Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Sunil G. Rattan"'
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 10, p 3207 (2018)
Following cardiac injury, fibroblasts are activated and are termed as myofibroblasts, and these cells are key players in extracellular matrix (ECM) remodeling and fibrosis, itself a primary contributor to heart failure. Nutraceuticals have been shown
Externí odkaz:
https://doaj.org/article/6ad4f8c57b0a46eab2e97482a0e76046
Publikováno v:
The Renin Angiotensin System in Cardiovascular Disease ISBN: 9783031149511
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e44fb2717172107b5dd161e048c4513
https://doi.org/10.1007/978-3-031-14952-8_13
https://doi.org/10.1007/978-3-031-14952-8_13
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2299
Two-dimensional cell culture is the primary method employed for proof-of-concept studies in most molecular biology labs. While immortalized cell lines are convenient and easy to maintain for extended periods in vitro, their inability to accurately re
Autor:
Ian M.C. Dixon, Thomas W. Meier, Robert R. Fandrich, Krista L. Filomeno, Todd A. Duhamel, Sunil G. Rattan, Elissavet Kardami, Navid Koleini, Sarah J. Foran, Simon C. Meier, Claire F. Meier, Natalie M. Landry
Publikováno v:
Basic Research in Cardiology
We have previously shown that overexpression of SKI, an endogenous TGF-β1 repressor, deactivates the pro-fibrotic myofibroblast phenotype in the heart. We now show that SKI also functions independently of SMAD/TGF-β signaling, by activating the Hip
Autor:
Ian M.C. Dixon, Besher Abual'anaz, Sunil G. Rattan, Krista L. Filomeno, Rebeca de Oliveira Camargo
Publikováno v:
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyREFERENCES. 29(4)
Heart disease with attendant cardiac fibrosis kills more patients in developed countries than any other disease, including cancer. We highlight the recent literature on factors that activate and also deactivate cardiac fibroblasts. Activation of card
Publikováno v:
Methods in Molecular Biology ISBN: 9781071613818
Two-dimensional cell culture is the primary method employed for proof-of-concept studies in most molecular biology labs. While immortalized cell lines are convenient and easy to maintain for extended periods in vitro, their inability to accurately re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da7e9a10d39ddcb51ce1b8bc314233a5
https://doi.org/10.1007/978-1-0716-1382-5_13
https://doi.org/10.1007/978-1-0716-1382-5_13
Autor:
Vernon W. Dolinsky, Richard Keijzer, Joseph W. Gordon, Nivedita Seshadri, Lucas Nguyen, Adrian R. West, Christine A. Doucette, Landon Falk, Jason Karch, Elizabeth S. Hensen, Ian M.C. Dixon, Sunil G. Rattan, Donald Chapman, Grant M. Hatch, Christof Rampitsch, Matthew D. Martens, Spencer B. Gibson, Bo Xiang, Arielys Mendoza, Ayesha D Saleem
Systemic hypoxia is a common element in most perinatal emergencies and is a known driver of Bnip3 expression in the neonatal heart. Bnip3 plays a prominent role in the evolution of necrotic cell death, disrupting ER calcium homeostasis and initiating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::100a0dfba49fb6924daa57b01e115033
https://doi.org/10.1101/2020.10.09.333666
https://doi.org/10.1101/2020.10.09.333666
Autor:
Wajihah Mughal, Matthew Martens, Donald Chapman, Yan Hai, Joseph W. Gordon, Vernon W. Dolinsky, Adrian R. West, Laura K. Cole, Kyle G. Cheung, William Diehl-Jones, Jared T. Field, Ian M.C. Dixon, Sunil G. Rattan, Richard Keijzer, Stephanie M. Kereliuk, Michael S. Parmacek, Jianhe Huang, Grant M. Hatch
Publikováno v:
Cell Death and Differentiation
Myocardin is a transcriptional co-activator required for cardiovascular development, but also promotes cardiomyocyte survival through an unclear molecular mechanism. Mitochondrial permeability transition is implicated in necrosis, while pore closure
Publikováno v:
Advances in experimental medicine and biology. 1132
Cardiac muscle (the myocardium) is a unique arrangement of atria and ventricles that are spatially and electrically separated by a fibrous border. The spirally-arranged myocytes in both left and right ventricles are tethered by the component molecule
Publikováno v:
The FASEB Journal. 33