Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sunil K. Noothi"'
Autor:
Nathalia Araujo, James Sledziona, Sunil K. Noothi, Ravshan Burikhanov, Nikhil Hebbar, Saptadwipa Ganguly, Tripti Shrestha-Bhattarai, Beibei Zhu, Wendy S. Katz, Yi Zhang, Barry S. Taylor, Jinze Liu, Li Chen, Heidi L. Weiss, Daheng He, Chi Wang, Andrew J. Morris, Lisa A. Cassis, Mariana Nikolova-Karakashian, Prabhakar R. Nagareddy, Olle Melander, B. Mark Evers, Philip A. Kern, Vivek M. Rangnekar
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Prostate apoptosis response-4 (Par-4) is a tumor suppressor that induces apoptosis in cancer cells. However, the physiological function of Par-4 remains unknown. Here we show that conventional Par-4 knockout (Par-4-/-) mice and adipocyte-specific Par
Externí odkaz:
https://doaj.org/article/4120df1ef9614b949185e69e897e61c9
Autor:
Ravshan Burikhanov, Nikhil Hebbar, Sunil K. Noothi, Nidhi Shukla, James Sledziona, Nathália Araujo, Meghana Kudrimoti, Qing Jun Wang, David S. Watt, Danny R. Welch, Jodi Maranchie, Akihiro Harada, Vivek M. Rangnekar
Publikováno v:
Cell Reports, Vol 18, Iss 2, Pp 508-519 (2017)
Summary: The induction of tumor suppressor proteins capable of cancer cell apoptosis represents an attractive option for the re-purposing of existing drugs. We report that the anti-malarial drug, chloroquine (CQ), is a robust inducer of Par-4 secreti
Externí odkaz:
https://doaj.org/article/3ebeceb7b56a457eb08f0dec28efe808
Autor:
Bright Asare-Bediako, Sunil K. Noothi, Sergio Li Calzi, Baskaran Athmanathan, Cristiano P. Vieira, Yvonne Adu-Agyeiwaah, Mariana Dupont, Bryce A. Jones, Xiaoxin X. Wang, Dibyendu Chakraborty, Moshe Levi, Prabhakara R. Nagareddy, Maria B. Grant
Publikováno v:
Cells, Vol 9, Iss 2, p 464 (2020)
We sought to delineate the retinal features associated with the high-fat diet (HFD) mouse, a widely used model of obesity. C57BL/6 mice were fed either a high-fat (60% fat; HFD) or low-fat (10% fat; LFD) diet for up to 12 months. The effect of HFD on
Externí odkaz:
https://doaj.org/article/a183c0eaf9714996aea6d091fd86c677
Publikováno v:
Molecular and Cellular Biochemistry.
Atherosclerotic disease of the coronary and carotid arteries is the primary global cause of significant mortality and morbidity. The chronic occlusive diseases have changed the epidemiological landscape of health problems both in developed and the de
Autor:
James P. Collard, Mary K. McKenna, Sunil K. Noothi, Sara S. Alhakeem, Jacqueline R. Rivas, Vivek M. Rangnekar, Natarajan Muthusamy, Subbarao Bondada
Publikováno v:
Leukemia & Lymphoma. 63:1810-1822
The chronic lymphocytic leukemia (CLL) microenvironment has been receiving an increasing amount of attention, but there is currently limited data surrounding how the microenvironment affects initial development of CLL. We determined that the spleen i
Autor:
Ashish Dhyani, Hind Lal, Gerard Pernes, Chander Raman, Annas Al-Sharea, Ahmed Abdel-Latif, Rahul Annabathula, James E. Hudson, Gopalkrishna Sreejit, Beatriz Y Hanaoka, Sunil K. Noothi, Kate Schroder, Prabhakara R Nagareddy, Gregory A. Quaife-Ryan, Enzo R. Porrello, Maria B. Grant, Dragana Dragoljevic, Susan S. Smyth, Baskaran Athmanathan, Andrew J. Murphy
Publikováno v:
Circulation. 141:1080-1094
Background:Myocardial infarction (MI) triggers myelopoiesis, resulting in heightened production of neutrophils. However, the mechanisms that sustain their production and recruitment to the injured heart are unclear.Methods:Using a mouse model of the
Autor:
Baskaran Athmanathan, Prabhakara R Nagareddy, Jason L. Floyd, Yaqian Duan, Justin P. Wright, Dongni Feng, Mariana Dupont, Gavin Y. Oudit, Regina Lamendella, Eleni Beli, Maria B. Grant, Sunil K. Noothi, Gopalkrishna Sreejit, Amanda R. Jensen, Alexander G. Obukhov, Ram Prasad, Ana Leda F. Longhini, Troy A. Markel, Sergio Li Calzi
Publikováno v:
Circ Res
Rationale: There is incomplete knowledge of the impact of bone marrow cells on the gut microbiome and gut barrier function. Objective: We postulated that diabetes mellitus and systemic ACE2 (angiotensin-converting enzyme 2) deficiency would synergize
Autor:
Sunil K. Noothi, Mary K. McKenna, Sara S. Alhakeem, James P. Collard, J. T. Greene, Natarajan Muthusamy, Vivek M. Rangnekar, Subbarao Bondada
Publikováno v:
Tumor Suppressor Par-4 ISBN: 9783030805579
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::738d265e50e9cf8876353990c6cc46b4
https://doi.org/10.1007/978-3-030-80558-6_8
https://doi.org/10.1007/978-3-030-80558-6_8
Publikováno v:
Journal of Endocrinology. 238:R1-R11
Platelets play a critical role in both the initiation and progression of atherosclerosis, and even more so in the ensuing atherothrombotic complications. Low-dose aspirin remains the mainstay of antiplatelet therapy in high-risk patients by reducing
Autor:
Vivek M. Rangnekar, Roger A. Fleischman, Subbarao Bondada, Jacqueline R. Rivas, Sara S. Alhakeem, Sunil K. Noothi, Gerhard C. Hildebrandt, Natarajan Muthusamy, Mary K. McKenna, Karine Z. Oben
Publikováno v:
The Journal of Immunology. 200:4180-4189
Chronic lymphocytic leukemia (CLL) patients progressively develop an immunosuppressive state. CLL patients have more plasma IL-10, an anti-inflammatory cytokine, than healthy controls. In vitro human CLL cells produce IL-10 in response to BCR cross-l