Sunil Singhal, Cagri A. Savran, Philip S. Low
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Retrieval of circulating tumor cells (CTC) has proven valuable for assessing a patient's cancer burden, evaluating response to therapy, and analyzing which drug might treat a cancer best. Although most isolation methods retrieve CTCs based o
Externí odkaz:
https://doaj.org/article/94820e1958bd4c72822ccd227b145a1c
Autor:
Gregory T. Kennedy, Feredun S. Azari, Elizabeth Bernstein, Bilal Nadeem, Ashley Chang, Alix Segil, Sean Carlin, Neil T. Sullivan, Emmanuel Encarnado, Charuhas Desphande, Sumith Kularatne, Pravin Gagare, Mini Thomas, John C. Kucharczuk, Gaetan Christien, Francois Lacombe, Kaela Leonard, Philip S. Low, Aline Criton, Sunil Singhal
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Radiography identifies suspicious lung nodules that are not always easy to diagnose via biopsy. Here, the authors utilize a fluorescent dye that targets the folate receptor and show using needle based endomicroscopy that it can be used to identify ca
Externí odkaz:
https://doaj.org/article/2265f9b6134146e6a3286c12a2c662bd
Autor:
Burhan Uyanik, Anastasia R. Goloudina, Aamir Akbarali, Bogdan B. Grigorash, Alexey V. Petukhov, Sunil Singhal, Evgeniy Eruslanov, Jeanne Chaloyard, Lisa Lagorgette, Tarik Hadi, Ekaterina V. Baidyuk, Hiroyasu Sakai, Lino Tessarollo, Bernhard Ryffel, Sharlyn J. Mazur, Frederic Lirussi, Carmen Garrido, Ettore Appella, Oleg N. Demidov
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Wip1 is a negative regulator of the tumor suppressor p53 and is overexpressed in several human cancers. Here the authors show that inactivation of Wip1 in neutrophils promotes p53-dependent expression of co-stimulatory ligands and anti-tumor immune r
Externí odkaz:
https://doaj.org/article/ce056f276c7b4010b02dce368383e9c8